Imaging of light emission from the expression of luciferases in living cells and organisms: a review

Firefly luciferase gene: structure and expression in mammalian cells.

de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,087

Extraction, Purification and Properties of Aequorin, a Bioluminescent Protein from the Luminous Hydromedusan, Aequorea

Shimomura, O., Johnson, F. H., & Saiga, Y. (1962) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030590302 · Cited by 2,384

Primary structure of the Aequorea victoria green-fluorescent protein

Prasher, D. C., Eckenrode, V. K., Ward, W. W., Prendergast, F. G., & Cormier, M. J. (1992) · Gene · doi:10.1016/0378-1119(92)90691-h · Cited by 2,177

The promoter of TL-DNA gene 5 controls the tissue-specific expression of chimaeric genes carried by a novel type of Agrobacterium binary vector

Koncz, C., & Schell, J. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00331014 · Cited by 2,032

Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming

Jouaville, L. S., Pinton, P., Bastianutto, C., Rutter, G. A., & Rizzuto, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13807 · Cited by 815

Transient and Stable Expression of the Firefly Luciferase Gene in Plant Cells and Transgenic Plants

Ow, D. W., Wood, K. V., DeLuca, M., de Wet, J. R., Helinski, D. R., & Howell, S. H. (1986) · Science · doi:10.1126/science.234.4778.856 · Cited by 725

Photonic detection of bacterial pathogens in living hosts

Contag, C. H., Contag, P. R., Mullins, J. I., Spilman, S. D., Stevenson, D. K., & Benaron, D. A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_18040593.x · Cited by 652

Circadian Clock Mutants in Arabidopsis Identified by Luciferase Imaging

Millar, A. J., Carré, I. A., Strayer, C. A., Chua, N.-H., & Kay, S. A. (1995) · Science · doi:10.1126/science.7855595 · Cited by 604

BIOLUMINESCENCE

Wilson, T., & Hastings, J. W. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.197 · Cited by 570

Genetic analysis of osmotic and cold stress signal transduction in Arabidopsis: interactions and convergence of abscisic acid-dependent and abscisic acid-independent pathways.

Ishitani, M., Xiong, L., Stevenson, B., & Zhu, J. K. (1997) · The Plant Cell · doi:10.1105/tpc.9.11.1935 · Cited by 531

Visualizing Gene Expression in Living Mammals Using a Bioluminescent Reporter

Contag, C. H., Spilman, S. D., Contag, P. R., Oshiro, M., Eames, B., Dennery, P., Stevenson, D. K., & Benaron, D. A. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03184.x · Cited by 526

Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli.

de Wet, J. R., Wood, K. V., Helinski, D. R., & DeLuca, M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7870 · Cited by 517

Circadian rhythms in prokaryotes: luciferase as a reporter of circadian gene expression in cyanobacteria.

Kondo, T., Strayer, C. A., Kulkarni, R. D., Taylor, W., Ishiura, M., Golden, S. S., & Johnson, C. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5672 · Cited by 495

Rapid and Quantitative Assessment of Cancer Treatment Response Using In Vivo Bioluminescence Imaging

Rehemtulla, A., Stegman, L. D., Cardozo, S. J., Gupta, S., Hall, D. E., Contag, C. H., & Ross, B. D. (2000) · Neoplasia · doi:10.1038/sj.neo.7900121 · Cited by 460

A novel circadian phenotype based on firefly luciferase expression in transgenic plants.

Millar, A. J., Short, S. R., Chua, N. H., & Kay, S. A. (1992) · The Plant Cell · doi:10.1105/tpc.4.9.1075 · Cited by 390

Circadian orchestration of gene expression in cyanobacteria.

Liu, Y., Tsinoremas, N. F., Johnson, C. H., Lebedeva, N. V., Golden, S. S., Ishiura, M., & Kondo, T. (1995) · Genes & Development · doi:10.1101/gad.9.12.1469 · Cited by 372

BACTERIAL BIOLUMINESCENCE

Hastings, J. W., & Nealson, K. H. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.003001 · Cited by 368

Isolation and expression of a cDNA encoding Renilla reniformis luciferase.

Lorenz, W. W., McCann, R. O., Longiaru, M., & Cormier, M. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4438 · Cited by 366

Use of Reporter Genes for Optical Measurements of Neoplastic Disease In Vivo

Contag, C. H., Jenkins, D., Contag, P. R., & Negrin, R. S. (2000) · Neoplasia · doi:10.1038/sj.neo.7900079 · Cited by 363

Monitoring Bioluminescent Staphylococcus aureus Infections in Living Mice Using a Novel luxABCDE Construct

Francis, K. P., Joh, D., Bellinger-Kawahara, C., Hawkinson, M. J., Purchio, T. F., & Contag, P. R. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3594-3600.2000 · Cited by 339

Cloning and sequence analysis of cDNA for the luminescent protein aequorin.

Inouye, S., Noguchi, M., Sakaki, Y., Takagi, Y., Miyata, T., Iwanaga, S., Miyata, T., & Tsuji, F. I. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3154 · Cited by 327

Glucose Generates Sub-plasma Membrane ATP Microdomains in Single Islet β-Cells

Kennedy, H. J., Pouli, A. E., Ainscow, E. K., Jouaville, L. S., Rizzuto, R., & Rutter, G. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13281 · Cited by 305

HOS1, a Genetic Locus Involved in Cold-Responsive Gene Expression in Arabidopsis

Ishitani, M., Xiong, L., Lee, H., Stevenson, B., & Zhu, J.-K. (1998) · The Plant Cell · doi:10.1105/tpc.10.7.1151 · Cited by 300

Peroxisomal protein import is conserved between yeast, plants, insects and mammals.

Gould, S. J., Keller, G. A., Schneider, M., Howell, S. H., Garrard, L. J., Goodman, J. M., Distel, B., Tabak, H., & Subramani, S. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08083.x · Cited by 295

Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression.

Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H., Moossa, A. R., & Hoffman, R. M. (1997) · PubMed · Cited by 284

Biological diversity, chemical mechanisms, and the evolutionary origins of bioluminescent systems

Hastings, J. W. (1983) · Journal of Molecular Evolution · doi:10.1007/bf02101634 · Cited by 284

Noninvasive Optical Imaging of Firefly Luciferase Reporter Gene Expression in Skeletal Muscles of Living Mice

Wu, J. C., Sundaresan, G., Iyer, M., & Gambhir, S. S. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0460 · Cited by 273

Visualizing Pneumococcal Infections in the Lungs of Live Mice Using Bioluminescent Streptococcus pneumoniae Transformed with a Novel Gram-Positive lux Transposon

Francis, K. P., Yu, J., Bellinger-Kawahara, C., Joh, D., Hawkinson, M. J., Xiao, G., Purchio, T. F., Caparon, M. G., Lipsitch, M., & Contag, P. R. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.3350-3358.2001 · Cited by 249

Oxidative burst and cognate redox signalling reported by luciferase imaging: identification of a signal network that functions independently of ethylene, SA and Me‐JA but is dependent on MAPKK activity

Grant, J. J., Yun, B., & Loake, G. J. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00902.x · Cited by 242

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

Rutter, G. A., Burnett, P., Rizzuto, R., Brini, M., Murgia, M., Pozzan, T., Tavaré, J. M., & Denton, R. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5489 · Cited by 241

Polyphasic classification of the genus Photorhabdus and proposal of new taxa: P. luminescens subsp. luminescens subsp. nov., P. luminescens subsp. akhurstii subsp. nov., P. luminescens subsp. laumondii subsp. nov., P. temperata sp. nov., P. temperata subsp. temperata subsp. nov. and P. asymbiotica sp. nov.

Fischer-Le Saux, M., Viallard, V., Brunel, B., Normand, P., & Boemare, N. E. (1999) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/00207713-49-4-1645 · Cited by 236

Purification and properties of Renilla reniformis luciferase

Matthews, J. C., Hori, K., & Cormier, M. J. (1977) · Biochemistry · doi:10.1021/bi00620a014 · Cited by 229

Systematic distribution of bioluminescence in living organisms

Herring, P. J. (1987) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/bio.1170010303 · Cited by 228

Cloning and expression of the cDNA coding for aequorin, a bioluminescent calcium-binding protein

Prasher, D., McCann, R. O., & Cormier, M. J. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90321-3 · Cited by 227

Visualizing mRNA expression in plant protoplasts: factors influencing efficient mRNA uptake and translation.

Gallie, D. R., Lucas, W. J., & Walbot, V (1989) · The Plant Cell · doi:10.1105/tpc.1.3.301 · Cited by 221

Construction of luciferase reporter bacteriophage A511::luxAB for rapid and sensitive detection of viable Listeria cells

Loessner, M. J., Rees, C. E., Stewart, G. S., & Scherer, S. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.4.1133-1140.1996 · Cited by 211

A Targetable, Injectable Adenoviral Vector for Selective Gene Delivery to Pulmonary Endothelium in Vivo

Reynolds, P. N., Zinn, K. R., Gavrilyuk, V. D., Balyasnikova, I. V., Rogers, B. E., Buchsbaum, D. J., Wang, M. H., Miletich, D. J., Grizzle, W. E., Douglas, J. T., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0205 · Cited by 203

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

da Silva Xavier, G., Leclerc, I., Salt, I. P., Doiron, B., Hardie, D. G., Kahn, A., & Rutter, G. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4023 · Cited by 203

Interaction of Osmotic Stress, Temperature, and Abscisic Acid in the Regulation of Gene Expression in Arabidopsis

Xiong, L., Ishitani, M., & Zhu, J.-K. (1999) · Plant Physiology · doi:10.1104/pp.119.1.205 · Cited by 197

Simultaneous Monitoring of Cell Number and Metabolic Activity of Specific Bacterial Populations with a Dual gfp-luxAB Marker System

Unge, A., Tombolini, R., Mølbak, L., & Jansson, J. K. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.2.813-821.1999 · Cited by 191

Firefly luciferase is targeted to peroxisomes in mammalian cells.

Keller, G. A., Gould, S., Deluca, M., & Subramani, S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3264 · Cited by 188

agr Expression Precedes Escape of Internalized Staphylococcus aureus from the Host Endosome

Qazi, S. N. A., Counil, E., Morrissey, J., Rees, C. E. D., Cockayne, A., Winzer, K., Chan, W. C., Williams, P., & Hill, P. J. (2001) · Infection and Immunity · doi:10.1128/iai.69.11.7074-7082.2001 · Cited by 186

Adoptive Immunotherapy of Experimental Autoimmune Encephalomyelitis Via T Cell Delivery of the IL-12 p40 Subunit

Costa, G. L., Sandora, M. R., Nakajima, A., Nguyen, E. V., Taylor-Edwards, C., Slavin, A. J., Contag, C. H., Fathman, C. G., & Benson, J. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2379 · Cited by 171

Nucleotide sequence of the luxA gene of Vibrio harveyi and the complete amino acid sequence of the alpha subunit of bacterial luciferase.

Cohn, D. H., Mileham, A. J., Simon, M. I., Nealson, K. H., Rausch, S. K., Bonam, D., & Baldwin, T. O. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88948-7 · Cited by 168

An Exclusive Contract: Specificity in the Vibrio fischeri-Euprymna scolopes Partnership

Visick, K. L., & McFall-Ngai, M. J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.7.1779-1787.2000 · Cited by 166

In Utero Delivery of Adeno-Associated Viral Vectors: Intraperitoneal Gene Transfer Produces Long-Term Expression

Lipshutz, G. S., Gruber, C. A., Cao, Y.-A., Hardy, J., Contag, C. H., & Gaensler, K. M. L. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0267 · Cited by 158

L5 luciferase reporter mycobacteriophages: a sensitive tool for the detection and assay of live mycobacteria

Sarkis, G. J., Jacobs, W. R., & Hatfull, G. F. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02281.x · Cited by 158

The eyes of deep-sea fish I: Lens pigmentation, tapeta and visual pigments

Douglas, R. H., Partridge, J. C., & Marshall, N. J. (1998) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(98)00002-0 · Cited by 157

Cloning of the luciferase structural genes from Vibrio harveyi and expression of bioluminescence in Escherichia coli

Baldwin, T. O., Sexton, T. B., Bunch, T. A., Holzman, T. F., Rausch, S. K., Shamansky, L. M., Treat, M. L., & Ziegler, M. M. (1984) · Biochemistry · doi:10.1021/bi00311a014 · Cited by 156

Imaging Transgene Expression in Live Animals

Honigman, A., Zeira, E., Ohana, P., Abramovitz, R., Tavor, E., Bar, I., Zilberman, Y., Rabinovsky, R., Gazit, D., Joseph, A., et al. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0437 · Cited by 154

Measuring Gene Expression with Light

Engebrecht, J., Simon, M. I., & Silverman, M. R. (1985) · Science · doi:10.1126/science.2983423 · Cited by 153

Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA

Thierry, A. R., Rabinovich, P., Peng, B., Mahan, L. C., Bryant, J., & Gallo, R. C. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300350 · Cited by 151

Validation of a Noninvasive, Real-Time Imaging Technology Using Bioluminescent Escherichia coli in the Neutropenic Mouse Thigh Model of Infection

Rocchetta, H. L., Boylan, C. J., Foley, J. W., Iversen, P. W., LeTourneau, D. L., McMillian, C. L., Contag, P. R., Jenkins, D. E., & Parr, T. R. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.129-137.2001 · Cited by 148

TheVibrio fischeri-Euprymna scolopesLight Organ Association: Current Ecological Paradigms

Ruby, E. G., & Lee, K. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.3.805-812.1998 · Cited by 146

An energy transfer protein in coelenterate bioluminescence. Characterization of the Renilla green-fluorescent protein.

Ward, W. W., & Cormier, M. J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37873-0 · Cited by 144

Firefly Luciferase

DeLuca, M. A. (1976) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122891.ch2 · Cited by 140

Development of a Destabilized Firefly Luciferase Enzyme for Measurement of Gene Expression

Leclerc, G. M., Boockfor, F. R., Faught, W. J., & Frawley, L. S. (2000) · BioTechniques · doi:10.2144/00293rr02 · Cited by 138

Hydrophobic nature of the active site of firefly luciferase

DeLuca, M. (1969) · Biochemistry · doi:10.1021/bi00829a023 · Cited by 134

Secretional luciferase of the luminous shrimpOplophorus gracilirostris: cDNA cloning of a novel imidazopyrazinone luciferase

Inouye, S., Watanabe, K., Nakamura, H., & Shimomura, O. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01963-3 · Cited by 132

Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins.

Gould, S. J., Krisans, S. K., Keller, G. A., & Subramani, S. E. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.1.27 · Cited by 132

Mutationally altered bacterial luciferase. Implications for subunit functions

Cline, T. W., & Hastings, J. W. (1972) · Biochemistry · doi:10.1021/bi00768a008 · Cited by 127

Construction of promoter probe vectors for Synechocystis sp. PCC 6803 using the light-emitting reporter systems Gfp and LuxAB

Kunert, A., Hagemann, M., & Erdmann, N. (2000) · Journal of Microbiological Methods · doi:10.1016/s0167-7012(00)00162-7 · Cited by 113

The Use ofRenillaLuciferase,OplophorusLuciferase, and Apoaequorin as Bioluminescent Reporter Protein in the Presence of Coelenterazine Analogues as Substrate

Inouye, S., & Shimomura, O. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6452 · Cited by 109

Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth muscle‐derived cell line

James, T. W., Wagner, R. J., White, L. A., Zwolak, R. M., & Brinckerhoff, C. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041570227 · Cited by 99

Dragon fish see using chlorophyll

Douglas, R. H., Partridge, J. C., Dulai, K. S., Hunt, D. M., Mullineaux, C. W., Tauber, A. Y., & Hynninen, P. H. (1998) · Nature · doi:10.1038/30871 · Cited by 94

Characterization of position‐induced spatial and temporal regulation of transgene promoter activity in plants

van Leeuwen, W., Ruttink, T., Borst-Vrenssen, A. W. M., van der Plas, L. H. W., & van der Krol, A. R. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.358.949 · Cited by 94

Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging

Mueller-Klieser, W., & Walenta, S. (1993) · The Histochemical Journal · doi:10.1007/bf00157805 · Cited by 93

Mitochondrial priming modifies Ca2+ oscillations and insulin secretion in pancreatic islets

Ainscow, E., & Rutter, G. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530175 · Cited by 90

Far Red Bioluminescence from Two Deep-Sea Fishes

Widder, E. A., Latz, M. I., Herring, P. J., et al. (1984) · Science · doi:10.1126/science.225.4661.512 · Cited by 89

Bacterial luciferase alpha beta fusion protein is fully active as a monomer and highly sensitive in vivo to elevated temperature.

Escher, A., O’Kane, D. J., Lee, J., et al. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6528 · Cited by 89

Metastatic patterns of lung cancer visualized live and in process by green fluorescence protein expression

Chishima, T., Miyagi, Y., Wang, X., Baranov, E. A., Tan, Y., Shimada, H., Moossa, A. R., & Hoffman, R. M. (1997) · Clinical & Experimental Metastasis · doi:10.1023/a:1018431128179 · Cited by 83

Real-time analysis of the transcriptional regulation of hiv and hcmv promoters in single mammalian cells

White, M., Masuko, M., Amet, L., et al. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.2.441 · Cited by 82

Regulation of Gene Expression by Glucose in Pancreatic β-Cells (MIN6) via Insulin Secretion and Activation of Phosphatidylinositol 3′-Kinase

Xavier, G. D. S., Váradi, A., Ainscow, E., & Rutter, G. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006597200 · Cited by 82

Far-red sensitivity of dragon fish

Partridge, J. C., & Douglas, R. H. (1995) · Nature · doi:10.1038/375021a0 · Cited by 79

Dynamic Changes in Prolactin Promoter Activation in Individual Living Lactotrophic Cells

Takasuka, N., White, M., Wood, C. D., et al. (1998) · Endocrinology · doi:10.1210/endo.139.3.5826 · Cited by 79

Sequence comparisons of complementary DNAs encoding aequorin isotypes

Prasher, D. C., McCann, R. O., Longiaru, M., & Cormier, M. J. (1987) · Biochemistry · doi:10.1021/bi00379a019 · Cited by 77

MGSA/GRO-mediated melanocyte transformation involves induction of Ras expression

Wang, D., Yang, W., Du, J., Devalaraja, M. N., Liang, P., Matsumoto, K., Tsubakimoto, K., Endo, T., & Richmond, A. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203820 · Cited by 76

Visualization of the metastatic process by green fluorescent protein expression.

Chishima, T., Miyagi, Y., Wang, X., Tan, Y., Shimada, H., Moossa, A. R., & Hoffman, R. M. (1997) · PubMed · Cited by 72

Membrane-permeable luciferin esters for assay of firefly luciferase in live intact cells

Craig, F. F., Simmonds, A. C., Watmore, D., McCapra, F., & White, M. (1991) · Biochemical Journal · doi:10.1042/bj2760637 · Cited by 70

Long‐term, noninvasive imaging of regulated gene expression in living mice

Hasan, M. T., Schönig, K., Berger, S. M., Graewe, W., & Bujard, H. (2001) · genesis · doi:10.1002/gene.1014 · Cited by 70

Involvement of MAP kinase in insulin signalling revealed by non-invasive imaging of luciferase gene expression in single living cells

Rutter, G. A., White, M., & Tavaré, J. M. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00179-5 · Cited by 69

Enhanced retinal longwave sensitivity using a chlorophyll-derived photosensitiser in Malacosteus niger, a deep-sea dragon fish with far red bioluminescence

Douglas, R. H., Partridge, J. C., Dulai, K. S., Hunt, D. M., Mullineaux, C. W., & Hynninen, P. H. (1999) · Vision Research · doi:10.1016/s0042-6989(98)00332-0 · Cited by 68

Renilla reniformis bioluminescence: luciferase-catalyzed production of nonradiating excited states from luciferin analogs and elucidation of the excited state species involved in energy transfer to Renilla green fluorescent protein

Hart, R. C., Matthews, J. C., Hori, K., & Cormier, M. J. (1979) · Biochemistry · doi:10.1021/bi00578a011 · Cited by 66

Renilla luciferase as a vital reporter for chloroplast gene expression in Chlamydomonas

Minko, I. G., Holloway, S. P., Nikaido, S. S., Carter, M., ODOM, O. W., Johnson, C. H., & Herrin, D. L. (1999) · Molecular and General Genetics MGG · doi:10.1007/s004380051101 · Cited by 64

Regional Quantitative Determination of Lactate in Brain Sections. A Bioluminescent Approach

Paschen, W. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.90 · Cited by 61

Genetic Immunization with Lung-Targeting Macroaggregated Polyethyleneimine-Albumin Conjugates Elicits Combined Systemic and Mucosal Immune Responses

Orson, F. M., Kinsey, B. M., Hua, P., Bhogal, B. S., Densmore, C. L., & Barry, M. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6313 · Cited by 56

Dynamic monitoring and quantification of gene expression in single, living cells: a molecular basis for secretory cell heterogeneity

Castano, J. P., Kineman, R. D., & Frawley, L. S. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.5.8732690 · Cited by 51

Rare germinal unequal crossing-over leading to recombinant gene formation and gene duplication in Arabidopsis thaliana

Jelesko, J. G., Harper, R. A., Furuya, M., & Gruissem, W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10302 · Cited by 50

Mechanism of Calcium Induction of Renilla Bioluminescence. Involvement of a Calcium-Triggered Luciferin Binding Protein

Anderson, J. M., Charbonneau, H., & Cormier, M. J. (1974) · Biochemistry · doi:10.1021/bi00703a602 · Cited by 48

Effect of nickel‐based dental casting alloys on fibroblast metabolism and ultrastructural organization

Bumgardner, J. D., Doeller, J. E., & Lucas, L. C. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820290508 · Cited by 47

Green tea extract and its polyphenols markedly inhibit luminol-dependent chemiluminescence activated by peroxynitrite or SIN-1

Dyke, K. V., McConnell, P., & Marquardt, L. (2000) · Luminescence · doi:10.1002/(sici)1522-7243(200001/02)15:1<45::aid-bio553>3.0.co;2-e · Cited by 44

A study of protein-protein interactions in living cells using luminescence resonance energy transfer (LRET) from Renilla luciferase to Aequorea GFP

Wang, Y., Wang, G., O’Kane, D. J., & Szalay, A. A. (2001) · Molecular and General Genetics MGG · doi:10.1007/s004380000322 · Cited by 37

Extraction of Renilla-type luciferin from the calcium-activated photoproteins aequorin, mnemiopsin, and berovin.

Ward, W. W., & Cormier, M. J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.7.2530 · Cited by 33

Bioluminescence for Biological Sensing in Living Mammals

Zhang, W., Contag, P. R., Madan, A., Stevenson, D. K., & Contag, C. H. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4717-4_89 · Cited by 30

Ligand substitution of receptor targeted DNA complexes affects gene transfer into hepatoma cells

Ziady, A. G., Ferkol, T., Gerken, T. A., Dawson, D., Dh, P., & Davis, P. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300777 · Cited by 30

Commercially Available Luminometers and Imaging Devices for Low-Light Level Measurements and Kits and Reagents Utilizing Bioluminescence or Chemiluminescence: Survey Update 4

Stanley, P. E. (1996) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/(sici)1099-1271(199607)11:4/5<175::aid-bio421>3.0.co;2-f · Cited by 30

In vitro rat myocyte cardiotoxicity model for antitumor antibiotics using adenosine triphosphate/protein ratios.

Dorr, R. T., Bozak, K. A., Shipp, N. G., et al. (1988) · PubMed · Cited by 29

Metabolic imaging in tumours by means of bioluminescence

Tamulevicius, P., & Streffer, C. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.472 · Cited by 28

Excited-state proton transfer and the mechanism of action of firefly luciferase

Bowie, L. J., Irwin, R., Loken, M. R., et al. (1973) · Biochemistry · doi:10.1021/bi00734a002 · Cited by 27

Imaging bioluminescent indicators shows Ca2+ and ATP permeability thresholds in live cells attacked by complement

SALA‐NEWBY, Taylor, K. M., BADMINTON, Rembold, C. M., & Campbell, A. K. (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00004.x · Cited by 25

Commercially available luminometers and imaging devices for low-light level measurements and kits and reagents utilizing bioluminescence or chemiluminescence: Survey update 5

Stanley, P. E. (1997) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/(sici)1099-1271(199703/04)12:2<61::aid-bio452>3.0.co;2-7 · Cited by 25

Use of lux genes in applied biochemistry

Hill, P. J., & Stewart, G. S. A. B. (1994) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/bio.1170090315 · Cited by 21

Imaging of Energy Metabolites (ATP, Glucose and Lactate) in Tissue Sections: A Bioluminescent Technique

Paschen, W. (1990) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(11)80071-9 · Cited by 14

In vivo gene electroporation confers nutritionally-regulated foreign gene expression in the liver.

Muramatsu, T., Ito, N., Tamaoki, N., et al. (2001) · International Journal of Molecular Medicine · doi:10.3892/ijmm.7.1.61 · Cited by 12

Identification of plant genesin vivo by tagging with T-DNA border-linked luciferase genes followed by inverse polymerase chain reaction amplification

Jiang, C., Langridge, W. H. R., & Szalay, A. A. (1992) · Plant Molecular Biology Reporter · doi:10.1007/bf02668911 · Cited by 11

Mitochondria and calcium homeostasis: a tale of three luminescent proteins

Magalhães, P. J., & Rizzuto, R. (2001) · Luminescence · doi:10.1002/bio.614 · Cited by 10

Strategies in In Vivo Molecular Imaging

Contag, C. H., Fraser, S. E., & Weissleder, R. (2000) · NeoReviews · doi:10.1542/neo.1-12-e225 · Cited by 8

Applications of In Vivo Molecular Imaging in Biology and Medicine

Contag, C. H., Weissleder, R., Bachmann, M. H., & Fraser, S. E. (2000) · NeoReviews · doi:10.1542/neo.1-12-e233 · Cited by 5

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Campbell, A. K., Sala‐Newby, G. B., Aston, P. J., Kalsheker, N. A., Kishi, Y., & Shimomura, O. (1990) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/bio.1170050209 · Cited by 4

Detection of bioluminescence from individual bacterial cells: a comparison of two different low‐light imaging systems

Sternberg, C., Eberl, L., Poulsen, L. K., et al. (1997) · Journal of Bioluminescence and Chemiluminescence · doi:10.1002/(sici)1099-1271(199701/02)12:1<7::aid-bio427>3.0.co;2-3 · Cited by 3

Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression

Welsh, D. K., Yoo, S.-H., Liu, A. C., Takahashi, J. S., & Kay, S. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.057 · Cited by 726

Applications of bioluminescence in biotechnology and beyond

Syed, A. J., & Anderson, J. C. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01492c · Cited by 341

In vivo molecular and genomic imaging: new challenges for imaging physics

Cherry, S. R. (2004) · Physics in Medicine and Biology · doi:10.1088/0031-9155/49/3/r01 · Cited by 334

Bioluminescence imaging in living organisms

Welsh, D. K., & Kay, S. A. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.12.006 · Cited by 185

Influence of mesenchymal stem cells on metastasis development in mice in vivo

Meleshina, A. V., Cherkasova, E. I., Shirmanova, M. V., Klementieva, N. V., Kiseleva, E. V., Snopova, L. В., Prodanets, N. N., & Zagaynova, E. V. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0003-7 · Cited by 45