Biochemical investigation and gene analysis of equol: A plant and soy‐derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications

More than 100,000 women have used topically-applied equol with great success.

“more than 100,000 women have used topically-applied equol with great success [2,78,84,85].”

Equol stimulates antioxidant enzymes SOD2 and TXNRD1 in human skin.

“From gene array studies, equol has been shown to stimulate the following antioxidant enzymes in human skin, such as SOD 2 and thioredoxin reductase 1 (TXNRD 1) [84,85].”

Topical applications of equol have demonstrated improved human dermal parameters in in vitro, ex vivo, and in vivo studies.

“several reports using topical applications of equol have demonstrated improved human dermal parameters”

Topical equol treatment in human skin via gene array studies demonstrated that interleukin levels (IL-1, IL-6, IL-8) and cyclo-oxygenase 1 (COX-1) were significantly inhibited.

“topical equol treatment in human skin via gene array studies have demonstrated that interleukin (IL) levels were significantly inhibited (such as IL-I, IL-6, IL-8 as well as cyclo-oxygenase 1 (COX-1)) [84,85].”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol increases the gene and protein expression of collagen type I.

“Equol increases the gene and protein expression of collagen type I, elastin, and tissue inhibitor of matrix metalloproteinase 1 (TIMP 1).”

Equol increases tissue inhibitor of matrix metalloproteinase 1 (TIMP1) by 5.4-fold.

“along with increasing tissue inhibitor of matrix metalloproteinase 1 (TIMP 1) by 5.4-fold”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol increases the gene and protein expression of elastin.

“Equol increases the gene and protein expression of collagen type I, elastin, and tissue inhibitor of matrix metalloproteinase 1 (TIMP 1).”

Tumor necrosis factor receptor levels were significantly inhibited by equol when compared to controls.

“tumor necrosis factor receptor levels were significantly inhibited by equol when compared to controls [84,85].”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol increases the gene and protein expression of tissue inhibitor of matrix metalloproteinase 1 (TIMP 1).

“Equol increases the gene and protein expression of collagen type I, elastin, and tissue inhibitor of matrix metalloproteinase 1 (TIMP 1).”

Equol significantly increases gene and protein expression of collagen and elastin by approximately 2-fold.

“From gene array and human fibroblast cell culture experiments equol has been shown to significantly increase the gene and protein expression of collagen and elastin by approximately 2-fold”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol inhibits the gene and protein expression of matrix metalloproteinase 9 (MMP 9).

“Equol inhibits the gene and protein expression of elastase and the matrix metalloproteinases (MMP 1, MMP 3, and MMP 9).”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol inhibits the gene and protein expression of matrix metalloproteinase 3 (MMP 3).

“Equol inhibits the gene and protein expression of elastase and the matrix metalloproteinases (MMP 1, MMP 3, and MMP 9).”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol inhibits the gene and protein expression of elastase.

“Equol inhibits the gene and protein expression of elastase and the matrix metalloproteinases (MMP 1, MMP 3, and MMP 9).”

In in vitro cell culture, organotypic cell cultures, and gene array studies, equol inhibits the gene and protein expression of matrix metalloproteinase 1 (MMP 1).

“Equol inhibits the gene and protein expression of elastase and the matrix metalloproteinases (MMP 1, MMP 3, and MMP 9).”