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Bioactive peptides derived from food proteins preventing lifestyle‐related diseases
Abstract
Many kinds of bioactive peptides which might prevent lifestyle‐related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I‐converting enzyme (ACE) having anti‐hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8‐fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2–7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.
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Cited by
The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease
Erdmann, K., Cheung, B. W. Y., & Schröder, H. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.11.010 · Cited by 717
Bioactive peptides and proteins from foods: indication for health effects.
Möller, N. P., Scholz-Ahrens, K. E., Roos, N., & Schrezenmeir, J. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0710-2 · Cited by 595
Wu, J., Aluko, R. E., & Nakai, S. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051263l · Cited by 561
Marine Bioactive Compounds and Their Health Benefits: A Review
Hamed, I., Özogul, F., Özogul, Y., & Regenstein, J. M. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12136 · Cited by 444
Huang, W.-Y., Davidge, S. T., & Wu, J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.550071 · Cited by 157
Metadata
- Authors
- Yoshikawa, M., Fujita, H., Matoba, N., Takenaka, Y., Yamamoto, T., Yamauchi, R., Tsuruki, H., & Takahata, K.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2000-01
- Volume
- 12
- Issue
- 1-4
- Pages
- 143-146
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W2003555315
- Cited by
- 249
- References
- 0
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yoshikawa, M., Fujita, H., Matoba, N., Takenaka, Y., Yamamoto, T., Yamauchi, R., Tsuruki, H., & Takahata, K. (2000). Bioactive peptides derived from food proteins preventing lifestyle‐related diseases. BioFactors. https://doi.org/10.1002/biof.5520120122
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