Cited by 157Protein Hydrolysis and Bioactive PeptidesSodium Intake and HealthBlood Pressure and Hypertension Studies

Bioactive Natural Constituents from Food Sources—Potential Use in Hypertension Prevention and Treatment

Huang, Wu-Yang, Davidge, Sandra T., Wu, Jianping·2013·Critical Reviews in Food Science and Nutrition

Abstract

Prevention and management of hypertension are the major public health challenges worldwide. Uncontrolled high blood pressure may lead to a shortened life expectancy and a higher morbidity due to a high risk of cardiovascular complications such as coronary heart disease (which leads to heart attack) and stroke, congestive heart failure, heart rhythm irregularities, and kidney failure etc. In recent years, it has been recognized that many dietary constituents may contribute to human cardiovascular health. There has been an increased focus on identifying these natural components of foods, describing their physiological activities and mechanisms of actions. Grain, vegetables, fruits, milk, cheese, meat, chicken, egg, fish, soybean, tea, wine, mushrooms, and lactic acid bacteria are various food sources with potential antihypertensive effects. Their main bioactive constituents include angiotensin I-converting enzyme (ACE) inhibitory peptides, vitamins C and E, flavonoids, flavanols, cathecins, anthocyanins, phenolic acids, polyphenols, tannins, resveratrol, polysaccharides, fiber, saponin, sterols, as well as K, Ca, and P. They may reduce blood pressure by different mechanisms, such as ACE inhibition effect, antioxidant, vasodilatory, opiate-like, Ca(2+) channel blocking, and chymase inhibitory activities. These functional foods may provide new therapeutic applications for hypertension prevention and treatment, and contribute to a healthy cardiovascular population. The present review summarizes the antihypertensive food sources and their bioactive constituents, as well as physiological mechanisms of dietary products, especially focusing on ACE inhibitory activity.

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Crossref · 10.1080/10408398.2010.550071

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  • Functional foods attempt to improve health by incorporating bioactive compounds that may alter lipid, vascular, and other metabolic pathways, microbiome composition and function, and digestive and inflammatory systems.

    “Similar to dietary supplements, functional foods attempt to improve health by incorporating bioactive compounds that may alter lipid, vascular, and other metabolic pathways, microbiome composition and function, and digestive and inflammatory systems.114-121”

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Authors
Huang, W.-Y., Davidge, S. T., & Wu, J.
Affiliations
University of Alberta (CA)
Venue
Critical Reviews in Food Science and Nutrition
Published
2013-01
Volume
53
Issue
6
Pages
615-630
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W2118713736
Cited by
157
References
189
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 17 · 2017: 25 · 2016: 17 · 2015: 18 · 2014: 18 · 2013: 1
FWCI
8.07
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Government of Jiangsu Province
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
hypertension, angiotensin I-converting enzyme inhibitory peptides, functional foods, flavonoids, polyphenols, resveratrol, antioxidant defense, cardiovascular health, dietary minerals
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Animals, Antihypertensive Agents, Antioxidants, Blood Pressure, Edible Grain, Dairy Products, Eggs, Fruit, Humans, Hypertension, Fabaceae, Meat, Nuts, Tea, Vegetables

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