Soft sensors in bioprocessing: A status report and recommendations

Luttmann, Reiner, Bracewell, Daniel G., Cornelissen, Gesine, Gernaey, Krist V., Glassey, Jarka, Hass, Volker C., Kaiser, Christian, Preusse, Christian, Striedner, Gerald, Mandenius, Carl‐Fredrik·2012·Biotechnology Journal

DOI 10.1002/biot.201100506

Cited by (238)

Items 101–200 of 238

Accelerating vaccine manufacturing development through model-based approaches: current advances and future opportunities
Elham Ramin, Antonio Gaetano Cardillo, Reinhard Liebers, Johannes Schmölder, Eric von Lieres, Wim Van Molle, Bastian Niebel, Laurent C. Natalis, Irina Meln, Mónica Perea-Vélez et al. · 2023 · Current Opinion in Chemical Engineering
A soft sensor based on online biomass measurements for the glucose estimation and control of fed-batch cultures of Bacillus thuringiensis
Abdi Escalante-Sánchez, Josefina Barrera-Cortés, Hector Mario Poggi-Varaldo, Teresa Ponce‐Noyola, Ieroham Solomon Baruch · 2018 · Bioprocess and Biosystems Engineering
Soft sensor for an orifice flowmeter in presence of disturbances
Sravani Vemulapalli, Santhosh Krishnan Venkata · 2022 · Flow Measurement and Instrumentation
Implementation of quality by design toward processing of food products
Anurag Singh Rathore, Gautam Kapoor · 2017 · Preparative Biochemistry & Biotechnology
The Kalman Filter for the Supervision of Cultivation Processes
Yousefi-Darani, Abdolrahim, Paquet-Durand, Olivier, Hitzmann, Bernd · 2020 · Advances in Biochemical Engineering/Biotechnology
Moisture soft sensor for agitated pan dryers using a hybrid modeling approach
Zilong Wang, Reza Kamyar, Hamidreza Mehdizadeh, Pushkar Yashvant Pendse · 2020 · International Journal of Pharmaceutics
Off-Gas-Based Soft Sensor for Real-Time Monitoring of Biomass and Metabolism in Chinese Hamster Ovary Cell Continuous Processes in Single-Use Bioreactors
Tobias Wallocha, Oliver Popp · 2021 · Processes
Perfusion Cell Culture Processes for Biopharmaceuticals
Moritz Wolf, Jean‐Marc Bielser, Massimo Morbidelli · 2020 · Cambridge University Press eBooks
Industrial steam systems: Strategic framework with proxy measurements to evaluate the total cost of steam
Dominik Seiler, Dan Donovan, Garret E. O’Donnell · 2019 · Journal of Cleaner Production
Data-Driven Soft Sensor Model Based on Deep Learning for Quality Prediction of Industrial Processes
Xianglin Zhu, Khalil Ur Rehman, Bo Wang, Muhammad Shahzad, Ahmad Hassan · 2021 · SN Computer Science
Deployment of metabolic heat rate based soft sensor for estimation and control of specific growth rate in glycoengineered Pichia pastoris for human interferon alpha 2b production
Satya Sai Pavan, Sivakumar Rathinavelu, Naresh Mohan, Senthilkumar Sivaprakasam · 2022 · Journal of Biotechnology
Microbial technologies for biotherapeutics production: Key tools for advanced biopharmaceutical process development and control.
Dénes Zalai, J. Kopp, Bence Kozma, Michael Küchler, C. Herwig, Julian Kager · 2020 · Drug Discovery Today : Technologies
An adaptive soft‐sensor for advanced real‐time monitoring of an antibody‐drug conjugation reaction
Robin Schiemer, Jan Tobias Weggen, Katrin Marianne Schmitt, Jürgen J. Hubbuch · 2023 · Biotechnology and Bioengineering
Online prediction of product titer and solubility of recombinant proteins in Escherichia coli fed‐batch cultivations
Markus Luchner, Gerald Striedner, Monika Cserjan‐Puschmann, Florian Strobl, Karl Bayer · 2014 · Journal of Chemical Technology & Biotechnology
Studying pharmacodynamic effects in cell cultures by chemical fingerprinting − SIA electronic tongue versus 2D fluorescence soft sensor
Marcin Zabadaj, Aleksandra Szuplewska, Dominika Kalinowska, M. Chudy, Patrycja Ciosek · 2018 · Sensors and Actuators B Chemical
Soft Sensor-Based Monitoring and Efficient Control Strategies of Biomass Concentration for Continuous Cultures of Haloferax mediterranei and Their Application to an Industrial Production Chain
Thomas Mainka, Nicole Mahler, Christoph Herwig, Stefan Pflügl · 2019 · Microorganisms
Ex situonline monitoring: application, challenges and opportunities for biopharmaceuticals processes
Paul Kröll, Patrick Sagmeister, Wieland N. Reichelt, Lukas Neutsch, Tobias Klein, Christoph Herwig · 2014 · Pharmaceutical Bioprocessing
Fed-Batch Production of Bacterial Ghosts Using Dielectric Spectroscopy for Dynamic Process Control
Andrea Meitz, Patrick Sagmeister, Werner Lubitz, Christoph Herwig, Timo Langemann · 2016 · Microorganisms
A Perspective on PSE in Fermentation Process Development and Operation
2015 · Computer-aided chemical engineering/Computer aided chemical engineering
Bacterial Suspension Cultures
Patrick Sagmeister, Mohammadhadi Jazini, Joachim Klein, Christoph Herwig · 2014 · Wiley eBooks
Analysis of Transformed Upstream Bioprocess Data Provides Insights into Biological System Variation
Anne Richelle, Boung Wook Lee, Rui M. C. Portela, Jonathan Raley, Moritz von Stosch · 2020 · Biotechnology Journal
Model-Based Monitoring of Biotechnological Processes—A Review
Velislava Lyubenova, Georgi Atanasov Kostov, Rositsa Stefanova Denkova-Kostova · 2021 · Processes
Rapid monitoring of beer-quality attributes based on UV-Vis spectral data
Henrique Coelho de Oliveira, Júlio Cézar Elias Da Cunha Filho, José Celso Rocha, Eutímio Gustavo Fernández Núñez · 2017 · International Journal of Food Properties
Generalizability of Soft Sensors for Bioprocesses through Similarity Analysis and Phase-Dependent Recalibration
Manuel Siegl, Manuel Kämpf, Dominik Geier, Björn Andreeßen, Sebastian Max, Michael Zavrel, Thomas Matthias Becker · 2023 · Sensors
A Microfluidic Toolbox for the Development of In-Situ Product Removal Strategies in Biocatalysis
Søren Heintz, Aleksandar Mitic, Rolf Hoffmeyer Ringborg, Ulrich Krühne, John M. Woodley, Krist V. Gernaey · 2016 · Journal of Flow Chemistry
Observability-based sensor selection in fish ponds: Application to pond aquaculture in Indonesia
Bagoes Muhammad Inderaja, Nurhayati Br Tarigan, M.C.J. Verdegem, Karel J. Keesman · 2022 · Aquacultural Engineering
Nanomaterials and printing techniques for 2D and 3D soft electronics
Lorenzo Migliorini, Sara Moon Villa, Tommaso Santaniello, Paolo Milani · 2022 · Nano Futures
Design of a Soft Sensor for Monitoring Phosphorous Uptake in an EBPR Process
Wenjin Zhang, Stephany P. Wei, Mari K.H. Winkler, Amy V. Mueller · 2022 · ACS ES&T Engineering
Fed-Batch Fermentation – Design Strategies
Silvia Ochoa · 2019 · Elsevier eBooks
Modelling of the oxygen level response to feed rate perturbations in an industrial scale fermentation process
Ola Johnsson, Jonas Andersson, Gunnar Lidén, Charlotta Johnsson, Tore J. Hägglund · 2015 · Process Biochemistry
Present Status of Automation for Industrial Bioprocesses
Rudolf Hausmann, Marius Henkel, Florian T. Hecker, Bernd Hitzmann · 2016 · Elsevier eBooks
The need for smart microalgal bioprospecting
Joan Labara Tirado, Andrei Herdean, Peter J. Ralph · 2025 · Natural Products and Bioprospecting
Enabler for process analytical technology implementation in Pichia pastoris fermentation: Fluorescence‐based soft sensors for rapid quantitation of product titer
Viki Chopda, Mili Pathak, Jyoti Batra, James Gomes, Anurag Singh Rathore · 2016 · Engineering in Life Sciences
On-line monitoring of industrial interest Bacillus fermentations, using impedance spectroscopy
Adrián Díaz Pacheco, Jabel Dinorín Téllez Girón, Francisco Javier Martínez Montes, Shirlley E. Martínez Tolibia, Víctor Eric López y López · 2021 · Journal of Biotechnology
Investigating dielectric spectroscopy and soft sensing for nondestructive quality assessment of engineered tissues
Shohanuzzaman Shohan, Yingyan Zeng, Xiaoyu Chen, Ran Jin, Rohan A. Shirwaiker · 2022 · Biosensors and Bioelectronics
Recent Developments in Bioprocess Monitoring Systems
Vida Rahmatnejad, Yunqian Wei, Govind Rao · 2023 · Cell engineering
A Tool for On‐Line Monitoring Microalgal Bioprocesses Based on Gas Balance Analysis
Guillaume Cogne, Fernando Robert Ferrel Ballestas, Mariana Titica, Jack Legrand · 2025 · Biotechnology and Bioengineering
Stability analysis of slug flow control
Adegboyega Bolu Ehinmowo, Yi Cao · 2016 · Systems Science & Control Engineering
Multiobjective Optimization for Enhanced Production of Therapeutic Proteins in Escherichia coli: Application of Real-Time Dielectric Spectroscopy
Nivedhitha Swaminathan, Priyanka Priyanka, Anurag Singh Rathore, Senthilkumar Sivaprakasam, Senthilmurugan Subbiah · 2020 · Industrial & Engineering Chemistry Research
Quantitative spectral electromechanical characterization of soft piezoelectric nanocomposites
Sara Moon Villa, Mirko Maturi, Tommaso Santaniello, Lorenzo Migliorini, Erica Locatelli, Mauro Comes Franchini, Paolo Milani · 2021 · Sensors and Actuators A Physical
Current Developments in Industrial Fermentation Processes
Mehrdad Niakousari, Maryam Razmjooei, Maryam Nejadmansouri, Francisco J. Barba, Krystian Marszałek, Mohamed Koubaa · 2021 · Wiley eBooks
Computational Strategies for Maximizing Biomass and Metabolite Yields for Bioproduction
Yogesh Kumar Ahlawat, Vanshika Srivastava, Maryam Samani, Sarahani Harun, Vinothienii Rajuloo, Darshna Chaudhary · 2024 · Sustainable landscape planning and natural resources management
An Analysis of Monitoring Solutions for CAR T Cell Production
Arber Shoshi, Yuchen Xia, Andrea Fieschi, Yannick Baumgarten, Andrea Gaißler, Thomas Ackermann, Peter Reimann, Bernhard Mitschang, Michael Weyrich, Thomas Bauernhansl et al. · 2025 · Healthcare Technology Letters
Data synchronization techniques and their impact on the prediction performance of automated recalibrated soft sensors in bioprocesses
Manuel Siegl, Dominik Geier, Björn Andreeßen, Sebastian Max, Esther Mose, Michael Zavrel, Thomas Matthias Becker · 2024 · Biotechnology and Bioprocess Engineering
Significant roles of smart sensors in the modern agriculture and food industry
Sebahattin Serhat Turgut, Gonca Bilge, José Antonio Entrenas, Dolores Pérez‐Marín · 2024 · Elsevier eBooks
Soft sensor for viable cell counting by measuring dynamic oxygen uptake rate
M. Winter, Lena Achleitner, Peter Satzer · 2024 · New Biotechnology
Control of specific carbon dioxide production in a fed-batch culture producing recombinant protein using a soft sensor
Robert Gustavsson, Cornelia Lukasser, Carl‐Fredrik Mandenius · 2015 · Journal of Biotechnology
Modeling of Production and Quality of Bioethanol Obtained from Sugarcane Fermentation Using Direct Dissolved Sugars Measurements
B. Velázquez-Martí, Sergio Pérez, Juan Gaibor‐Chávez, Paola Wilcaso · 2016 · Energies
Implementing Process Analytical Technology for the Production of Recombinant Proteins in Escherichia coli Using an Advanced Controller Scheme
Priyanka Priyanka, Jashwant Kumar, James Gomes, Anurag Singh Rathore · 2019 · Biotechnology Journal
An Advanced Monitoring Platform for Rational Design of Recombinant Processes
Gerald Striedner, K. Bayer · 2012 · Advances in biochemical engineering, biotechnology
Bridging Offline Functional Model Carrying Aging-Specific Growth Rate Information and Recombinant Protein Expression: Entropic Extension of Akaike Information Criterion
Renaldas Urniežius, Benas Kemesis, Rimvydas Simutis · 2021 · Entropy
Software Sensors for Biomass Concentration Estimation in Filamentous Microorganism Cultivation Process
Pavel Hrnčiřı́k, Tomáš Moucha, Jan Mareš, J. Náhlík, Dagmar Janáčová · 2019 · Chemical and Biochemical Engineering Quarterly
Advances in modeling analysis for multi-parameter bioreactor process control
Xin Lin, Ke Li, Changzhe Wu, Cheng Zhang, Guanghao Zhang, Xiaolin Huo · 2025 · Biotechnology and Bioprocess Engineering
Current status and opportunities in adaptive data analysis for therapeutic cell manufacturing
Zhaonan Liu, Jialei Chen, Kan Wang, Ben Wang, Chuck Zhang · 2021 · Current Opinion in Biomedical Engineering
Mechanistic soft-sensor design for protein refolding processes based on intrinsic fluorescence measurements
Chika Linda Igwe, Florian Gisperg, Matthias Kierein, Eva Přáda Brichtová, Oliver Spadiut A, Don Fabian Müller · 2024 · Computers & Chemical Engineering
Monitoring of Fermentation and Biotechnological Processes
Alisa M. Rudnitskaya, Dmitry O. Kirsanov, Andrey V. Legin · 2016 · Elsevier eBooks
Feed-forward-based software sensor for outlet turbidity of coagulation process considering plug flow condition
Wei Liu, Harsha Chandima Ratnaweera · 2017 · International Journal of Environmental Science and Technology
A convenient new method for reproducible fed-batch fermentation of fission yeast Schizosaccharomyces pombe
Alberto Scomparin, Matthias Bureik · 2020 · Biotechnology Letters
Monitoring of Biopolymer Production Process Using Soft Sensors Based on Off-Gas Composition Analysis and Capacitance Measurement
Pavel Hrnčiřı́k · 2021 · Fermentation
Development of soft sensors for monitoring and control of bioprocesses
Robert Gustavsson · 2018
Monitoring Product Quantity, Purity and Potency of Biopharmaceuticals in Real-time by Predictive Chemometrics and Soft sensors
Astrid Dürauer, Alois Jungbauer, Theresa Scharl · 2023
Graph neural networks for soft sensors: Learning from process topology and operational data
Maximilian F. Theisen, Gabrie M.H. Meesters, Artur M. Schweidtmann · 2025 · Computers & Chemical Engineering
Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor
Amir M. Behdani, Yuxiang Zhao, Grace Yao, Dhanuka P. Wasalathanthri, Eric Hodgman, Michael Borys, Gloria Li, Anurag Khetan, Dayanjan Shanaka Wijesinghe, Anthony M. Leone · 2024 · Biotechnology Progress
Comparative Study of Intelligent Soft-Sensors for Bioprocess State Estimation
Rimvydas Simutis, Vytautas Galvanauskas, Donatas Levišauskas, Jolanta Repšytė, Vygandas Vaitkus · 2013 · Journal of Life Sciences and Technologies
Indirect Monitoring of Anaerobic Digestion for Cheese Whey Treatment
Hilario Flores-Mejia, Antonio Lara-Musule, Eliseo Hernández‐Martínez, Ricardo Aguilar‐López, Héctor Puebla · 2021 · Processes
Modeling for Process Risk Assessment in Industrial Bioprocesses
Robert Spann, Anna Eliasson Lantz, Krist V. Gernaey, Gürkan Sin · 2018 · Elsevier eBooks
Realization of user‐friendly bioanalytical tools to quantify and monitor critical components in bio‐industrial processes through conceptual design
Carl‐Fredrik Mandenius · 2021 · Engineering in Life Sciences
Multivariate Modeling for Bioreactor Monitoring and Control
Jarka Glassey · 2016
A Framework for Digital Technologies Application in Soft Sensing Monitoring to Recombinant Nanobody Production in Escherichia coli : From Model Explanation to the Study of Potential Scenario
Juan Camilo Acosta-Pavas, David Camilo Corrales, Susana María Alonso Villela, Georgios K. Georgakilas, Luc Fillaudeau, César Arturo Aceves-Lara · 2026 · ACS Omega
Extension of first principle elemental balancing soft-sensors by nonlinear reaction kinetics for increased robustness in bioprocess monitoring
Don Fabian Müller, Daniel Wibbing, Julian Kager · 2024 · Bioprocess and Biosystems Engineering
Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations
Karen Schwab, Friedemann Hesse · 2017 · Bioengineering
Filling the gap: Comparison of proxy measurement techniques for small data scenarios
Dominik Seiler, Garret E. O’Donnell · 2020 · Journal of Cleaner Production
Online Control Strategies
Inês A. Isidro, Daniel A. M. Pais, Paula M. Alves, Manuel J.T. Carrondo · 2019 · Elsevier eBooks
Online Control Strategies
Ana P. Teixeira, Rui Oliveira, Paula M. Alves, Manuel J.T. Carrondo · 2011 · Elsevier eBooks
Incorporation of error propagation into an elemental balancing based soft-sensor for improved online monitoring of microbial fed-batch processes
Don Fabian Müller, Konrad Lagoda, Daniel Wibbing, Christoph Herwig, Julian Kager · 2022 · Computer-aided chemical engineering/Computer aided chemical engineering
Extremum-seeking Control of Industrial-scale Fermentation Processes
Ola Johnsson · 2013 · Lund University Publications (Lund University)
A generative model-based coevolutionary training framework for noise-tolerant softsensors in wastewater treatment processes
Yu Peng, Erchao Li · 2025 · Complex & Intelligent Systems
A decade of innovation in healthcare: Automation, bio-printing and digital twin technologies for personalized therapies
Donya Ghavami, Nicola Giulietti, Giuseppina Sandri, Hermes Giberti · 2026 · International Journal of Pharmaceutics X
Developments and Trends in Industrial Process Analytics for Life Science Applications
Martin Gerlach, Reinhard Gross, Thomas Steckenreiter, Jens Traenkle, Albert Tulke · 2017 · ChemBioEng Reviews
Viable cell estimation of mammalian cells using off-gas-based oxygen uptake rate and aging-specific functional
Arnas Survyla, Renaldas Urniežius, Rimvydas Simutis · 2022 · Talanta
Soft-Sensing Estimation of Optical Density for PHA Production Using Multilayer Perceptron Neural Network
Nor Hana Mamat, Samsul Bahari Mohd Noor, Azura Che Soh, Farah Saleena Taip, Ahmad Hazri Ab Rashid, Nur Liyana Jufika Ahmad, Ishak Mohd Yusoff, Adida Zuraida Mohamad · 2020 · Journal of Physics Conference Series
Software Sensors for the Monitoring of Bioprocesses
Pavel Hrnčiřı́k · 2020 · Advances in intelligent systems and computing
Modeling a Virtual Flow Sensor in a Sugar-Energy Plant using Artificial Neural Network
Jayne dos Santos Lima, Juan Moisés Maurício Villanueva, Sebastian Yuri Cavalcanti Catunda · 2022 · IEEE International Instrumentation and Measurement Technology Conference
Soft Sensor Design for Bioreactor Monitoring and Control
Carl‐Fredrik Mandenius, Robert Gustavsson · 2016 · Wiley eBooks
Development of Soft Sensors for Monitoring of Chinese Hamster Ovary Cell Processes
Seyed Kaveh Ohadi · 2014 · UWSpace (University of Waterloo)
Consistent Value Creation from Bioprocess Data with Customized Algorithms: Opportunities Beyond Multivariate Analysis
Harini Narayanan, Moritz von Stosch, Martin Francisco Luna, Mariano Nicolás Cruz Bournazou, Alessandro Butté, Michael Sokolov · 2021 · Wiley eBooks
Hidden state estimation in stochastic integro-differential Amari model by adaptive singly diagonally implicit two-step peer triples with global error control
Gennady Yu. Kulikov, R. Weiner, Maria Vyacheslavovna Kulikova · 2024 · Digital Signal Processing
Real‐Time Biomass Estimation in High‐Density Yeast Fermentations Using Soft Sensor Modeling
Ana G Del Hierro, José Luis Checa-Barrera, Juan A. Moreno-Cid, Eoin Casey · 2026 · Biotechnology and Bioengineering
Advancing process control toward intelligent continuous biopharmaceutical manufacturing: Challenges, strategies, and future directions
Dongkyu Kim, Siyang Park, Chaeeun Lee, Cheol-Hwan Park, Daehwan Kim, Dong-Yup Lee, Moo Sun Hong · 2026 · Biotechnology Advances
Entwicklungen und Trends in der industriellen Prozessanalytik für Life‐Science‐Anwendungen
Martin Gerlach, Reinhard Gross, Thomas Steckenreiter, Jens Traenkle, Albert Tulke · 2016 · Chemie Ingenieur Technik
Mechanistic Models for Process Development and Optimization of Fed-batch Fermentation Systems
2016 · Computer-aided chemical engineering/Computer aided chemical engineering
Perfusion Mammalian Cell Culture for Recombinant Protein Manufacturing
Moritz Wolf, Jean‐Marc Bielser, Massimo Morbidelli · 2020 · Cambridge University Press eBooks
Scale-Down Models and Sensors for Process Development
Moritz Wolf, Jean‐Marc Bielser, Massimo Morbidelli · 2020 · Cambridge University Press eBooks
Bioreactors: A Biological and Bioengineering Prodigy
Komal Agrawal, Maulin Pramod Shah, Pradeep Verma · 2021 · Royal Society of Chemistry eBooks
Implementation and Optimization of a Data-Driven Soft Sensor in a Welding Process
Fabian Hensler, Alexander Jesser, Nico Strebe · 2023 · International Conference on Software Engineering and Computer Science (CSECS)
Controlling Uncertainty in Hydraulic Drive Systems by Means of a Soft Sensor Network
Christian Schänzle, Ingo Dietrich, Tobias Corneli, Peter F. Pelz · 2017 · Conference proceedings of the Society for Experimental Mechanics
Design and Optimisation of Mammalian Cell Perfusion Cultures
Moritz Wolf, Jean‐Marc Bielser, Massimo Morbidelli · 2020 · Cambridge University Press eBooks
Software Sensors for Monitoring of Biopolymer Production
Pavel Hrnciri · 2021 · International Conference on Process Control
Estimación y control de procesos biotecnológicos multivariables
Sebastián Núñez · 2014
Perturbation-based Control of Industrial Fed-batch Bioprocesses
Ola Johnsson · 2015 · Lund University Publications (Lund University)