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Rheology of hyaluronic acid
Abstract
The dynamic viscoelastic properties of hyaluronic acid solutions have been measured over the frequency range 0.02–1.67 cps. The effects of varying temperature, hyaluronic acid concentration, pH, and ionic strength on the dynamic shear moduli were studied. The solutions exhibited a sharp transition from viscous to elastic behavior as the strain frequency increased. No entanglement coupling of the hyaluronic acid molecules was evident over the concentration range 2.0–4.0 mg./ml. Solutions at pH 2.5 showed a pronounced elastic behavior relative to both higher and lower pH's. This effect was attributed to a stiffening of the hyaluronic acid molecule at this pH.
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Williams, M. L., Landel, R. F., & Ferry, J. D. (1955) · Journal of the American Chemical Society · doi:10.1021/ja01619a008 · Cited by 8,083
Cited by
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Clark, A. H., & Ross-Murphy, S. B. (2005) · Advances in Polymer Science · doi:10.1007/bfb0023332 · Cited by 1,299
Biodegradable Hydrogels for Drug Delivery
Park, H., Park, K., & Shalaby, W. S. W. (1993) · CRC Press eBooks · doi:10.1201/9780429259098 · Cited by 697
Structure, Conformation, and Mechanism in the Formation of Polysaccharide Gels and Networks
Rees, D. A. (1969) · Advances in Carbohydrate Chemistry and Biochemistry · doi:10.1016/s0065-2318(08)60352-2 · Cited by 658
The structure and function of hyaluronan: An overview
LAURENT, T. C., LAURENT, U. B., & FRASER, J. R. E. (1996) · Immunology & Cell Biology · doi:10.1038/icb.1996.32 · Cited by 503
Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin
Brown, M., & Jones, S. (2005) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2004.01180.x · Cited by 373
Metadata
- Authors
- Gibbs, D. A., Merrill, E. W., Smith, K. A., & Balazs, E. A.
- Venue
- Biopolymers
- Publisher
- Wiley
- Published
- 1968-06
- Volume
- 6
- Issue
- 6
- Pages
- 777-791
- ISSN
- 0006-3525 (ISSN-L)
- 1097-0282
- OpenAlex
- W2107778417
- Cited by
- 283
- References
- 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gibbs, D. A., Merrill, E. W., Smith, K. A., & Balazs, E. A. (1968). Rheology of hyaluronic acid. Biopolymers. https://doi.org/10.1002/bip.1968.360060603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
