The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The structure and function of hyaluronan: An overview
Abstract
Summary: Hyaluronan is a major component of synovial tissue and fluid as well as other soft connective tissues. It is a high‐Mr polysaccharide which forms entangled networks already at dilute concentrations (< 1 mg/mL) and endows its solutions with unique rheological properties. Physiological functions of hyaluronan (lubrication, water homeostasis. macromolecular filtering, exclusion, etc.) have been ascribed to the properties of these networks. Recently a number of specific interactions between hyaluronan and a group of proteins named hyaladherins have also pointed towards a role of hyaluronan in recognition and the regulation of cellular activities. Many more or less well documented hypotheses have been proposed for the function of hyaluronan in joints, for example, that it should lubricate, protect cartilage surfaces, scavenge free radicals and debris, keep the joint cavities open, form flow barriers in the synovium and prevent capillary growth.
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Self-citationCD44 and Its Interaction with Extracellular Matrix
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Physiological function of connective tissue polysaccharides.
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Self-citationHyaluronan‐binding proteins in development, tissue homeostasis, and disease
Knudson, C. B., & Knudson, W. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.13.7691670 · Cited by 649
The specific interaction of hyaluronic acid with cartilage proteoglycans.
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Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression
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Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
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Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
The Content and Size of Hyaluronan in Biological Fluids and Tissues
Cowman, M. K., Lee, H.-G., Schwertfeger, K. L., McCarthy, J. B., & Turley, E. A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00261 · Cited by 346
Recent advances in hyaluronic acid based therapy for osteoarthritis
Bowman, S., Awad, M. E., Hamrick, M. W., Hunter, M., & Fulzele, S. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0180-3 · Cited by 288
Aravamudhan, A., Ramos, D. M., Nada, A. A., & Kumbar, S. G. (2014) · Natural and Synthetic Biomedical Polymers · doi:10.1016/b978-0-12-396983-5.00004-1 · Cited by 238
Emerging Roles for Hyaluronidase in Cancer Metastasis and Therapy
(2014) · Advances in Cancer Research · doi:10.1016/b978-0-12-800092-2.00001-0 · Cited by 204
Metadata
- Authors
- LAURENT, T. C., LAURENT, U. B., & FRASER, J. R. E.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 1996-04
- Volume
- 74
- Issue
- 2
- Pages
- A1-7
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2009275174
- Cited by
- 503
- References
- 41
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The structure and function of hyaluronan: An overview. https://app.cochat.ai/papers/10.1038/icb.1996.32
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- LAURENT, T. C., LAURENT, U. B., & FRASER, J. R. E. (1996). The structure and function of hyaluronan: An overview. Immunology & Cell Biology. https://doi.org/10.1038/icb.1996.32
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
