Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 485

The DOI matches its Crossref record.

Preparation, optimization, and structures of cross‐linked enzyme aggregates (CLEAs)

Schoevaart, R., Wolbers, M.W., Golubovic, M., Ottens, M., Kieboom, A.P.G., van Rantwijk, F., van der Wielen, L.A.M., Sheldon, R.A.·2004·Biotechnology and Bioengineering
DOI 10.1002/bit.20184
Open this paper in CoChat — free account

Abstract

The broad applicability of the cross‐linking of enzyme aggregates to the effective immobilisation of enzymes is demonstrated and the influence of many parameters on the properties of the resulting CLEAs is determined. The relative simplicity of the operation ideally lends itself to high‐throughput methodologies. The aggregation method was improved up to 100% activity yield for any enzyme. For the first time, the physical structures of CLEAs are elucidated. © 2004 Wiley Periodicals, Inc.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/bit.20184

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cited by

See all 485

Metadata

Authors
Schoevaart, R., Wolbers, M. W., Golubovic, M., Ottens, M., Kieboom, A. P. G., van Rantwijk, F., van der Wielen, L. A. M., & Sheldon, R. A.
Venue
Biotechnology and Bioengineering
Publisher
Wiley
Published
2004-08-19
Volume
87
Issue
6
Pages
754-762
ISSN
  • 0006-3592 (ISSN-L)
  • 1097-0290
DOI
10.1002/bit.20184
OpenAlex
W2030974312
Cited by
485
References
0
FWCI
3.94
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Preparation, optimization, and structures of cross‐linked enzyme aggregates (CLEAs). https://app.cochat.ai/papers/10.1002/bit.20184
The paper
Schoevaart, R., Wolbers, M. W., Golubovic, M., Ottens, M., Kieboom, A. P. G., van Rantwijk, F., van der Wielen, L. A. M., & Sheldon, R. A. (2004). Preparation, optimization, and structures of cross‐linked enzyme aggregates (CLEAs). Biotechnology and Bioengineering. https://doi.org/10.1002/bit.20184

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.