The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Immobilized N‐alkylated polyethylenimine avidly kills bacteria by rupturing cell membranes with no resistance developed
Abstract
Several critical mechanistic and phenomenological aspects of the microbicidal surface coatings based on immobilized hydrophobic polycations, previously developed by us, are addressed. Using Escherichia coli (Gram‐negative) and Staphylococcus aureus (Gram‐positive) bacteria, remarkable bactericidal action (up to a 10 9‐fold reduction in live bacteria count in the surface‐exposed solution and a 100% inactivation of the surface‐adhered bacteria) of an amino‐glass slide covalently derivatized with N‐hexyl,methyl‐polyethylenimine (PEI) is found to be due to rupturing bacterial cell membranes by the polymeric chains. The bacteria fail to develop noticeable resistance to this lethal action over the course of many successive generations. Finally, the immobilized N‐alkyl‐PEI, while deadly to bacteria, is determined to be harmless to mammalian (monkey kidney) cells. © 2005 Wiley Periodicals, Inc.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Agents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
Permanent, nonleaching antibacterial surfaces: 1. Synthesis by atom transfer radical polymerization
Lee, S. B., Koepsel, R. R., Morley, S. W., Matyjaszewski, K., Sun, Y., & Russell, A. J. (2004) · Biomacromolecules · doi:10.1021/bm034352k · Cited by 545
Surface-bonded antimicrobial activity of an organosilicon quaternary ammonium chloride
Isquith, A. J., Abbott, E. A., & Walters, P. A. (1972) · Applied Microbiology · doi:10.1128/aem.24.6.859-863.1972 · Cited by 329
Cited by
Banerjee, I., Pangule, R. C., & Kane, R. S. (2011) · Advanced Materials · doi:10.1002/adma.201001215 · Cited by 2,749
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Self-citationMurata, H., Koepsel, R. R., Matyjaszewski, K., & Russell, A. J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.012 · Cited by 722
Antimicrobial polymers: mechanism of action, factors of activity, and applications
Timofeeva, L., & Kleshcheva, N. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2920-9 · Cited by 579
Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts
Xue, Y., Xiao, H., & Zhang, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023626 · Cited by 578
Metadata
- Authors
- Milović, N. M., Wang, J., Lewis, K., & Klibanov, A. M.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 2005-03-31
- Volume
- 90
- Issue
- 6
- Pages
- 715-722
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W2164679906
- Cited by
- 315
- References
- 4
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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