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Cytocompatibility, interactions, and uptake of polyethyleneimine‐coated boron nitride nanotubes by living cells: Confirmation of their potential for biomedical applications
Abstract
Boron nitride nanotubes (BNNTs) have unique physical properties, which can be exploited in the biomedical field. Hence, the surprising lack of reported studies on their biocompatibility and interactions with living cells, addressed by the present paper which deals the results of such an investigation based on 72 h culture of human neuroblastoma cell line (SH‐SY5Y) in the presence of an aqueous suspension of polyethyleneimine (PEI)‐coated BNNTs. BNNTs conjugated with fluorescent markers (quantum dots) are employed to enable tracking of their uptake by living cells. The results demonstrate good cytocompatibility together with unequivocal BNNT cellular uptake by an energy‐dependent endocytic process. Biotechnol. Bioeng. 2008;101: 850–858. © 2008 Wiley Periodicals, Inc.
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Nesti, E., Everill, B., & Morielli, A. D. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0788 · Cited by 94
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Weng, Q., Wang, B., Wang, X., Hanagata, N., Li, X., Liu, D., Wang, X., Jiang, X., Bando, Y., & Golberg, D. (2014) · ACS Nano · doi:10.1021/nn5014808 · Cited by 455
Boron nitride nanomaterials: biocompatibility and bio-applications
Merlo, A., Mokkapati, V. R. S. S., Pandit, S., & Mijakovic, I. (2018) · Biomaterials Science · doi:10.1039/c8bm00516h · Cited by 282
Metadata
- Authors
- Ciofani, G., Raffa, V., Menciassi, A., & Cuschieri, A.
- Venue
- Biotechnology and Bioengineering
- Publisher
- Wiley
- Published
- 2008-09-23
- Volume
- 101
- Issue
- 4
- Pages
- 850-858
- ISSN
- 0006-3592 (ISSN-L)
- 1097-0290
- OpenAlex
- W2125344820
- Cited by
- 235
- References
- 1
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ciofani, G., Raffa, V., Menciassi, A., & Cuschieri, A. (2008). Cytocompatibility, interactions, and uptake of polyethyleneimine‐coated boron nitride nanotubes by living cells: Confirmation of their potential for biomedical applications. Biotechnology and Bioengineering. https://doi.org/10.1002/bit.21952
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