Somatostatin analogue SMS 201–995 (octreotide) as a possible solution to the dumping syndrome after gastrectomy or vagotomy
Abstract
The dumping syndrome, which may follow partial gastrectomy or truncal vagotomy and drainage, may be refractory to treatment. The aim of this study was to determine the effect of the somatostatin analogue, SMS 201-995 (octreotide), on dumping provoked by hypertonic glucose. Ten patients with symptoms and signs of dumping were studied. After a dumping provocation test with placebo, all patients developed severe symptoms: seven patients had early dumping, two had both early and late dumping and one had late dumping alone. With either 50 or 100 micrograms SMS 201-995, the symptoms of early dumping were much reduced in all patients, and those of late dumping were completely abolished. The packed cell volume, pulse and systolic blood pressure changes of early dumping were significantly reduced by SMS 201-995 and the fall in blood glucose in patients with late dumping was abolished. SMS 201-995 may be a useful treatment for early and late dumping.
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Short-acting formulations may be more effective at improving some dumping symptoms such as hypoglycemia.
“Short-acting formulations may be more effective at improving some dumping symptoms such as hypoglycemia (15,(81)(82)(83)85); however, the need for repeated injections throughout the day is often a major limitation to the long-term administration of short-acting”
From Dumping syndrome after esophageal, gastric or bariatric surgery: Pathophysiology, diagnosis, and management (2017) · cites this paper as [81]
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- Authors
- Primrose, J. N., & Johnston, D.
- Affiliations
- University Department of Surgery, The General Infirmary , Leeds,
- Leeds General Infirmary (GB)
- ORCID
- Johnston, D
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-02-01
- Volume
- 76
- Issue
- 2
- Pages
- 140-144
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2028376447
- Cited by
- 40
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 1 · 2016: 2 · 2015: 1 · 2012: 1
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- British journal of surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- dumping syndrome, octreotide, somatostatin analogues, partial gastrectomy, truncal vagotomy, hypertonic glucose, hypoglycemia, blood pressure response
- MeSH terms
- Adult, Animals, Chick Embryo, Dumping Syndrome, Female, Gastrectomy, Glucose Solution, Hypertonic, Hematocrit, Humans, Male, Middle Aged, Time Factors, Vagotomy, Octreotide
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