The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
Abstract
Background: Sarcopenia was identified recently as a poor prognostic factor in patients with cancer. The present study investigated the effect of sarcopenia on short- and long-term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors. Methods: Data were collected retrospectively for all consecutive patients who underwent hepatectomy for HCC with curative intent between January 2004 and December 2009. Patients were assigned to one of two groups according to the presence or absence of sarcopenia, assessed by computed tomographic measurement of muscle mass at the level of the third lumbar vertebra. Clinicopathological, surgical outcome and long-term survival data were analysed. Results: Sarcopenia was present in 75 (40·3 per cent) of 186 patients, and was significantly correlated with female sex, lower body mass index and liver dysfunction, as indicated by abnormal serum albumin levels and indocyanine green retention test at 15 min values. In patients with, and without sarcopenia, the 5-year overall survival rate was 71 and 83·7 per cent respectively, and the 5-year recurrence-free survival rate was 13 and 33·2 per cent respectively. Multivariable analysis revealed that reduced skeletal muscle mass was predictive of an unfavourable prognosis. Conclusion: Sarcopenia was predictive of worse overall survival even when adjusted for other known predictors in patients with HCC after partial hepatectomy.
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Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
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Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Late evening snack: exploiting a period of anabolic opportunity in cirrhosis
Tsien, C. D., McCullough, A. J., & Dasarathy, S. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06951.x · Cited by 252
Cited by
EASL Clinical Practice Guidelines on nutrition in chronic liver disease
Merli, M., Berzigotti, A., Zelber-Sagi, S., Dasarathy, S., Montagnese, S., Genton, L., Plauth, M., & Parés, A. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.024 · Cited by 1,130
Eslam, M., Sarin, S. K., Wong, V. W.-S., Fan, J.-G., Kawaguchi, T., Ahn, S. H., Zheng, M.-H., Shiha, G., Yilmaz, Y., Gani, R., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10094-2 · Cited by 833
Simonsen, C., de Heer, P., Bjerre, E. D., Suetta, C., Hojman, P., Pedersen, B. K., Svendsen, L. B., & Christensen, J. F. (2018) · Annals of Surgery · doi:10.1097/sla.0000000000002679 · Cited by 375
Sarcopenia: Current Concepts and Imaging Implications
Boutin, R. D., Yao, L., Canter, R. J., & Lenchik, L. (2015) · American Journal of Roentgenology · doi:10.2214/ajr.15.14635 · Cited by 323
Levolger, S., van Vugt, J. L. A., de Bruin, R. W. F., & IJzermans, J. N. M. (2015) · British Journal of Surgery · doi:10.1002/bjs.9893 · Cited by 270
Metadata
- Authors
- Harimoto, N., Shirabe, K., Yamashita, Y.-I., Ikegami, T., Yoshizumi, T., Soejima, Y., Ikeda, T., Maehara, Y., Nishie, A., & Yamanaka, T.
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-04
- Volume
- 100
- Issue
- 11
- Pages
- 1523-1530
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2148227350
- Cited by
- 504
- References
- 5
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harimoto, N., Shirabe, K., Yamashita, Y.-I., Ikegami, T., Yoshizumi, T., Soejima, Y., Ikeda, T., Maehara, Y., Nishie, A., & Yamanaka, T. (2013). Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. British Journal of Surgery. https://doi.org/10.1002/bjs.9258
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