The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies
Abstract
Background: Preoperative risk assessment in cancer surgery is of importance to improve treatment and outcome. The aim of this study was to assess the impact of CT-assessed sarcopenia on short- and long-term outcomes in patients undergoing surgical resection of gastrointestinal and hepatopancreatobiliary malignancies. Methods: A systematic search of Embase, PubMed and Web of Science was performed to identify relevant studies published before 30 September 2014. PRISMA guidelines for systematic reviews were followed. Screening for inclusion, checking the validity of included studies and data extraction were carried out independently by two investigators. Results: After screening 692 records, 13 observational studies with a total of 2884 patients were included in the analysis. There was wide variation in the reported prevalence of sarcopenia (17·0–79 per cent). Sarcopenia was independently associated with reduced overall survival in seven of ten studies, irrespective of tumour site. Hazard ratios (HRs) of up to 3·19 (hepatic cancer), 1·63 (pancreatic cancer), 1·85 (colorectal cancer) and 2·69 (colorectal liver metastases, CLM) were reported. For oesophageal cancer, the HR was 0·31 for increasing muscle mass. In patients with colorectal cancer and CLM, sarcopenia was independently associated with postoperative mortality (colorectal cancer: odds ratio (OR) 43·3), complications (colorectal cancer: OR 0·96 for increasing muscle mass; CLM: OR 2·22) and severe complications (CLM: OR 3·12). Conclusion: Sarcopenia identified before surgery by single-slice CT is associated with impaired overall survival in gastrointestinal and hepatopancreatobiliary malignancies, and increased postoperative morbidity in patients with colorectal cancer with or without hepatic metastases.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
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Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
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Epidemiology of Sarcopenia among the Elderly in New Mexico
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Cited by
Baracos, V. E., & Arribas, L. (2018) · Annals of Oncology · doi:10.1093/annonc/mdx810 · Cited by 362
van Vugt, J. L. A., Levolger, S., de Bruin, R. W. F., van Rosmalen, J., Metselaar, H. J., & IJzermans, J. N. M. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13732 · Cited by 361
Self-citationRecent Issues on Body Composition Imaging for Sarcopenia Evaluation
Lee, K., Shin, Y., Huh, J., Sung, Y. S., Lee, I.-S., Yoon, K.-H., & Kim, K. W. (2019) · Korean Journal of Radiology · doi:10.3348/kjr.2018.0479 · Cited by 336
Kamarajah, S. K., Bundred, J., & Tan, B. H. L. (2019) · Gastric Cancer · doi:10.1007/s10120-018-0882-2 · Cited by 259
Prognostic Value of Sarcopenia in Lung Cancer
Yang, M., Shen, Y., Tan, L., & Li, W. (2019) · Chest · doi:10.1016/j.chest.2019.04.115 · Cited by 258
Metadata
- Authors
- Levolger, S., van Vugt, J. L. A., de Bruin, R. W. F., & IJzermans, J. N. M.
- Venue
- British Journal of Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09-16
- Volume
- 102
- Issue
- 12
- Pages
- 1448-1458
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W1828411566
- Cited by
- 270
- References
- 58
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Levolger, S., van Vugt, J. L. A., de Bruin, R. W. F., & IJzermans, J. N. M. (2015). Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies. British Journal of Surgery. https://doi.org/10.1002/bjs.9893
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