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Cited by 2,450

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Cachexia: A new definition

Open access
Evans, William J., Morley, John E., Argilés, Josep, Bales, Connie, Baracos, Vickie, Guttridge, Denis, Jatoi, Aminah, Kalantar-Zadeh, Kamyar, Lochs, Herbert, Mantovani, Giovanni, Marks, Daniel, Mitch, William E., Muscaritoli, Maurizio, Najand, Armine, Ponikowski, Piotr, Rossi Fanelli, Filippo, Schambelan, Morrie, Schols, Annemie, Schuster, Michael, Thomas, David, Wolfe, Robert, Anker, Stefan D.·2008·Clinical Nutrition

Abstract

On December 13th and 14th a group of scientists and clinicians met in Washington, DC, for the cachexia consensus conference. At the present time, there is no widely agreed upon operational definition of cachexia. The lack of a definition accepted by clinician and researchers has limited identification and treatment of cachectic patient as well as the development and approval of potential therapeutic agents. The definition that emerged is: "cachexia, is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass. The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders). Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia. Cachexia is distinct from starvation, age-related loss of muscle mass, primary depression, malabsorption and hyperthyroidism and is associated with increased morbidity. While this definition has not been tested in epidemiological or intervention studies, a consensus operational definition provides an opportunity for increased research.

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Metadata

Authors
Evans, W. J., Morley, J. E., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-Zadeh, K., Lochs, H., Mantovani, G., Marks, D., Mitch, W. E., Muscaritoli, M., Najand, A., Ponikowski, P., Rossi Fanelli, F., Schambelan, M., Schols, A., Schuster, M., Thomas, D., Wolfe, R., & Anker, S. D.
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2008-12
Volume
27
Issue
6
Pages
793-799
ISSN
0261-5614 (ISSN-L)
OpenAlex
W2003064100
Cited by
2,450
References
3
FWCI
57.91
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cachexia: A new definition. https://app.cochat.ai/papers/10.1016/j.clnu.2008.06.013
The paper
Evans, W. J., Morley, J. E., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-Zadeh, K., Lochs, H., Mantovani, G., Marks, D., Mitch, W. E., Muscaritoli, M., Najand, A., Ponikowski, P., Rossi Fanelli, F., Schambelan, M., Schols, A., Schuster, M., . . . Anker, S. D. (2008). Cachexia: A new definition. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2008.06.013

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.