Incidence and Management of Patients with Colorectal Cancer and Synchronous and Metachronous Colorectal Metastases: A Population-Based Study
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Background: This population-based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods: A retrospective population-based study was conducted on patients with metastatic colorectal cancer in Central Finland in 2000–2015. Clinical and histopathological data were retrieved and descriptive analysis was conducted to determine the pattern of metastatic disease, defined as synchronous, early metachronous (within 12 months of diagnosis of primary disease) and late metachronous (more than 12 months after diagnosis). Subgroups were compared for resection and overall survival (OS) rates. Results: Of 1671 patients, 296 (17·7 per cent) had synchronous metastases, and 255 (19·6 per cent) of 1302 patients with resected stage I–III tumours developed metachronous metastases (94 early and 161 late metastases). Liver, pulmonary and intraperitoneal metastases were the most common sites. The commonest metastatic patterns were a combination of liver and lung metastases. The overall metastasectomy rate for patients with synchronous metastases was 16·2 per cent; in this subgroup, 3- and 5-year OS rates after any resection were 63 and 44 per cent respectively, compared with 7·1 and 3·3 per cent following no resection (P < 0·001). The resection rate was higher for late than for early metachronous disease (28·0 versus 17 per cent respectively; P = 0·048). Three- and 5-year OS rates after any resection of metachronous metastases were 78 and 62 per cent respectively versus 42·1 and 18·2 per cent with no metastasectomy (P < 0·001). Similarly, 3- and 5-year OS rates after any metastasectomy for early metachronous metastases were 57 and 50 per cent versus 84 and 66 per cent for late metachronous metastases (P = 0·293). Conclusion: The proportion of patients with metastatic colorectal cancer was consistent with that in earlier population-based studies, as were resection rates for liver and lung metastases and survival after resection. Differentiation between synchronous, early and late metachronous metastases can improve assessment of resectability and survival.
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Around 33% of colorectal cancer patients will encounter metastases either at the time of diagnosis or during the course of their illness.
“Around 33% of CRC patients will encounter metastases either at the time of diagnosis or during the course of their illness [5].”
From KRAS, a New Target for Precision Medicine in Colorectal Cancer? (2024) · cites this paper as [5]
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. D., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 21,271 · see citing works
TNM Classification of Malignant Tumours
Hermanek, P., & Sobin, L. H. (1987) · Springer eBooks · doi:10.1007/978-3-642-82982-6 · Cited by 16,073 · see citing works
Global patterns and trends in colorectal cancer incidence and mortality
Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2016) · Gut · doi:10.1136/gutjnl-2015-310912 · Cited by 5,250 · see citing works
GLOBOCAN 2008 v1.2, Cancer incidence and mortality world-wide : IARC Cancer Base No. 10
Ferlay, J. (2010) · Medical Entomology and Zoology · Cited by 1,636 · see citing works
Schmoll, H., Cutsem, E. V., Stein, A., Valentini, V., Glimelius, B. L. G., Haustermans, K. M., Nordlinger, B., van de Velde, C. J., Balmañà, J., Reguła, J., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds236 · Cited by 1,509 · see citing works
Epidemiology and Management of Liver Metastases From Colorectal Cancer
Manfrédi, S., Lepage, C., Hatem, C., Coatmeur, O., Faivre, J., & Bouvier, A. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000217629.94941.cf · Cited by 1,394 · see citing works
Patterns of metastasis in colon and rectal cancer
Riihimäki, M., Hemminki, A., Sundquist, J., & Hemminki, K. (2016) · Scientific Reports · doi:10.1038/srep29765 · Cited by 964 · see citing works
Colorectal cancer liver metastases – a population-based study on incidence, management and survival
Engstrand, J., Nilsson, H., Strömberg, C., Jonas, E., & Freedman, J. (2018) · BMC Cancer · doi:10.1186/s12885-017-3925-x · Cited by 902 · see citing works
Adam, R. A., de Gramont, A., Figueras, J., Kokudo, N., Kunstlinger, F., Loyer, E. M., Poston, G. J., Rougier, P. R., Rubbia‐Brandt, L., Sobrero, A. F., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.06.006 · Cited by 609 · see citing works
Adam, R. A., de Gramont, A., Figueras, J., Guthrie, A. J., Kokudo, N., Kunstlinger, F., Loyer, E. M., Poston, G. J., Rougier, P. R., Rubbia‐Brandt, L., et al. (2012) · The Oncologist · doi:10.1634/theoncologist.2012-0121 · Cited by 584 · see citing works
Pfannschmidt, J., Dienemann, H., & Hoffmann, H. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.02.093 · Cited by 556 · see citing works
van der Geest, L. G., Lam-Boer, J. ‘., Koopman, M., Verhoef, C., Elferink, M. A. G., & de Wilt, J. H. W. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9719-0 · Cited by 531 · see citing works
Leporrier, J., Maurel, J., Chiche, L., Bara, S., Segol, P., & Launoy, G. D. (2006) · British journal of surgery · doi:10.1002/bjs.5278 · Cited by 455 · see citing works
Mitry, E., Guiu, B., Cosconea, S., Jooste, V., Faivre, J., & Bouvier, A. (2010) · Gut · doi:10.1136/gut.2010.211557 · Cited by 379 · see citing works
Patterns of metachronous metastases after curative treatment of colorectal cancer
van Gestel, Y. R. B. M., de Hingh, I. H. J. T., van Herk‐Sukel, M. P. P., van Erning, F. N., Beerepoot, L. V., Wijsman, J. H., Slooter, G. D., Rutten, H. J. T., Creemers, G., & Lemmens, V. E. P. P. (2014) · Cancer Epidemiology · doi:10.1016/j.canep.2014.04.004 · Cited by 234 · see citing works
Colorectal Cancer Liver Metastases and Concurrent Extrahepatic Disease Treated With Resection
Leung, U., Gönen, M., Allen, P. J., Kingham, T. P., DeMatteo, R. P., Jarnagin, W. R., & D'Angelica, M. I. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000001624 · Cited by 167 · see citing works
Pulitanò, C., Bodingbauer, M., Aldrighetti, L. A., Jong, M. C. D., Castillo, F., Schulick, R. D., Parks, R. W., Choti, M. A., Wigmore, S. J., Gruenberger, T., et al. (2010) · Annals of Surgical Oncology · doi:10.1245/s10434-010-1459-4 · Cited by 157 · see citing works
Surgical management of patients with colorectal cancer and simultaneous liver and lung metastases
Andrès, A., Mentha, G., Adam, R. A., Gerstel, E., Скипенко, О. Г., Barroso, E., López‐Ben, S., Hubert, C., Majno, P. E., & Toso, C. (2015) · British journal of surgery · doi:10.1002/bjs.9783 · Cited by 108 · see citing works
Cancer Recurrence: An Important but Missing Variable in National Cancer Registries
In, H., Bilimoria, K. Y., Stewart, A. K., Wroblewski, K., Posner, M. C., Talamonti, M. S., & Winchester, D. P. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3516-x · Cited by 101 · see citing works
Mantke, R., Schmidt, U., Wolff, S., Kube, R., & Lippert, H. (2011) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2011.12.013 · Cited by 76 · see citing works
Angelsen, J.-H., Horn, A., Sørbye, H., Eide, G. E., Løes, I. M., & Viste, A. (2017) · British journal of surgery · doi:10.1002/bjs.10457 · Cited by 62 · see citing works
Cardona, K., Mastrodomenico, P., D’Amico, F., Shia, J., Gönen, M., Weiser, M. R., Paty, P. B., Kingham, T. P., Allen, P. J., DeMatteo, R. P., et al. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2540-y · Cited by 51 · see citing works
Sequential surgical resection of hepatic and pulmonary metastases from colorectal cancer
Limmer, S., Oevermann, E., Killaitis, C., Kujath, P., Hoffmann, M., & Bruch, H. (2010) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-010-0595-4 · Cited by 46 · see citing works
A Nodal Positivity Constant: New Perspectives in Lymph Node Evaluation and Colorectal Cancer
Hogan, N. M., & Winter, D. C. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1891-7 · Cited by 27 · see citing works
What is the role of lymph node metastases in the progression of colorectal cancer?
Nagtegaal, I. D., & Schmoll, H. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.122 · Cited by 23 · see citing works
Laparoscopic Wide Mesocolic Excision and Central Vascular Ligation for Carcinoma of the Colon
Ehrlich, A., Kairaluoma, M. V., Böhm, J., Vasala, K., Kautiainen, H., & Kellokumpu, I. (2016) · Scandinavian Journal of Surgery · doi:10.1177/1457496915613646 · Cited by 8 · see citing works
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Cited by
Sorted by citations
Treatment of Metastatic Colorectal Cancer: ASCO Guideline
Morris, V. K., Kennedy, E. B., Baxter, N. N., Benson, A. B., Cercek, A., Cho, M., Ciombor, K. K., Cremolini, C., Davis, A., Deming, D. A., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.22.01690 · Cited by 682 · see citing works
Mechanisms of metastatic colorectal cancer
Cañellas-Socias, A., Sancho, E., & Batlle, E. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00934-z · Cited by 270 · see citing works
Stage IV Colorectal Cancer Management and Treatment
Dominguez, O. H., Yılmaz, S., & Steele, S. R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12052072 · Cited by 122 · see citing works
Osterlund, P. J., Salminen, T., Soveri, L., Kallio, R., Kellokumpu, I., Lamminmäki, A., Halonen, P., Ristamäki, R., Lantto, E., Uutela, A., et al. (2021) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2021.100049 · Cited by 114 · see citing works
Self-citationIncidence and Survival in Synchronous and Metachronous Liver Metastases From Colorectal Cancer
Reboux, N., Jooste, V., Goungounga, J. A., Robaszkiewicz, M., Nousbaum, J., & Bouvier, A. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.36666 · Cited by 109 · see citing works
Current Surgical Management Strategies for Colorectal Cancer Liver Metastases
Ivey, G. D., Johnston, F. M., Azad, N. S., Christenson, E. S., Lafaro, K. J., & Shubert, C. R. (2022) · Cancers · doi:10.3390/cancers14041063 · Cited by 70 · see citing works
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
Elomaa, H., Ahtiainen, M., Väyrynen, S. A., Ogino, S., Nowak, J. A., Friman, M., Helminen, O., Wirta, E., Seppälä, T. T., Böhm, J., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01822-6 · Cited by 66 · see citing works
Self-citationIsoniemi, H., Uutela, A., Nordin, A. J., Lantto, E., Kellokumpu, I., Ovissi, A., Kosunen, J., Kallio, R., Soveri, L., Salminen, T., et al. (2021) · British journal of surgery · doi:10.1093/bjs/znaa145 · Cited by 46 · see citing works
Self-citationElomaa, H., Ahtiainen, M., Väyrynen, S. A., Ogino, S., Nowak, J. A., Lau, M. C., Helminen, O., Wirta, E., Seppälä, T. T., Böhm, J., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02238-6 · Cited by 41 · see citing works
Self-citationCurrent and emerging concepts for systemic treatment of metastatic colorectal cancer
Steup, C., Kennel, K. B., Neurath, M. F., Fichtner-Feigl, S., & Greten, F. R. (2025) · Gut · doi:10.1136/gutjnl-2025-335412 · Cited by 39 · see citing works
Liu, S., Zhang, Z., Wang, Z., Liu, C. R., Liang, G., Xu, T., Li, Z., Duan, X., Xu, G., Feng, X., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4916 · Cited by 38 · see citing works
Rahbari, N. N., Biondo, S., Frago, R., Feißt, M., Kreisler, E., Rossion, I., Serrano-Navidad, M., Jäger, D., Lehmann, M., Sommer, F., et al. (2024) · Journal of Clinical Oncology · doi:10.1200/jco.23.01540 · Cited by 33 · see citing works
Colorectal Cancer Liver Metastases
Aykut, B., & Lidsky, M. E. (2022) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2022.07.009 · Cited by 31 · see citing works
Payervand, N., Pakravan, K., Razmara, E., Vinu, K. K., Ghodsi, S., Heshmati, M., & Babashah, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31584 · Cited by 26 · see citing works
HER2-targeted therapy in colorectal cancer: a comprehensive review
Benli, Y., Arıkan, H., & Akbulut, Ö. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03887-0 · Cited by 28 · see citing works
Ciardiello, D., Mauri, G., Bianchi, A. S., Siena, S., Zampino, M. G., Fazio, N., & Cervantes, A. M. R. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102683 · Cited by 22 · see citing works
Elomaa, H., Tarkiainen, V., Äijälä, V. K., Sirniö, P., Ahtiainen, M., Sirkiä, O., Karjalainen, H., Kastinen, M., Tapiainen, V. V., Rintala, J. M. J., et al. (2025) · British Journal of Cancer · doi:10.1038/s41416-025-02960-3 · Cited by 20 · see citing works
Self-citationEvolutionary paths towards metastasis
Naxerova, K. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00814-x · Cited by 19 · see citing works
Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases
Ahtiainen, M., Elomaa, H., Väyrynen, J. P., Wirta, E., Kuopio, T., Helminen, O., Seppälä, T. T., Kellokumpu, I., & Mecklin, J. (2021) · Cancers · doi:10.3390/cancers13071530 · Cited by 18 · see citing works
Self-citationTertiary lymphoid structures in pulmonary metastases of microsatellite stable colorectal cancer
Karjula, T., Niskakangas, A., Mustonen, O., Puro, I., Elomaa, H., Ahtiainen, M., Kuopio, T., Mecklin, J., Seppälä, T. T., Wirta, E., et al. (2023) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-023-03577-8 · Cited by 18 · see citing works
Self-citationGössling, G. C. D. L., Chedid, M. F., Pereira, F. S., Silva, R. K., de Andrade, L. B., Peruzzo, N., Saueressig, M. G., Schwartsmann, G., & Parikh, A. R. (2021) · The Oncologist · doi:10.1002/onco.13802 · Cited by 18 · see citing works
Benmokhtar, S., Laraqui, A., Hilali, F., Bajjou, T., Zaitouni, S. E., Jafari, M., Baba, W., Elannaz, H., Lahlou, I. A., Chahdi, H., et al. (2024) · Clinical Medicine Insights Oncology · doi:10.1177/11795549241255651 · Cited by 17 · see citing works
Wong, S. Q. R., Das, M., Tenzin, K., Shirgaonkar, N., Chua, H., Chee, L. X., Yeoh, A. S., Murugiah, A. A., Chua, W. Y., Theardy, M. S., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07855-y · Cited by 16 · see citing works
Optimizing Treatment Strategy for Oligometastases/Oligo-Recurrence of Colorectal Cancer
Yokoi, R., Tajima, J. Y., Fukada, M., Hayashi, H., Kuno, M., Asai, R., Sato, Y., Yasufuku, I., Kiyama, S., Tanaka, Y., et al. (2023) · Cancers · doi:10.3390/cancers16010142 · Cited by 16 · see citing works
Uutela, A., Ovissi, A., Hakkarainen, A., Ristimaki, A. P., Lundbom, N. M. I., Kallio, R., Soveri, L., Salminen, T., Ålgars, A., Halonen, P., et al. (2021) · ESMO Open · doi:10.1016/j.esmoop.2021.100208 · Cited by 16 · see citing works
Shi, S., Jiang, T., Liu, H., Wu, Y., Singh, A., Wang, Y., Xie, J., & Li, X. (2025) · Academic Radiology · doi:10.1016/j.acra.2025.02.046 · Cited by 17 · see citing works
Viot, J., Loyon, R., Adib, N., Laurent‐Puig, P., de Reyniès, A., André, F., Monnien, F., André, T., Svrcek, M., Turpin, A., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105727 · Cited by 14 · see citing works
Metachronous colorectal cancer metastasis: Who, what, when and what to do about it
Cohen, R., & Platell, C. F. E. (2023) · Journal of Surgical Oncology · doi:10.1002/jso.27400 · Cited by 12 · see citing works
Liver Metastases and Survival Among Patients With Colorectal Cancer
Johannsen, I. R., Boysen, A. K., Nielsen, M. F., Mortensen, F. V., & Kirkegård, J. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.50467 · Cited by 12 · see citing works
KRAS, a New Target for Precision Medicine in Colorectal Cancer?
Boilève, A., Smolenschi, C., Lambert, A., Boige, V., Delaye, M., Camilleri, G. M., Tarabay, A., Valéry, M., Fuerea, A., Pudlarz, T., et al. (2024) · Cancers · doi:10.3390/cancers16203455 · Cited by 11 · see citing works
Kanno, H., Hisaka, T., Akiba, J., Hashimoto, K., Fujita, F., & Akagi, Y. (2022) · BMC Cancer · doi:10.1186/s12885-022-09842-4 · Cited by 11 · see citing works
Almlöv, K., Arbman, G., Björnsson, B., Elander, N. O., Hager, J., Hamid, S., Landerholm, K., Loftås, P. I., & Sandström, P. (2024) · HPB · doi:10.1016/j.hpb.2024.05.008 · Cited by 11 · see citing works
Pape, M., Vissers, P. A. J., Bertwistle, D., McDonald, L., Slingerland, M., Mohammad, N. H., Beerepoot, L. V., Ruurda, J. P. H., Nieuwenhuijzen, G. A. P., Jeene, P. M., et al. (2022) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221085557 · Cited by 11 · see citing works
Sala, R. J., Ery, J., Cuesta-Peredó, D., Muedra, V., & Rodilla, V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206540 · Cited by 12 · see citing works
Tieng, F. Y. F., Lee, L., & Mutalib, N. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.959705 · Cited by 10 · see citing works
Immune cell infiltrates in peritoneal metastases from colorectal cancer
Sundström, P., Hogg, S., Quiding‐Järbrink, M., & Lindskog, E. B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347900 · Cited by 9 · see citing works
Caruso, M., Stanzione, A., Prinster, A., Pizzuti, L. M., Brunetti, A., Maurea, S., & Mainenti, P. P. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i3.521 · Cited by 9 · see citing works
Zheng, K., Zhu, X., Xu, L., Cao, G., Niu, C., Yan, X., Xu, D., Liu, W., Bao, Q., Wang, L., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1420956 · Cited by 8 · see citing works
Zeng, X., Li, X., Lin, W., Wang, J., Fang, C., Pan, M., Tao, H., & Yang, J. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000002193 · Cited by 8 · see citing works
Mastrantoni, L., Beccia, V., Caira, G., Trovato, G., Calegari, M. A., Basso, M., Salvatore, L., Pozzo, C., Tortora, G., Bria, E., et al. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104106 · Cited by 8 · see citing works
Canseco, L. M., Liu, Y., Lu, C., Lee, K., Chen, H., Hu, W., Tsai, K., Yang, Y., Wang, C., & Hung, C. (2023) · Cancers · doi:10.3390/cancers15184434 · Cited by 8 · see citing works
de Moraes, F. C. A., Rodrigues, A. L. S. D. O., Priantti, J. N., Limachi-Choque, J., & Burbano, R. M. R. (2024) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-024-01128-1 · Cited by 8 · see citing works
Genotype-phenotype associations in colorectal adenocarcinomas and their matched metastases
Chatzopoulos, K., Kotoula, V., Koliou, G.-A., Giannoulatou, E., Papadopoulou, K., Karavasilis, V., Pazarli, E., Pervana, S., Kafiri, G., Tsoulfas, G., et al. (2020) · Human Pathology · doi:10.1016/j.humpath.2020.10.009 · Cited by 8 · see citing works
Kanno, H., Hisaka, T., Fujiyoshi, K., Akiba, J., Hashimoto, K., Fujita, F., & Akagi, Y. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12905-2 · Cited by 8 · see citing works
Cytoreductive surgery and HIPEC in colorectal cancer—did we get hold of the wrong end of the stick?
Yurttas, C., Fisher, O. M., Guiral, D. C., Haen, S. P., Königsrainer, I., Königsrainer, A., Beckert, S., Liauw, W., & Loeffler, M. W. (2020) · memo - Magazine of European Medical Oncology · doi:10.1007/s12254-020-00653-6 · Cited by 8 · see citing works
Zhan, Y., Huang, C., Wang, R., Xiao, X., Xu, X., & Gao, C. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03551-7 · Cited by 7 · see citing works
Kavgacı, G., Akiva, İ., Ozon, Y. H., Berkil, H., Karadayi, H., Dizdar, O., & Yalçın, Ş. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70042 · Cited by 7 · see citing works
Storli, P. E., Dille-Amdam, R. G., Skjærseth, G. H., Gran, M. V., Myklebust, T. Å., Grønbech, J. E., & Bringeland, E. A. (2025) · Acta Oncologica · doi:10.2340/1651-226x.2025.42985 · Cited by 7 · see citing works
Kunitomo, A., Ouchi, A., Komori, K., Kinoshita, T., Sato, Y., Abe, T., Ito, S., Sano, T., & Shimizu, Y. (2023) · Annals of Surgical Oncology · doi:10.1245/s10434-023-14191-y · Cited by 7 · see citing works
Özcan, P., & Düzgün, Ö. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14090916 · Cited by 7 · see citing works
Sirkiä, O., Karjalainen, H., Elomaa, H., Väyrynen, S. A., Tuomisto, A., Sirniö, P., Äijälä, V. K., Tapiainen, V. V., Kastinen, M., Wirta, E., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-4083 · Cited by 7 · see citing works
Self-citationEpidemiological trends in stage IV colorectal cancer
Roberson, J. L., & Maguire, L. H. (2023) · Seminars in Colon and Rectal Surgery · doi:10.1016/j.scrs.2023.100967 · Cited by 7 · see citing works
Mattila, T. T., Patankar, M., Väyrynen, J. P., Klintrup, K., Mäkelä, J. T., Tuomisto, A., Nieminen, P. A., Mäkinen, M. J., & Karttunen, T. J. (2022) · Clinical & Experimental Metastasis · doi:10.1007/s10585-022-10184-5 · Cited by 6 · see citing works
Engstrand, J., Taflin, H. A., Rystedt, J. L., Hemmingsson, O., Urdzik, J., Sandström, P., Björnsson, B., & Hasselgren, K. (2023) · Cancers · doi:10.3390/cancers15051434 · Cited by 6 · see citing works
Management of Oligometastatic Colorectal Cancer
Suydam, C. R., & Schlussel, A. T. (2023) · Surgical Clinics of North America · doi:10.1016/j.suc.2023.11.011 · Cited by 6 · see citing works
Song, Q., Wu, H., Jin, Y., Hou, J., Liu, J., Zhang, X., Hu, W., Sun, G., & Zhang, Z. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1503133 · Cited by 6 · see citing works
Wang, Y., Li, X., Huang, T., Wang, D., He, Y., Wei, M., Chen, Y., Zheng, M., Shi, Y., & Zhang, J. (2023) · World Journal of Surgical Oncology · doi:10.1186/s12957-023-03222-3 · Cited by 6 · see citing works
Second Primary Cancers following Colorectal Cancer in Sicily, Italy
Collatuzzo, G., Ferrante, M., Ippolito, A., Prima, A. A. D., Colarossi, C., Scarpulla, S., Boffetta, P., & Sciacca, S. (2022) · Cancers · doi:10.3390/cancers14215204 · Cited by 5 · see citing works
Fleming, C., Mohan, H. M., O’Leary, D. P., Corrigan, M. A., & Redmond, H. P. (2022) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-022-00813-3 · Cited by 5 · see citing works
Kim, S., Shin, J. K., Park, Y. A., Choi, G., Huh, J. W., Kim, H. C., Heo, J. S., Yun, S. H., Lee, W. Y., Kim, S. T., et al. (2025) · Surgery · doi:10.1016/j.surg.2025.109446 · Cited by 4 · see citing works
Utility of abbreviated MRI in the post-treatment evaluation of rectal cancer
Park, S., Park, H. S., Jang, S., Cho, J., Kim, J. H., Yu, M. H., Jung, S. I., Kim, Y. J., & Hwang, D. (2024) · Acta Radiologica · doi:10.1177/02841851241253936 · Cited by 4 · see citing works
Su, H., Zhang, R., Li, Y., Li, Y., Pei, W., Jie, Z., Liu, Z., Huang, M., Jing, Z., Jiang, Q., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04180-1 · Cited by 4 · see citing works
Prognostic utility of circulating tumor DNA methylation analysis in stage IV colorectal cancer
Momose, H., Sugimoto, K., Irie, T., Nomura, S., Ro, H., Ishiyama, S., Takahashi, M., Pisanic, T. R., & Sakamoto, K. (2024) · Journal of Surgical Oncology · doi:10.1002/jso.27824 · Cited by 4 · see citing works
Management of Metastatic Colorectal Cancer (mCRC): Real-World Recommendations
Parikh, P. M., Bahl, A., Sharma, G., Pramanik, R., Wadhwa, J., Bajpai, P., Jandyal, S., Dubey, A. P., Sarin, A., Dadhich, S. C., et al. (2024) · South Asian Journal of Cancer · doi:10.1055/s-0044-1791689 · Cited by 4 · see citing works
Li, C., Guan, W., Geng, D., & Feng, Y. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09977-z · Cited by 4 · see citing works
Predicting extensive metastasis in postoperative oligometastatic colorectal cancer
Fan, R., Mao, C., Zhang, J., Dai, M., Zhang, R., Wang, X., Dai, J., Li, S., & Zhuang, Z. (2025) · International Journal of Colorectal Disease · doi:10.1007/s00384-025-04841-w · Cited by 4 · see citing works
Shao, B., Yin, Y.-S., Wei, Y.-N., Dong, P., Ning, H.-F., & Wang, G. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1490570 · Cited by 4 · see citing works
Biondo, S., Frago, R., & Kreisler, E. (2024) · Annals of Oncology · doi:10.1016/j.annonc.2024.06.017 · Cited by 4 · see citing works
Tivadar, B., Dumitraşcu, T., & Vasilescu, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082362 · Cited by 3 · see citing works
A systematic review of population‐based studies on metachronous metastases of colorectal cancer
Nyström, K., & Olsson, L. (2024) · World Journal of Surgery · doi:10.1002/wjs.12204 · Cited by 3 · see citing works
Iguchi, K., Shiozawa, M., UCHIYAMA, M., Asari, M., Numata, K., Rino, Y., & Saito, A. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05805-3 · Cited by 3 · see citing works
Sgouros, J., Eliades, A., Papadopoulou, K., Korfiatis, N., Papamichael, D., Fountzilas, E., Tsolaki, E., Achilleos, A., Tsangaras, K., Loizides, C., et al. (2025) · ESMO Gastrointestinal Oncology · doi:10.1016/j.esmogo.2024.100120 · Cited by 3 · see citing works
Li, J., Wang, Z., Huang, J., Ba, Y., Cao, B., Luo, S., Li, W., Bai, C., Song, Z., Xiong, J., et al. (2026) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(25)00267-5 · Cited by 3 · see citing works
Dong, Y., Ding, Y., Yang, X., Song, X.-H., Lei, X.-T., Tang, Y.-N., Zhang, X.-E., Huang, W.-C., Zhang, K., & Jing-song, C. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02537-x · Cited by 3 · see citing works
Zhang, J., Shen, J., Zeng, T., Gao, C., Sheng, B., Li, J., Zeng, W., Shen, J., Shen, C., Wang, J., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1739981 · Cited by 3 · see citing works
Bellio, H., Roussot, N., Bertaut, A., Hervieu, A., Zanetta, S., Tharin, Z., Vincent, J., Bengrine-Lefèvre, L., Hennequin, A., Guion, J.-F., et al. (2025) · Future Oncology · doi:10.1080/14796694.2025.2461446 · Cited by 3 · see citing works
Significance of Th1 and Th2 Cell Densities and Th1/Th2 Cytokine Profiles in Colorectal Cancer
Ojanperä, A., Sirniö, P., Elomaa, H., Äijälä, V. K., Karjalainen, H., Tapiainen, V. V., Kastinen, M., Kehusmaa, A., Rahkola, O., Pohjanen, V., et al. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-25-0767 · Cited by 3 · see citing works
Self-citationComparison of genetic variation between primary colorectal cancer and metastatic peritoneal cancer
Shin, W., Yun, J., Han, K., & Park, D.-G. (2023) · Genes & Genomics · doi:10.1007/s13258-023-01408-3 · Cited by 3 · see citing works
Song, Q., Xu, H., Wu, H., Dong, J., Ji, S., Zhang, X., Zhang, Z., & Hu, W. (2024) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2024e13645 · Cited by 3 · see citing works
Sawano, H., Matsuoka, H., Mizuno, T., Kamiya, T., Chong, Y., Iwama, H., Takahara, T., Hiro, J., Otsuka, K., Ishihara, T., et al. (2024) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2024.07.001 · Cited by 3 · see citing works
Local-Regional Therapy for Oligometastatic Colorectal Cancer
Miller, S. R., & Chang, D. T. (2024) · The Cancer Journal · doi:10.1097/ppo.0000000000000729 · Cited by 3 · see citing works
Chen, M. Z., Austin, K. K. S., Solomon, M. J., Brown, K. G. M., & Steffens, D. (2021) · ANZ Journal of Surgery · doi:10.1111/ans.16294 · Cited by 3 · see citing works
Prognostic value of disease-free interval in colorectal cancer: Is it time?
Birgin, E., Doyon, F., Burkert, J., Téoule, P., Rasbach, E., Rahbari, M., Reißfelder, C., Betzler, A. M., & Rahbari, N. N. (2022) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2022.06.001 · Cited by 3 · see citing works
Long, C., Li, X., Liu, J., Mo, X., Zhong, H., Tang, W., & Yu, J. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70166 · Cited by 2 · see citing works
Dual Role of HNF4α in Colorectal Adenocarcinoma During Carcinogenesis and Metastasis
Kim, J., Kim, K., Heo, J. Y., Choi, M. K., & Yeo, M. (2025) · Cells · doi:10.3390/cells14080599 · Cited by 2 · see citing works
Burlaka, A. A., Rozhkova, V., Mykytyuk, A., Babak, L., Kasap, N. V., & Beznosenko, A. (2025) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjaf476 · Cited by 2 · see citing works
Lei, Y., Yang, Y., Liu, X., Xu, J., Wang, W., Wu, L., & Yan, J. (2025) · World Journal of Surgical Oncology · doi:10.1186/s12957-025-04055-y · Cited by 2 · see citing works
Karjula, T., Elomaa, H., Väyrynen, S. A., Kuopio, T., Ahtiainen, M., Mustonen, O., Puro, I., Niskakangas, A., Mecklin, J., Böhm, J., et al. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03646-0 · Cited by 2 · see citing works
Self-citationEid, M., Trizuljak, J., Taslerová, R., Gryc, M., Vlažný, J., Vilmanova, S., Jelinkova, M., Homolová, A., Tuček, Š., Hlavsa, J., et al. (2024) · Mutagenesis · doi:10.1093/mutage/geae014 · Cited by 2 · see citing works
Mantke, R., Schneider, C., von Ruesten, A., & Hauptmann, M. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001838 · Cited by 2 · see citing works
Jeri-Yabar, A., Vittini-Hernandez, L., Benites‐Meza, J. K., & Prado-Núñez, S. (2024) · Medical Sciences · doi:10.3390/medsci12030047 · Cited by 2 · see citing works
Doğan, H. T., Doğan, M., Kahraman, S., Çanakçı, D., Şendur, M. A. N., Tahtacı, M., & Erdoğan, F. (2025) · Diagnostics · doi:10.3390/diagnostics15020184 · Cited by 2 · see citing works
Lee, K., Su, Y., Wu, K., Cheng, K., Song, L., Tang, C., Chen, H., & Chung, K. (2025) · Annals of Coloproctology · doi:10.3393/ac.2024.00591.0084 · Cited by 2 · see citing works
Luncă, S., Morărașu, Ș., Zaharia, R., Ivanov, A.-A., Clancy, C., O’Brien, L., Ong, W. L., & Dimofte, G. (2025) · Diagnostics · doi:10.3390/diagnostics15111334 · Cited by 2 · see citing works
Xia, X., Du, W., & Gou, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-03684-3 · Cited by 2 · see citing works
Carlsson, G. U., Koumarianou, A. A., Guren, T. K., Haux, J., Katsaounis, P., Kentepozidis, N. K., Pfeiffer, P., Brændengen, M., Mavroudis, D., Taflin, H. A., et al. (2022) · ESMO Open · doi:10.1016/j.esmoop.2022.100589 · Cited by 2 · see citing works
Matsubara, J., Li, Y. F., Koul, S., Mukohyama, J., Salazar, L. E. V., Isobe, T., Qian, D., Clarke, M. F., Sahoo, D., Altman, R. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.633435 · Cited by 2 · see citing works
Popęda, M., Żok, J., Tomasik, B., Duchnowska, R., & Bieńkowski, M. (2025) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04802-9 · Cited by 1 · see citing works
Trehub, Y., Malovanna, A., & Земсков, С. (2025) · Journal of Surgical Oncology · doi:10.1002/jso.28101 · Cited by 1 · see citing works
Pawar, A., Képénékian, V., Omar, A., Bel, N., Villeneuve, L., Drevet, G., Maury, J., Passot, G., & Gléhen, O. (2025) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2025.109650 · Cited by 1 · see citing works
- Authors
- Väyrynen, V, Wirta, E.-V., Seppälä, T., Sihvo, E., Mecklin, J.-P., Vasala, K., & Kellokumpu, I.
- Affiliations
- Departments of Gastrointestinal Surgery , Jyväskylä, Finland
- Tampere University Hospital (FI)
- Johns Hopkins University (US)
- Thoracic Surgery , Jyväskylä, Finland
- University of Jyväskylä (FI)
- Central Finland Health Care District (FI)
- Corresponding author
- Väyrynen, V
- Venue
- BJS Open
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-06-16
- Volume
- 4
- Issue
- 4
- Pages
- 685-692
- ISSN
- 2474-9842 (ISSN-L)
- PMC
- PMC7397359
- OpenAlex
- W3035470988
- Cited by
- 148
- References
- 26
- Citations by year
- 2026: 23 · 2025: 47 · 2024: 34 · 2023: 20 · 2022: 16 · 2021: 6 · 2020: 2
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BJS Open (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Työväentutkimus Vuosikirja (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Keywords
- colorectal cancer, synchronous metastases, metachronous metastasis, metastasectomy, liver metastasis, lung metastasis, overall survival, resection rate, multimodal management, incidence, Central Finland, population-based cancer registry, prognostic factors, quality of life, quality of life after cancer treatment
- MeSH terms
- Aged, Aged, 80 and over, Female, Finland, Humans, Liver Neoplasms, Lung Neoplasms, Male, Middle Aged, Retrospective Studies, Colorectal Neoplasms, Incidence, Survival Rate, Metastasectomy
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