Development of an injectable dopamine-conjugated poly(organophophazene) hydrogel for hemostasis
Abstract
Hemostatic agents are important for minimizing blood loss to improve the patient status during surgery. Most currently used hemostatic agents have limitations such as poor adhesion in the presence of biological fluids, allergic response, and inflammation. We developed a dopamine‐conjugated injectable thermosensitive hydrogel to overcome these limitations through the application of a relatively safe hydrogel for biocompatibility, thermosensitivity to induce tight interactions, and mussel‐induced adhesion. Dopamine as a mussel inspired material was conjugated to an injectable thermosensitive poly(organophosphazene) hydrogel, which showed the potential for application as a hemostatic agent because of its high biocompatibility, injectability, slow mass loss, easy preparation, and hemostatic effect.
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Many mussel-inspired injectable hydrogels have been developed for hemorrhage control.
“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [120]
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Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications
Dou, W., Zeng, X., Zhu, S., Zhu, Y., Liu, H., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169100 · Cited by 52 · see citing works
“During recent decades, many mussel-inspired injectable hydrogels have been developed for hemorrhage control [120,121].”
Background
- Authors
- Kim, Y., Kim, C., Park, M., & Song, S.
- Affiliations
- Korea Institute of Science and Technology (KR)
- Product Development Center CJ Healthcare Icheon 467‐812 Republic of Korea
- Corresponding author
- Song, Soo‐Chang
- Venue
- Bulletin of the Korean Chemical Society
- Publisher
- Wiley
- Published
- 2016-02-22
- Volume
- 37
- Issue
- 3
- Pages
- 372-377
- ISSN
- 0253-2964 (ISSN-L)
- 1229-5949
- OpenAlex
- W2312931985
- Cited by
- 13
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bulletin of the Korean Chemical Society (publishedVersion)
- Funders
- Korea Institute of Science and Technology
- National Research Foundation of Korea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- hemostatic agents, dopamine conjugation, thermosensitive hydrogel, injectable hydrogel, mussel-inspired adhesion, blood loss reduction, biocompatibility, surgical hemostasis
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