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Cited by 61Neuroscience and Neural EngineeringVagus Nerve Stimulation ResearchPain Management and Treatment

Neuromodulation of the peripheral nervous system: Bioelectronic technology and prospective developments

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Song, Hayoung, Kim, Moohyun, Kim, Enji, Lee, Jakyoung, Jeong, Inhea, Lim, Kyeonghee, Ryu, Seoung Young, Oh, Myoungjae +2 more·2024·BMEMat
DOI 10.1002/bmm2.12048
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Abstract

The peripheral nervous system (PNS) is a fascinatingly complex and crucial component of the human body, responsible for transmitting vital signals throughout the body's intricate network of nerves. Its efficient functioning is paramount to our health, with any dysfunction often resulting in serious medical conditions, including motor disorders, neurological diseases, and psychiatric disorders. Recent strides in science and technology have made neuromodulation of the PNS a promising avenue for addressing these health issues. Neuromodulation involves modifying nerve activity using a range of techniques, such as electrical, chemical, optical, and mechanical stimulation. Bioelectronics plays a critical role in this effort, allowing for precise, controlled, and sustained stimulation of the PNS. This paper provides an overview of the PNS, discusses the current state of neuromodulation devices, and presents emerging trends in the field, including advances in wireless power transfer and materials, that are shaping the future of neuromodulation.

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  • Optical stimulators have higher spatial specificity than their electrical counterparts in central and peripheral targets.

    “This has led to the development of optical stimulators (Fig. 3(b)) with higher spatial specificity than their electrical counterparts in the central and peripheral targets [108].”

    From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [108]

    Section 3.3 describes optical neuromodulation as a high-spatiotemporal-precision alternative to conventional techniques for targeting the peripheral nervous system. It does not establish higher spatial specificity than electrical stimulation in both central and peripheral targets. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Mechanical modes of neurostimulation enable non-invasive technologies such as ultrasound and magnetic forces by operating on the basis of mechanotransduction to convert mechanical stimuli into electrophysiological signals through compression, expansion, bending and tension.

    “Mechanical modes of neurostimulation enable non-invasive technologies such as ultrasound and magnetic forces by operating on the basis of mechanotransduction to convert mechanical stimuli into electrophysiological signals through compression, expansion, bending and tension [108].”

    From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [108]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

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References 204 · Cited by 61

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Research works printed but not linked: 89

  1. Y. Cho, J. Park, C. Lee, S. Lee, Bioelectron. Med. 2020, 6, 23.
  2. Y. H. Jung, J. U. Kim, J. S. Lee, J. H. Shin, W. Jung, J. Ok, T. Kim, Adv. Mater. 2020, 32, 1907478.
  3. W. Jung, C. Heo, J. U. Kim, C. Jeong, H. Ryu, B. Park, M. Suh, T. Kim, J. Micromech. Microeng. 2021, 31, 034002.
  4. Y. Chen, Y. Zhang, Z. Liang, Y. Cao, Z. Han, X. Feng, npj Flexible Electron. 2020, 4, 2.
  5. A. D. Kaye, S. Ridgell, E. S. Alpaugh, A. Mouhaffel, A. J. Kaye, E. M. Cornett, A. A. Chami, R. Shah, B. M. Dixon, O. Viswanath, I. Urits, A. N. Edinoff, R. D. Urman, Pain Ther. 2021, 10, 961.
  6. O. Karatum, M.-J. Gwak, J. Hyun, A. Onal, G. R. Koirala, T. Kim, S. Nizamoglu, Chem. Soc. Rev. 2023, 52, 3326.
  7. B. Park, J. H. Shin, J. Ok, S. Park, W. Jung, C. Jeong, S. Choy, Y. J. Jo, T. Kim, Science 2022, 376, 624.
  8. J. K. Mai, G. Paxinos, The Human Nervous System, Academic Press, 2012.
  9. M. Catala, N. Kubis, Handb. Clin. Neurol. 2013, 115, 29.
  10. V. E. Abraira, D. D. Ginty, Neuron 2013, 79, 618.
  11. D. H. Barron, B. H. C. Matthews, J. Physiol. 1938, 92, 276.
  12. H. Kuhlenbeck, The Central Nervous System of Vertebrates, Vol. 5/I: Derivatives of the Prosencephalon: Diencephalon and Telencephalon, S. Karger AG, 1977.
  13. L. K. McCorry, Am. J. Pharm. Educ. 2007, 71, 78.
  14. H. Yuan, S. D. Silberstein, Headache J. Head, Face Pain 2016, 56, 71.
  15. R. L. Johnson, C. G. Wilson, J. Inflamm. Res. 2018, 11, 203.
  16. T. R. Henry, Neurology 2002, 59, S3.
  17. S. C. Schachter, C. B. Saper, Epilepsia 1998, 39, 677.
  18. E. Ben-Menachem, Lancet Neurol. 2002, 1, 477.
  19. C. D. Binnie, Seizure 2000, 9, 161.
  20. H. A. Sackeim, A. J. Rush, M. S. George, L. B. Marangell, M. M. Husain, Z. Nahas, C. R. Johnson, S. Seidman, C. Giller, S. Haines, R. K. Simpson, R. R. Goodman, Neuro- psychopharmacology 2001, 25, 713.
  21. G. Mancia, P. Bousquet, J. L. Elghozi, M. Esler, G. Grassi, S. Julius, J. Reid, P. A. Van Zwieten, J. Hypertens. 2007, 25, 909.
  22. G. Glick, E. Braunwald, R. M. Lewis, Circ. Res. 1965, 16, 363.
  23. S. D. Kreibig, Biol. Psychol. 2010, 84, 394.
  24. M. Rao, M. D. Gershon, Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 517.
  25. A. D. Mickle, S. M. Won, K. N. Noh, J. Yoon, K. W. Mea- cham, Y. Xue, L. A. McIlvried, B. A. Copits, V. K. Samineni, K. E. Crawford, D. H. Kim, P. Srivastava, B. H. Kim, S. Min, Y. Shiuan, Y. Yun, M. A. Payne, J. Zhang, H. Jang, Y. Li, H. H. Lai, Y. Huang, S.-I. Park, R. W. Gereau, J. A. Rogers, Nature 2019, 565, 361.
  26. N. M. Kapadia, V. Zivanovic, J. Furlan, B. C. Craven, C. McGillivray, M. R. Popovic, Artif. Organs 2011, 35, 212.
  27. T. A. Thrasher, V. Zivanovic, W. McIlroy, M. R. Popovic, Neurorehabil. Neural Repair 2008, 22, 706.
  28. A. Prochazka, in Compr. Physiol, John Wiley & Sons, Ltd 2018, p. 127.
  29. P. H. Peckham, J. S. Knutson, Annu. Rev. Biomed. Eng. 2005, 7, 327.
  30. A. Bastos Conforto, K. Nocelo Ferreiro, C. Tomasi, R. L. dos Santos, V. Loureiro Moreira, S. K. Nagahashi Marie, S. C. Baltieri, M. Scaff, L. G. Cohen, Neurorehabil. Neural Repair 2010, 24, 263.
  31. P. Celnik, F. Hummel, M. Harris-Love, R. Wolk, L. G. Cohen, Arch. Phys. Med. Rehabil. 2007, 88, 1369.
  32. A. B. Conforto, A. Kaelin-Lang, L. G. Cohen, Ann. Neurol. 2002, 51, 122.
  33. I. B. M. Koesler, M. Dafotakis, M. Ameli, G. R. Fink, D. A. Nowak, J. Neurol., Neurosurg. Psychiatry 2009, 80, 614.
  34. H. E. Lee, J. H. Park, D. Jang, J. H. Shin, T. H. Im, J. H. Lee, S. K. Hong, H. S. Wang, M. S. Kwak, M. Peddigari, C. K. Jeong, Y. Min, C. H. Park, J.-J. Choi, J. Ryu, W.-H. Yoon, D. Kim, K. J. Lee, G.-T. Hwang, Nano Energy 2020, 75, 104951.
  35. D. Ristić, J. Ellrich, Neuromodulation Technol. Neural Interf. 2014, 17, 686.
  36. S. Helm, N. Shirsat, A. Calodney, A. Abd-Elsayed, D. Kloth, A. Soin, S. Shah, A. Trescot, Pain Ther. 2021, 10, 985.
  37. C. A. Gilmore, B. M. Ilfeld, J. M. Rosenow, S. Li, M. J. Desai, C. W. Hunter, R. L. Rauck, A. Nader, J. Mak, S. P. Cohen, N. D. Crosby, J. W. Boggs, Reg. Anesth. Pain Med. 2020, 45, 44.
  38. R. Haque, C. J. Winfree, Neurosurg. Focus 2006, 21, 1.
  39. K. V. Slavin, K. J. Burchiel, Contemp. Neurosurg. 1999, 21, 1.
  40. E. Papuć, K. Rejdak, Ann. Agric. Environ. Med. 2013, 20, 14.
  41. H. Zeng, K. Pacheco-Barrios, Y. Cao, Y. Li, J. Zhang, C. Yang, F. Fregni, Sci. Rep. 2020, 10, 19184.
  42. A. E. Yakovlev, A. T. Peterson, Neuromodulation Technol. Neural Interf. 2007, 10, 373.
  43. S. Meoni, E. Moro, Dev. Med. Child Neurol. 2020, 62, 6.
  44. M. Vidailhet, J. Yelnik, C. Lagrange, V. Fraix, D. Grabli, S. Thobois, P. Burbaud, M.-L. Welter, J. Xie-Brustolin, M.-C. C. Braga, C. Ardouin, V. Czernecki, H. Klinger, S. Chabardes, E. Seigneuret, P. Mertens, E. Cuny, S. Navarro, P. Cornu, A.- L. Benabid, J.-F. LeBas, D. Dormont, M. Hermier, K. Dujardin, S. Blond, P. Krystkowiak, A. Destée, E. Bardinet, Y. Agid, P. Krack, E. Broussolle, P. Pollak, Lancet Neurol. 2009, 8, 709.
  45. T. D. Sanger, Dev. Med. Child Neurol. 2020, 62, 28.
  46. Q. K. Lippmann, E. J. Geller, Neuromodulation 2014, 17, 396.
  47. S. Hastings, H. Zhong, R. Feinstein, G. Zelczer, C. Mitrovich, P. Gad, V. R. Edgerton, Nat. Commun. 2022, 13, 5660.
  48. D. R. Dolbow, A. S. Gorgey, D. X. Cifu, J. R. Moore, D. R. Gater, Spinal Cord 2012, 50, 170.
  49. J. W. van der Scheer, V. L. Goosey-Tolfrey, S. E. Valentino, G. M. Davis, C. H. Ho, J. Neuroengineering Rehabil. 2021, 18, 99.
  50. J. Crosbie, A. I. P. Tanhoffer, C. Fornusek, Spinal Cord 2014, 52, 251.
  51. H. Zhang, Y. Liu, K. Zhou, W. Wei, Y. Liu, Front. Neurosci. 2021, 15, 749465.
  52. D. M. Thompson, A. N. Koppes, J. G. Hardy, C. E. Schmidt, Annu. Rev. Biomed. Eng. 2014, 16, 397.
  53. C. E. Bouton, A. Shaikhouni, N. V. Annetta, M. A. Bock- brader, D. A. Friedenberg, D. M. Nielson, G. Sharma, P. B. Sederberg, B. C. Glenn, W. J. Mysiw, A. G. Morgan, M. Deogaonkar, A. R. Rezai, Nature 2016, 533, 247.
  54. P. Dasgupta, C. Haslam, R. Goodwin, C. j. Fowler, Br. J. Urol. 1997, 80, 234.
  55. S. C. Kabay, M. Yucel, S. Kabay, Urology 2008, 71, 641.
  56. C. Gobbi, G. Digesu, V. Khullar, S. El Neil, G. Caccia, C. Zecca, Mult. Scler. J. 2011, 17, 1514.
  57. M. S. Rahnama'i, Mult. Scler. J. 2020, 26, 1274.
  58. M. S. Rahnama'i, G. A. V. Koeveringe, P. E. V. Kerrebroeck, Nephrourol. Mon. 2013, 5, 934.
  59. M. J. McGee, C. L. Amundsen, W. M. Grill, J. Spinal Cord Med. 2015, 38, 135.
  60. Y. W. Kwon, Y. S. Jun, Y.-G. Park, J. Jang, J.-U. Park, Nano Res. 2021, 14, 3070.
  61. Y. Zhao, B. Wang, J. Tan, H. Yin, R. Huang, J. Zhu, S. Lin, Y. Zhou, D. Jelinek, Z. Sun, K. Youssef, L. Voisin, A. Horrillo, K. Zhang, B. M. Wu, H. A. Coller, D. C. Lu, Q. Pei, S. Emami- nejad, Science 2022, 378, 1222.
  62. B. T. Wall, M. L. Dirks, L. B. Verdijk, T. Snijders, D. Hansen, P. Vranckx, N. A. Burd, P. Dendale, L. J. C. van Loon, Am. J. Physiol.: Endocrinol. Metab. 2012, 303, E614.
  63. M. L. Dirks, B. B. L. Groen, R. Franssen, J. van Kranenburg, L. J. C. van Loon, J. Appl. Physiol. 2017, 122, 20.
  64. M. L. Dirks, B. T. Wall, T. Snijders, C. L. P. Ottenbros, L. B. Verdijk, L. J. C. van Loon, Acta Physiol. 2014, 210, 628.
  65. M. Milosevic, C. Marquez-Chin, K. Masani, M. Hirata, T. Nomura, M. R. Popovic, K. Nakazawa, Biomed. Eng. Online 2020, 19, 81.
  66. N. V. Annetta, J. Friend, A. Schimmoeller, V. S. Buck, D. A. Friedenberg, C. E. Bouton, M. A. Bockbrader, P. D. Ganzer, S. C. Colachis, M. Zhang, W. J. Mysiw, A. R. Rezai, G. Sharma, IEEE Trans. Biomed. Eng. 2019, 66, 910.
  67. X. Bao, Y. Zhou, Y. Wang, J. Zhang, X. Lü, Z. Wang, PLoS One 2018, 13, e0190936.
  68. J. Ciancibello, K. King, M. A. Meghrazi, S. Padmanaban, T. Levy, R. Ramdeo, M. Straka, C. Bouton, Bioelectron. Med. 2019, 5, 19.
  69. A. F. Kolen, R. N. J. de Nijs, F. M. Wagemakers, A. J. L. Meier, M. I. Johnson, Pain 2012, 153, 373.
  70. A. M. Cobo, C. E. Larson, K. Scholten, J. A. Miranda, S. Elyahoodayan, D. Song, V. Pikov, E. Meng, J. Micro- electromech. Syst. 2019, 28, 36.
  71. A. Sadeqi, G. Kiaee, W. Zeng, H. Rezaei Nejad, S. Sonkusale, Sci. Rep. 2022, 12, 1853.
  72. S. F. Lahiji, M. Dangol, H. Jung, Sci. Rep. 2015, 5, 7914.
  73. A. D. Izzo, J. T. Walsh, H. Ralph, J. Webb, M. Bendett, J. Wells, C.-P. Richter, Biophys. J. 2008, 94, 3159.
  74. C.-P. Richter, R. Bayon, A. D. Izzo, M. Otting, E. Suh, S. Goyal, J. Hotaling, J. T. Walsh, Hear. Res. 2008, 242, 42.
  75. F. Michoud, L. Sottas, L. E. Browne, L. Asboth, A. Latre- moliere, M. Sakuma, G. Courtine, C. J. Woolf, S. P. Lacour, J. Neural. Eng. 2018, 15, 015002.
  76. V. K. Samineni, A. D. Mickle, J. Yoon, J. G. Grajales-Reyes, M. Y. Pullen, K. E. Crawford, K. N. Noh, G. B. Gereau, S. K. Vogt, H. H. Lai, J. A. Rogers, R. W. Gereau, Sci. Rep. 2017, 7, 15865.
  77. M. E. Downs, S. A. Lee, G. Yang, S. Kim, Q. Wang, E. E. Konofagou, Phys. Med. Biol. 2018, 63, 035011.
  78. B. U. Hoffman, Y. Baba, S. A. Lee, C.-K. Tong, E. E. Kono- fagou, E. A. Lumpkin, Proc. Natl. Acad. Sci. U. S. A. 2022, 119, e2115821119.
  79. E. A. Lysenko, O. L. Vinogradova, D. V. Popov, J. Evol. Bio- chem. Physiol. 2021, 57, 862.
  80. K. Takeda, G. Tanino, H. Miyasaka, Med. Devices: Evidence Res. 2017, 10, 207.
  81. J. Petrofsky, M. Laymon, M. Prowse, S. Gunda, J. Batt, J. Med. Eng. Technol. 2009, 33, 170.
  82. Y. Laufer, J. D. Ries, P. M. Leininger, G. Alon, Phys. Ther. 2001, 81, 1307.
  83. M. Papaiordanidou, S. Takamatsu, S. Rezaei-Mazinani, T. Lonjaret, A. Martin, E. Ismailova, Adv. Healthcare Mater. 2016, 5, 2001.
  84. M. I. Johnson, Medicina (Kaunas). 2021, 57, 378.
  85. Y. Merhi, P. F. Betancur, T. S. Ripolles, C. Suetta, M. R. Brage-Andersen, S. K. Hansen, A. Frydenlund, J. V. Nygaard, P. H. Mikkelsen, P. P. Boix, S. Agarwala, Nanoscale 2023, 15, 5337.
  86. H. Zhou, Y. Lu, W. Chen, Z. Wu, H. Zou, L. Krundel, G. Li, Sensors 2015, 15, 17241.
  87. L. Ni, Z. Yao, Y. Zhao, T. Zhang, J. Wang, S. Li, Z. Chen, Front. Neurol. 2023, 14, 1081458.
  88. M. Moayedi, K. D. Davis, J. Neurophysiol. 2013, 109, 5.
  89. M. I. Johnson, G. Jones, C. A. Paley, P. G. Wittkopf, BMJ Open 2019, 9, e029999.

Authors
Song, H., Kim, M., Kim, E., Lee, J., Jeong, I., Lim, K., Ryu, S. Y., Oh, M., Kim, Y., & Park, J.
Affiliations
Yonsei University (KR)
Corresponding author
Park, Jang‐Ung
ORCID
Venue
BMEMat
Publisher
Wiley
Published
2023-09-26
Volume
2
Issue
1
ISSN
  • 2751-7446 (ISSN-L)
  • 2751-7438
DOI
10.1002/bmm2.12048
OpenAlex
W4387043471
Cited by
61
References
204
Citations by year
2026: 25 · 2025: 28 · 2024: 8
FWCI
7.38
Type
journal article
Language
en
Open access
Licence
Locations
  • BMEMat (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Institute for Basic Science (IBS‐R026‐D1)
  • Korea Medical Device Development Fund (RMS 2022‐11‐1209/KMDF RS‐2022‐00141392)
  • National Research Foundation of Korea (2020R1A5A1019131, 2021M3D1A2049914, 2022R1A5A6000846, 2023R1A2C2006257)
  • Korea Evaluation Institute of Industrial Technology (20013621)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
peripheral nervous system, neuromodulation, bioelectronics, peripheral nerve stimulation, neuromodulation devices, wireless power transfer, bioelectronic materials, neurological disorders, motor disorders, mental illness

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