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Cited by 48Biosensors and Analytical DetectionAdvanced biosensing and bioanalysis techniquesAdvanced Biosensing Techniques and Applications

The DOI matches its Crossref record.

Advances in nanoprobes‐based immunoassays

Open access
Zhang, Lusi, Huang, Bin, Jin, Jing, Li, Yan, Gu, Ning·2024·BMEMat
DOI 10.1002/bmm2.12057
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Abstract

Immunoassay is a powerful technique that uses highly specific antigen‐antibody interactions to detect biochemical targets such as proteins and toxins. As a diagnostic tool, immunoassay is employed in the screening, diagnosis, and prognosis of diseases, which are crucial for the grasp and control of patient conditions in clinical practice. With the rapid development of nanotechnology, immunoassays based on nanoprobes have attracted more and more attention due to the advantages of high sensitivity, specificity, stability, and versatility. These nanoprobes are nanoscale particles that can act as signal carriers or targeting agents for immunoassays. In this paper, we review the recent advances in various types of nanoprobes for immunoassays, such as colloidal gold, quantum dots, magnetic nanoparticles, nanozymes, aggregation‐induced emission, and up‐conversion nanoparticles. The effect of the nanoprobe construction and synthesis methods on their detection performance deserves to be studied in depth. We also compare their detection ranges and limits in different immunoassay methods, such as lateral flow immunoassays, fluorescent immunoassays, and surface‐enhanced Raman scattering immunoassays. Moreover, we discuss the benefits and challenges of nanoprobes in immunoassays and provide insights into their future development. This study aims to offer a comprehensive and critical perspective on the role of nanoprobes in the field of immunoassays.

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  • Application of nanomaterials is hindered by non-specific cytotoxicity and suboptimal biocompatibility, which can trigger adverse immune responses.

    “Non-specific cytotoxicity, arising from unintended interactions with non-target cells, and suboptimal biocompatibility, which can trigger adverse immune responses, are among the primary concerns [53, 228].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [228]

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Metadata

Authors
Zhang, L., Huang, B., Jin, J., Li, Y., & Gu, N.
Affiliations
  • Southeast University (CN)
  • Nanjing Medical University (CN)
  • Nanjing RealMind Biotech Co., Ltd. Nanjing Economic and Technological Development Zone Nanjing China
Corresponding author
  • Huang, Bin
  • Jin, Jing
  • Gu, Ning
ORCID
Venue
BMEMat
Publisher
Wiley
Published
2023-10-14
Volume
2
Issue
1
ISSN
  • 2751-7446 (ISSN-L)
  • 2751-7438
DOI
10.1002/bmm2.12057
OpenAlex
W4387639007
Cited by
48
References
0
Citations by year
2026: 24 · 2025: 14 · 2024: 10
FWCI
3.79
Type
journal article
Language
en
Open access
Licence
Locations
  • BMEMat (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (51832001, 61821002)
  • Natural Science Foundation of Jiangsu Province (BK20222002)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
Keywords
nanoprobes, immunoassay, colloidal gold nanoparticles, quantum dots, magnetic nanoparticles, nanozymes, aggregation-induced emission, upconversion nanoparticles, lateral flow immunoassay, fluorescence immunoassay, surface-enhanced Raman scattering, detection sensitivity

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