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Cited by 3Tuberculosis Research and EpidemiologyMedication Adherence and ComplianceHIV/AIDS Research and Interventions

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Improving Treatment Adherence in Youths with Multidrug-Resistant Tuberculosis with Psychosocial Intervention

Open access
Dhumal, Gauri, Nevrekar, Neetal, Gupte, Nikhil, Shrisunder, Rechel, Kulkarni, Prashant, Sarpotdar, Sayali, PM, Akhil, Hosmani, Abhijit, Lokhande, Rahul, Gupta, Amita, Suryavanshi, Nishi·2025·Brain and Behavior
DOI 10.1002/brb3.70665PMC PMC12321948
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Abstract

INTRODUCTION: Multidrug-resistant tuberculosis (MDR-TB) deeply impacts the well-being of adolescents and young adults (AYA), resulting in poor treatment adherence. Identifying psychosocial challenges and preferred interventions is essential to enhance treatment adherence and outcomes in this unique group. METHODS: This was a mixed-method study where participants aged between 15 and 24 years, diagnosed with MDR-TB, were recruited for in-depth interviews and a semi-structured questionnaire. RESULTS: The individual-level psychosocial challenges included mental stress, suicidal ideation, reluctance to continue medication, perceived and experienced stigma, and socio-economic burdens. Health system-related challenges encompassed delayed diagnosis, drug stockouts, and negative experiences with Health Care Providers (HCPs). Among 75 participants, the median age was 20.5 years, with 57% (n = 41) females, 85% (n = 62) single, and a median treatment duration of 8 months at the interview. Seventy-two percent (n = 54) of the participants reported psychological issues such as irritation, loneliness, anxiety, sleep disorder, suicidal ideation, and stigma. Individual-level interventions were preferred by 61% (n = 46) of participants, including social media, deep breathing, and exercise training. CONCLUSIONS: To enhance results in MDR-TB, it is crucial to develop and assess personalized psychosocial interventions with tailored adjustments to tackle the psychosocial obstacles encountered by adolescents and young adults with MDR-TB.

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FIGURE 1 Challenges faced during the treatment. Psychological challenges include anger/irritation, stress, sleep problems and low feeling; Affected daily activities include disturbances in the sleep‐wake cycle and challenges in managing routine activities; Effects on work/studies include unable to concentrate on work, memory issues, lost self‐desire to study, scored low grades, school/college dropouts; Economic challenges include challenging to meet living and the travel cost. Health system‐related challenges include delay in diagnosis and delay in treatment initiation.
FIGURE 1 Challenges faced during the treatment. Psychological challenges include anger/irritation, stress, sleep problems and low feeling; Affected daily activities include disturbances in the sleep‐wake cycle and challenges in managing routine activities; Effects on work/studies include unable to concentrate on work, memory issues, lost self‐desire to study, scored low grades, school/college dropouts; Economic challenges include challenging to meet living and the travel cost. Health system‐related challenges include delay in diagnosis and delay in treatment initiation.CC BY · PubMed Central
FIGURE 2 Psychosocial intervention preferences. Individual interventions include social media, deep breathing techniques, exercise training, Individual counseling, helpline support for health, counseling booklet, emotion‐focused strategies; Group interventions include peer group support, Through social activities, Health insurance schemes, Workplace oriented activites, stigma reduction intervention.
FIGURE 2 Psychosocial intervention preferences. Individual interventions include social media, deep breathing techniques, exercise training, Individual counseling, helpline support for health, counseling booklet, emotion‐focused strategies; Group interventions include peer group support, Through social activities, Health insurance schemes, Workplace oriented activites, stigma reduction intervention.CC BY · PubMed Central

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Research works printed but not linked: 2

  1. American Psychiatric Association, 2013, DSM‐5‐TR Self‐Rated Level 1 Cross‐Cutting Symptom Measure—Adult, Child Age11–17
  2. National Statistical Office, 2022, Youth in India 2022

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Authors
Dhumal, G., Nevrekar, N., Gupte, N., Shrisunder, R., Kulkarni, P., Sarpotdar, S., PM, A., Hosmani, A., Lokhande, R., Gupta, A., & Suryavanshi, N.
Affiliations
  • Johns Hopkins University (US)
  • Aundh Chest Hospital Pune India
  • B. J. Medical College & Sassoon Hospital (IN)
Corresponding author
Dhumal, Gauri
ORCID
Venue
Brain and Behavior
Publisher
Wiley
Published
2025-08
Volume
15
Issue
8
Pages
e70665-e70665
ISSN
  • 2157-9032 (ISSN-L)
  • 2162-3279
DOI
10.1002/brb3.70665
PMC
PMC12321948
OpenAlex
W4412998198
Cited by
3
References
32
Citations by year
2026: 3
FWCI
2.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain and Behavior (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
United States Agency for International Development
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
multidrug-resistant tuberculosis, adolescents and young adults, medication adherence, psychosocial interventions, stigma, suicidal ideation, psychological stress, social support, drug stock-outs, health professionals' experiences, personalized interventions, social media, exercise training
MeSH terms
Psychosocial Intervention, Adolescent, Adult, Female, Humans, Male, Tuberculosis, Multidrug-Resistant, Medication Adherence, Young Adult, Social Stigma, Suicidal Ideation

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