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Antibacterial Mechanism of Curcumin: A Review
Abstract
Curcumin is a plant‐derived polyphenolic active substance with broad‐spectrum antibacterial properties. Curcumin blocks bacterial growth owing to its structural characteristics and the generation of antioxidation products. Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. As a photosensitizer, curcumin acts under blue light irradiation to induce phototoxicity and inhibit bacterial growth. Moreover, it can exert a synergistic antibacterial effect with other antibacterial substances. In this review, we summarize the research progress on the antibacterial mechanism of curcumin based on five targeting structures and two modes of action. Our discussion provides a theoretical basis and technical foundation for the development and application of natural antibacterial agents.
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Aggarwal, B. B., & Sung, B. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.11.002 · Cited by 1,140
Initial Validation of an Exercise “Vital Sign” in Electronic Medical Records
COLEMAN, K. J., NGOR, E., REYNOLDS, K., QUINN, V. P., KOEBNICK, C., YOUNG, D. R., STERNFELD, B., & SALLIS, R. E. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182630ec1 · Cited by 376
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Tavakoli, M., Labbaf, S., Mirhaj, M., Salehi, S., Seifalian, A. M., & Firuzeh, M. (2023) · Journal of Applied Polymer Science · doi:10.1002/app.53910 · Cited by 74
Saifi, S., Ashraf, A., Hasan, G. M., Shamsi, A., & Hassan, M. I. (2024) · Fitoterapia · doi:10.1016/j.fitote.2023.105811 · Cited by 25
Metadata
- Authors
- Zheng, D., Huang, C., Huang, H., Zhao, Y., Khan, M. R. U., Zhao, H., & Huang, L.
- Venue
- Chemistry & Biodiversity
- Publisher
- Wiley
- Published
- 2020-07-27
- Volume
- 17
- Issue
- 8
- Pages
- e2000171-e2000171
- ISSN
- 1612-1872 (ISSN-L)
- 1612-1880
- OpenAlex
- W3034741772
- Cited by
- 534
- References
- 2
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zheng, D., Huang, C., Huang, H., Zhao, Y., Khan, M. R. U., Zhao, H., & Huang, L. (2020). Antibacterial Mechanism of Curcumin: A Review. Chemistry & Biodiversity. https://doi.org/10.1002/cbdv.202000171
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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