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Cited by 65Exercise and Physiological ResponsesCardiovascular and exercise physiologyImmune Response and Inflammation

Acute exercise stimulates macrophage function: possible role of NF‐κB pathways

Silveira, Elza M. S., Rodrigues, Mariana F., Krause, Maurício S., Vianna, Damiana R., Almeida, Bibiana S., Rossato, Juliane S., Oliveira, Lino P., Curi, Rui +1 more·2007·Cell Biochemistry and Function
DOI 10.1002/cbf.1365
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Abstract

Moderate physical activity when performed on a regular basis presents a number of benefits to the whole organism, especially regarding immune system function, such as augmenting resistance to infections and to cancer growth. Although glutamine production by active muscle cells as well as neuroendocrine alterations mediated by the chronic adaptation to exercise may play a role, the entire mechanism by which exercise makes the immune system aware of challenges remains mostly uncovered. This is particularly true for the effects of an acute exercise session on immune function. In this work, circulating monocytes/macrophages from sedentary rats submitted to an acute (1 h) swimming session were tested for the ability of phagocytosing zymosan particles, phorbol myristate acetate (PMA)-induced hydrogen peroxide production, nitric oxide (NO) release (assessed by nitrate and nitrite production) and the expression of NO synthases (NOS-1, NOS-2 and NOS-3). The results showed that an exercise bout induced a 2.4-fold rise in macrophage phagocytic capacity (p = 0.0041), a 9.6-fold elevation in PMA-induced hydrogen peroxide release into the incubation media (1-h, p = 0.0022) and a 95.5%-augmentation in nitrite basal production (1-h incubation; p = 0.0220), which was associated with a marked expression of NOS-2 (the inducible NOS isoform; p = 0.0319), but not in other NOS gene products. Although NOS-2 expression is nuclear factor-kappaB (NF-kappaB)-dependent, no systemic oxidative stress was found, as inferred from the data of plasma TBARS and glutathione disulphide (GSSG) to glutathione (GSH) ratio in circulating blood erythrocytes which remained constant after the acute exercise. Also, no stressful situation seemed to be faced by monocytes/macrophages, since the expression of the 70-kDa heat shock protein (HSP70) remained unchanged. We conclude that NF-kappaB-dependent induction of NOS-2 and macrophage activation must be related to local factor(s) produced in the surroundings of monocytes/macrophages.

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Authors
Silveira, E. M. S., Rodrigues, M. F., Krause, M. S., Vianna, D. R., Almeida, B. S., Rossato, J. S., Oliveira, L. P., Curi, R., & de Bittencourt, P. I. H.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Universidade de São Paulo (BR)
ORCID
Venue
Cell Biochemistry and Function
Publisher
Wiley
Published
2006-08-14
Volume
25
Issue
1
Pages
63-73
ISSN
  • 0263-6484 (ISSN-L)
  • 1099-0844
DOI
10.1002/cbf.1365
OpenAlex
W1990529662
Cited by
65
References
37
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 9
FWCI
2.63
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cell Biochemistry and Function (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
acute exercise, macrophage activation, NF-κB signaling, inducible nitric oxide synthase, nitric oxide production, hydrogen peroxide, phagocytosis, zymosan, monocytes, oxidative stress, HSP70, swimming training, immune function, sedentary rats
MeSH terms
Animals, Cells, Cultured, Heat-Shock Proteins, Hydrogen Peroxide, Inflammation, Macrophages, Male, Nitrates, Nitric Oxide, Nitrites, Phagocytes, Physical Conditioning, Animal, Time Factors, Signal Transduction, NF-kappa B, Rats, Wistar, Oxidative Stress, Nitric Oxide Synthase, Rats

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