The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases
Abstract
Getting down to specifics: Key amino acid residues were found to correlate with ketoreductase domain stereospecificity in modular polyketide synthases. These residues may allow alcohol stereochemistry (see scheme; ACP, acyl carrier protein) in polyketides to be predicted from ketoreductase sequences. The results also suggest that polyketide synthase dehydratase domains have a preference for 3hydroxyacyl substrates with the same alcohol stereochemistry as the (3R)-hydroxyacyl chains used by dehydratases in fatty acid synthases.
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Cites
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Staunton, J., & Weissman, K. J. (2001) · Natural Product Reports · doi:10.1039/a909079g · Cited by 1,641
Modular Organization of Genes Required for Complex Polyketide Biosynthesis
Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., & Katz, L. (1991) · Science · doi:10.1126/science.2024119 · Cited by 898
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Tolerance and Specificity of Polyketide Synthases
Khosla, C., Gokhale, R. S., Jacobsen, J. R., & Cane, D. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.219 · Cited by 338
A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases
Reid, R., Piagentini, M., Rodriguez, E., Ashley, G., Viswanathan, N., Carney, J., Santi, D. V., Hutchinson, C. R., & McDaniel, R. (2003) · Biochemistry · doi:10.1021/bi0268706 · Cited by 310
Caffrey, P., Lynch, S., Flood, E., Finnan, S., & Oliynyk, M. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00046-1 · Cited by 250
Self-citationStereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
Marsden, A. F. A., Caffrey, P., Aparicio, J. F., Loughran, M. S., Staunton, J., & Leadlay, P. F. (1994) · Science · doi:10.1126/science.8278811 · Cited by 165
Self-citationEvidence for a double-helical structure for modular polyketide synthases
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Cited by
The Biosynthetic Logic of Polyketide Diversity
Hertweck, C. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200806121 · Cited by 1,346
Edwards, D. J., Marquez, B. L., Nogle, L. M., McPhail, K., Goeger, D. E., Roberts, M. A., & Gerwick, W. H. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.03.030 · Cited by 506
Combinatorial biosynthesis of reduced polyketides
Weissman, K. J., & Leadlay, P. F. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1287 · Cited by 466
Bachmann, B. O., & Ravel, J. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(09)04808-3 · Cited by 370
The structures of type I polyketide synthases
Keatinge-Clay, A. T. (2012) · Natural Product Reports · doi:10.1039/c2np20019h · Cited by 344
Metadata
- Authors
- Caffrey, P.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2003-06-27
- Volume
- 4
- Issue
- 7
- Pages
- 654-657
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W2097118224
- Cited by
- 368
- References
- 11
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases. https://app.cochat.ai/papers/10.1002/cbic.200300581
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- Caffrey, P. (2003). Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases. ChemBioChem. https://doi.org/10.1002/cbic.200300581
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
