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Cited by 486

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The Polar Hydrophobicity of Fluorinated Compounds

Biffinger, Justin C., Kim, Hong Woo, DiMagno, Stephen G.·2004·ChemBioChem
DOI 10.1002/cbic.200300910
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Abstract

Fluorine's peculiar property: The CF bond is marked by a peculiar combination of polarity on nonpolarizability (hardness); this imbues fluorinated compounds with polar hydrophobicity. This property, whereby desolvation of fluorinated surfaces and weak dipolar interactions in organized media drive molecular recognition (see schematic representation), is argued to be a useful design principle and a likely explanation for the abundance of fluorinated compounds in medicinal chemistry.

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Metadata

Authors
Biffinger, J. C., Kim, H. W., & DiMagno, S. G.
Venue
ChemBioChem
Publisher
Wiley
Published
2004-04-28
Volume
5
Issue
5
Pages
622-627
ISSN
  • 1439-4227 (ISSN-L)
  • 1439-7633
DOI
10.1002/cbic.200300910
OpenAlex
W2159065552
Cited by
486
References
1
FWCI
9.97
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: The Polar Hydrophobicity of Fluorinated Compounds. https://app.cochat.ai/papers/10.1002/cbic.200300910
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Biffinger, J. C., Kim, H. W., & DiMagno, S. G. (2004). The Polar Hydrophobicity of Fluorinated Compounds. ChemBioChem. https://doi.org/10.1002/cbic.200300910

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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