Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents: Recent Developments

Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules

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The Polar Hydrophobicity of Fluorinated Compounds

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Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy

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Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications

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Tactics and strategies for the synthesis of iminosugar C-glycosides: a review

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Sugar-mimicking glycosidase inhibitors: bioactivity and application

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Targeted drugs by olefin metathesis: piperidine-based iminosugars

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Glycogen metabolism in cancer

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Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors

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Synthesis and biological activity of naturally occurring α-glucosidase inhibitors

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Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase

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Kinetic and crystallographic studies on 2‐(β‐D‐glucopyranosyl)‐5‐methyl‐1, 3, 4‐oxadiazole, ‐benzothiazole, and ‐benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site

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ABO(H) Blood Group A and B Glycosyltransferases Recognize Substrate via Specific Conformational Changes

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Glycogen Phosphorylase Inhibition in Type 2 Diabetes Therapy

Baker, D. J., Timmons, J. A., & Greenhaff, P. L. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2453 · Cited by 87 · see citing works

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition

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Synthesis of 1-(d-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors

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1,3-Dipolar cycloaddition reactions on carbohydrate-based templates: synthesis of spiro-isoxazolines and 1,2,4-oxadiazoles as glycogen phosphorylase inhibitors

Benltifa, M., Vidal, S., Gueyrard, D., Goekjian, P. G., Msaddek, M., & Praly, J. (2006) · Tetrahedron Letters · doi:10.1016/j.tetlet.2006.06.058 · Cited by 85 · see citing works

Glucose derived inhibitors of glycogen phosphorylase

Somsák, L. (2010) · Comptes Rendus Chimie · doi:10.1016/j.crci.2010.09.004 · Cited by 81 · see citing works

Characterization of 1,4‐dideoxy‐1,4‐imino‐ d ‐arabinitol (DAB) as an inhibitor of brain glycogen shunt activity

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In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

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Asymmetric synthesis of 1-deoxynojirimycin and its congeners from a common chiral building block

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A New Route to Diverse 1-Azasugars fromN-Boc-5-hydroxy-3-piperidene as a Common Building Block

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A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional sudanese plants with anti-diabetic potential

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Iminosugars as Potential Inhibitors of Glycogenolysis: Structural Insights into the Molecular Basis of Glycogen Phosphorylase Inhibition

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Glycogen metabolism and the homeostatic regulation of sleep

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Gene Expression Profile Change and Associated Physiological and Pathological Effects in Mouse Liver Induced by Fasting and Refeeding

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In Search of Glycogen Phosphorylase Inhibitors: 5‐Substituted 3‐C‐Glucopyranosyl‐1,2,4‐oxadiazoles from β‐ D ‐Glucopyranosyl Cyanides upon Cyclization of O‐Acylamidoxime Intermediates

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Synthesis of N-(β-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-β-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase

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Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases

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C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB– l -isoDMDP Compared to Miglitol and Miglustat

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Pyrrolizidine Alkaloids

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Effect of glucopyranosylidene-spiro-thiohydantoin on glycogen metabolism in liver tissues of streptozotocin-induced and obese diabetic rats

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Glycogen phosphorylase inhibition as a therapeutic target: a review of the recent patent literature

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Differential Recognition of the Type I and II H Antigen Acceptors by the Human ABO(H) Blood Group A and B Glycosyltransferases

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Metathesis access to monocyclic iminocyclitol-based therapeutic agents

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A General Approach to the Synthesis of 1-Deoxy- l -iminosugars

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Synthetic, enzyme kinetic, and protein crystallographic studies of C -β- d -glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase

Kantsadi, A. L., Bokor, É., Kun, S., Stravodimos, G. A., Chatzileontiadou, D. S. M., Leonidas, D. D., Juhász‐Tóth, É., Szakács, A., Batta, G., Docsa, T., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.06.049 · Cited by 42 · see citing works

Facile Aza‐Claisen Rearrangement of Glycals: Application in the Synthesis of 1‐Deoxy‐ L ‐iminosugars

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Synthesis, structural elucidation, antioxidant, CT-DNA binding and molecular docking studies of novel chloroquinoline derivatives: Promising antioxidant and anti-diabetic agents

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Identification, Synthesis, and Characterization of New Glycogen Phosphorylase Inhibitors Binding to the Allosteric AMP Site

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General synthesis and biological evaluation of α-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-α-C-glycosides)

Goujon, J., Gueyrard, D., Compain, P., et al. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.12.043 · Cited by 39 · see citing works

Amino-functionalized iminocyclitols: synthetic glycomimetics of medicinal interest

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Iminosugars as a new class of cholinesterase inhibitors

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Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase

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Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies

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Efficient and Stereodivergent Syntheses of D ‐ and L ‐Fagomines and Their Analogues

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Analogues of insulin secretagogue (2S,3R,4S)-4-hydroxyisoleucine: synthesis by 1,3-dipolar cycloaddition reactions of chiral nitrones to alkenes

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The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: An intermediate conformation with T‐state and R‐state features

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Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis

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Synthesis of new β-1-C-alkylated imino-l-iditols: A comparative study of their activity as β-glucocerebrosidase inhibitors

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Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice

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An expeditious one-pot synthesis of 1,6-dideoxy-N-alkylated nojirimycin derivatives and their inhibitory effects on the secretion of IFN-γ and IL-4

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Novel design principle validated: Glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent

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A new asymmetric synthetic route to substituted piperidines

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A new synthetic access to bicyclic polyhydroxylated alkaloid analogues from pyranosides

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Probing multivalency for the inhibition of an enzyme: glycogen phosphorylase as a case study

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In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C‐ D ‐Glycopyranosylbenzo(hydro)quinones – Inhibition of and Binding to Glycogen Phosphorylase in the Crystal

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Total synthesis of (+)-valienamine and (−)-1-epi-valienamine via a highly diastereoselective allylic amination of cyclic polybenzyl ether using chlorosulfonyl isocyanate

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Inhibition of human salivary α-amylase by glucopyranosylidene-spiro-thiohydantoin

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Expeditious Synthesis of a Common Intermediate of l -1-Deoxyallonojirimycin and l -1-Deoxymannojirimycin

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Synthesis of Thiohydantoin-Castanospermine Glycomimetics as Glycosidase Inhibitors

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Aza-Claisen rearrangement of 2-C-hydroxymethyl glycals as a versatile strategy towards synthesis of isofagomine and related biologically important azasugars

Reddy, Y. S., Kancharla, P. K., Roy, R., & Vankar, Y. D. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob06851f · Cited by 30 · see citing works

Crystallographic and computational studies on 4‐phenyl‐N‐(β‐ D ‐glucopyranosyl)‐1H‐1,2,3‐triazole‐1‐acetamide, an inhibitor of glycogen phosphorylase: Comparison with α‐ D ‐glucose, N‐acetyl‐β‐ D ‐glucopyranosylamine and N‐benzoyl‐N′‐β‐ D ‐glucopyranosyl urea binding

Alexacou, K.-M., Hayes, J. M., Tiraidis, C., Zographos, S. E., Leonidas, D. D., Chrysina, E. D., Archontis, G., Oikonomakos, N. G., Paul, J. V., Varghese, B., et al. (2007) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21837 · Cited by 30 · see citing works

Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors

Arora, I., Kashyap, V. K., Singh, A., Dasgupta, A., Kumar, B. N., & Shaw, A. K. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00486h · Cited by 29 · see citing works

First Total Synthesis of 1-O-β- d -Glucopyranosyl-5-deoxyadenophorine and Its Aglycon Congener: Determination of the Absolute Configuration

Felpin, F., Boubekeur, K., & Lebreton, J. (2004) · The Journal of Organic Chemistry · doi:10.1021/jo035522m · Cited by 29 · see citing works

Tetrazoles and Related Heterocycles as Promising Synthetic Antidiabetic Agents

Трифонов, Р. Е., & Ostrovskii, V. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417190 · Cited by 28 · see citing works

Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient

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Synthesis of Aminocyclitols and Trihydroxylated Indolizidinone from a D ‐Mannitol‐Derived Common Building Block

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Preparation of a Stable Bicyclic Aziridinium Ion and Its Ring Expansion toward Piperidines and Azepanes

Choi, J., Yadav, N. N., & Ha, H. (2017) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201700080 · Cited by 28 · see citing works

Stereocontrolled Access to Orthogonally Protected anti,anti-4-Aminopiperidine-3,5-diols through Chemoselective Reduction of Enantiopure β-Lactam Cyanohydrins

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Glycosidase Inhibitors: Structure, Activity, Synthesis, and Medical Relevance

Bols, M., López, Ó., & Ortega‐Caballero, F. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00100-8 · Cited by 30 · see citing works

Iminosugar C-Nitromethyl Glycoside: Stereoselective Synthesis of Isoxazoline and Isoxazole-Fused Bicyclic Iminosugars

Prasad, S. S., & Baskaran, S. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b02803 · Cited by 26 · see citing works

Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-l-lyxofuranose

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Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities

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Spectroscopic investigation (FT-IR, FT-Raman), HOMO–LUMO, NBO analysis and molecular docking study of 4-chlorophenyl quinoline-2-carboxylate

Fazal, E., Panicker, C. Y., Varghese, H. T., et al. (2015) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2015.01.089 · Cited by 26 · see citing works

Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes

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Preliminary Studies on the Transformation of Nitrosugars into Branched Chain Iminosugars: Synthesis of 1,4-Dideoxy-4-C-hydroxymethyl- 1,4-imino-pentanols

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Straightforward carbamoylation of nucleophilic compounds employing organic azides, phosphines, and aqueous trialkylammonium hydrogen carbonate

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Rapid and practical synthesis of (−)-1-deoxyaltronojirimycin

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A Facile Synthesis of Lentiginosine Analogues Based on a Highly Regio‐ and Diastereoselective Allylic Amination Using Chlorosulfonyl Isocyanate

Kim, I. S., Li, Q. R., Dong, G. R., Kim, Y. C., Hong, Y. J., Lee, M., Chi, K., Oh, J. S., & Jung, Y. H. (2010) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200901443 · Cited by 25 · see citing works

Uncatalyzed One-Pot Synthesis of Highly Substituted Pyridazines and Pyrazoline-Spirooxindoles via Domino SN/Condensation/Aza-ene Addition Cyclization Reaction Sequence

Zohreh, N., & Alizadeh, A. (2013) · ACS Combinatorial Science · doi:10.1021/co400005y · Cited by 25 · see citing works

Stereocontrolled synthesis of thiohydantoin spironucleosides from sugar spiroacetals

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Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs

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Stereodivergent Access to Polyhydroxylated 10-Azabicyclo[4.3.1]decanes as New Calystegine Analogues

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