The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Monitoring in Real Time with a Microelectrode the Release of Reactive Oxygen and Nitrogen Species by a Single Macrophage Stimulated by its Membrane Mechanical Depolarization
Abstract
Macrophages are key cells of the immune system. During phagocytosis, the macrophage engulfs a foreign bacterium, virus, or particle into a vacuole, the phagosome, wherein oxidants are produced to neutralize and decompose the threatening element. These oxidants derive from in situ production of superoxide and nitric oxide by specific enzymes. However, the chemical nature and sequence of release of these compounds is far from being completely determined. The aim of the present work was to study the fundamental mechanism of oxidant release by macrophages at the level of a single cell, in real time and quantitatively. The tip of a microelectrode was positioned at a micrometric distance from a macrophage in a culture to measure oxidative‐burst release by the cell when it was submitted to physical stimulation. The ensuing release of electroactive reactive oxygen and nitrogen species was detected by amperometry and the exact nature of the compounds was characterized through comparison with in vitro electrochemical oxidation of H 2 O 2, ONOO−, NO., and NO 2− solutions. These results enabled the calculation of time variations of emission flux for each species and the reconstruction of the original flux of production of primary species, O 2.− and NO., by the macrophage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
Does oxidative damage to DNA increase with age?
Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768
The role of free radicals in asbestos-induced diseases
Kamp, D. W., Graceffa, P., Pryor, W. A., & Weitzman, S. A. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90117-y · Cited by 428
Cited by
Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress
Amatore, C., Arbault, S., Guille, M., & Lemaître, F. (2008) · Chemical Reviews · doi:10.1021/cr068062g · Cited by 406
Self-citationIn-Vivo Electrochemistry: What Can We Learn about Living Systems?
Wilson, G. S., & Johnson, M. A. (2008) · Chemical Reviews · doi:10.1021/cr068082i · Cited by 178
Qi, Y.-T., Zhang, F.-L., Tian, S.-Y., Wu, H.-Q., Zhao, Y., Zhang, X.-W., Liu, Y.-L., Fu, P., Amatore, C., & Huang, W.-H. (2024) · Nature Nanotechnology · doi:10.1038/s41565-023-01575-0 · Cited by 65
Self-citation
Metadata
- Authors
- Amatore, C., Arbault, S., Bouton, C., Coffi, K., Drapier, J., Ghandour, H., & Tong, Y.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2006-03-27
- Volume
- 7
- Issue
- 4
- Pages
- 653-661
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W1983203947
- Cited by
- 165
- References
- 4
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Monitoring in Real Time with a Microelectrode the Release of Reactive Oxygen and Nitrogen Species by a Single Macrophage Stimulated by its Membrane Mechanical Depolarization. https://app.cochat.ai/papers/10.1002/cbic.200500359
- The paper
- Amatore, C., Arbault, S., Bouton, C., Coffi, K., Drapier, J., Ghandour, H., & Tong, Y. (2006). Monitoring in Real Time with a Microelectrode the Release of Reactive Oxygen and Nitrogen Species by a Single Macrophage Stimulated by its Membrane Mechanical Depolarization. ChemBioChem. https://doi.org/10.1002/cbic.200500359
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
