The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An Evaluation of Peptide‐Bond Isosteres
Open accessAbstract
Peptide‐bond isosteres can enable a deep interrogation of the structure and function of a peptide or protein by amplifying or attenuating particular chemical properties. In this Minireview, the electronic, structural, and conformational attributes of four such isosteres—thioamides, esters, alkenes, and fluoroalkenes—are examined in detail. In particular, the ability of these isosteres to partake in noncovalent interactions is compared with that of the peptide bond. The consequential perturbations provide a useful tool for chemical biologists to reveal new structure–function relationships, and to endow peptides and proteins with desirable attributes.
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Radzicka, A., & Wolfenden, R. (1996) · Journal of the American Chemical Society · doi:10.1021/ja954077c · Cited by 484
Cited by
Newberry, R. W., & Raines, R. T. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00121 · Cited by 494
Self-citationEfficient Site-Specific Incorporation of Thioamides into Peptides on a Solid Support
Mukherjee, S., Verma, H., & Chatterjee, J. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b01484 · Cited by 71
Eildal, J. N. N., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, K., & Jemth, P. (2013) · Journal of the American Chemical Society · doi:10.1021/ja402875h · Cited by 61
Construction of Thioamide Peptides from Chiral Amino Acids
Liao, Y., Zhang, S., & Jiang, X. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202303625 · Cited by 27
Metadata
- Authors
- Choudhary, A., & Raines, R. T.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2011-07-12
- Volume
- 12
- Issue
- 12
- Pages
- 1801-1807
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W2058259501
- Cited by
- 259
- References
- 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- green
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