Thiol Redox and p Ka Properties of Mycothiol, the Predominant Low‐Molecular‐Weight Thiol Cofactor in the Actinomycetes
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The thiol p Ka and standard redox potential of mycothiol, the major low‐molecular‐weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.
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ERG has an unusually high midpoint potential for a thiol, being +0·06 V.
“Its midpoint potential for a thiol is consequently unusually high, being +0·06 V v. −0·2 to −0·4 V for typical thiols including glutathione(4,39–41) and mycothiol(42,43), and −0·193 V for the also somewhat oxidising thiol cofactor coenzyme M, which is 2-mercaptoethanesulfonate(44).”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [43]
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Self-citation
- Authors
- Sharma, S. V., Van Laer, K., Messens, J., & Hamilton, C. J.
- Affiliations
- University of East Anglia (GB)
- Department of Structural Biology VIB 1050 Brussels Belgium
- Vrije Universiteit Brussel (BE)
- Corresponding author
- Hamilton, Chris J.
- Venue
- ChemBioChem
- Publisher
- Wiley
- Published
- 2016-07-28
- Volume
- 17
- Issue
- 18
- Pages
- 1689-1692
- ISSN
- 1439-4227 (ISSN-L)
- 1439-7633
- OpenAlex
- W2463171632
- Cited by
- 26
- References
- 33
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 6 · 2017: 4
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- ChemBioChem (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Leverhulme Trust (RPG-2012-506)
- Vlaams Instituut voor Biotechnologie
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- mycothiol, thiol pKa, standard redox potential, actinomycetes
- MeSH terms
- Coenzymes, Cysteine, Glycopeptides, Hydrogen-Ion Concentration, Inositol, Molecular Conformation, Molecular Weight, Oxidation-Reduction, Sulfhydryl Compounds, Actinobacteria
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