The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid‐Phase Peptide Synthesis and Chemoselective Oxime Ligation
Abstract
The α v β 3 integrin receptor plays an important role in human metastasis and tumor‐induced angiogenesis. Targeting this receptor may provide information about the receptor status of the tumor and enable specific therapeutic planning. Solid‐phase peptide synthesis of multimeric cyclo(‐RGDfE‐)‐peptides is described, which offer the possibility of enhanced integrin targeting due to polyvalency effects. These peptides contain an aminooxy group for versatile chemoselective oxime ligation. Conjugation with para‐trimethylstannylbenzaldehyde results in a precursor for radioiododestannylation, which would allow them to be used as potential tools for targeting and imaging α v β 3‐expressing tumor cells. The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions.
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Cites
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251
Cited by
Liu, S. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900167c · Cited by 344
RGD peptide-based non-viral gene delivery vectors targeting integrin α v β 3 for cancer therapy
Fu, S., Xu, X., Ma, Y., Zhang, S., & Zhang, S. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2018.1455841 · Cited by 139
Metadata
- Authors
- Thumshirn, G., Hersel, U., Goodman, S. L., & Kessler, H.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2003-05-21
- Volume
- 9
- Issue
- 12
- Pages
- 2717-2725
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2120172300
- Cited by
- 269
- References
- 2
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid‐Phase Peptide Synthesis and Chemoselective Oxime Ligation. https://app.cochat.ai/papers/10.1002/chem.200204304
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- Thumshirn, G., Hersel, U., Goodman, S. L., & Kessler, H. (2003). Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid‐Phase Peptide Synthesis and Chemoselective Oxime Ligation. Chemistry – A European Journal. https://doi.org/10.1002/chem.200204304
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