RGD peptide-based non-viral gene delivery vectors targeting integrin α v β 3 for cancer therapy
Abstract
Integrin αvβ3 is restrictedly expressed on angiogenic blood vessels and tumour cells. It plays a key role in angiogenesis for tumour growth and metastasis. RGD peptide can specifically recognise the integrin αvβ3, which serves as targeted molecular for anti-angiogenesis strategies. Therefore, the targeted delivery of therapeutics by RGD peptide-based non-viral vectors to tumour vasculature and tumour cells is recognised as a promising approach for treating cancer. In this review, we illustrate the interaction between RGD peptide and integrin αvβ3 from different perspectives. Meanwhile, four types of RGD peptide-based non-viral gene delivery vectors for cancer therapy, including RGD-based cationic polymers, lipids, peptides and hybrid systems, are summarised. The aim is to particularly highlight the enhanced therapeutic effects and specific targeting ability exhibited by these vectors for cancer gene therapy both in vitro and in vivo.
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Targeting αvβ3 enhances delivery of nanoparticles to angiogenic vessels, improving extravasation of nanodrugs in tumors.
“Thus, targeting αvβ3 enhances the delivery of NPs to the angiogenic vessels, improving the extravasation of nanodrugs in tumors [46].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [46]
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- Authors
- Fu, S., Xu, X., Ma, Y., Zhang, S., & Zhang, S.
- Affiliations
- Dalian University of Technology (CN)
- Dalian Minzu University (CN)
- Corresponding author
- Zhang, Shubiao
- Zhang, Shufen
- Venue
- Journal of drug targeting
- Publisher
- Informa UK Limited
- Published
- 2018-04-06
- Volume
- 27
- Issue
- 1
- Pages
- 1-11
- ISSN
- 1026-7158 (ISSN-L)
- 1061-186X
- 1029-2330
- OpenAlex
- W2791696217
- Cited by
- 139
- References
- 110
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 27 · 2020: 24 · 2019: 15 · 2018: 2
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of drug targeting (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National High-Tech Research and Development Program of China (2014AA020707)
- National Natural Science Foundation of China (21503035, 21606041, 21176046)
- Fundamental Research Funds for the Central Universities (DC201502020205, DC201501076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- RGD peptide, integrin αvβ3, non-viral vectors, cancer gene therapy, anti-angiogenic therapy, cationic polymers, lipid nanoparticles, hybrid vectors, tumour metastasis
- MeSH terms
- Animals, Genetic Vectors, Humans, Neoplasms, Neovascularization, Pathologic, Oligopeptides, Genetic Therapy, Gene Transfer Techniques, Integrin alphaVbeta3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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