Cited by 139RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryCell Adhesion Molecules Research

RGD peptide-based non-viral gene delivery vectors targeting integrin α v β 3 for cancer therapy

Fu, Shuang, Xu, Xiaodong, Ma, Yu, Zhang, Shubiao, Zhang, Shufen·2019·Journal of drug targeting

Abstract

Integrin αvβ3 is restrictedly expressed on angiogenic blood vessels and tumour cells. It plays a key role in angiogenesis for tumour growth and metastasis. RGD peptide can specifically recognise the integrin αvβ3, which serves as targeted molecular for anti-angiogenesis strategies. Therefore, the targeted delivery of therapeutics by RGD peptide-based non-viral vectors to tumour vasculature and tumour cells is recognised as a promising approach for treating cancer. In this review, we illustrate the interaction between RGD peptide and integrin αvβ3 from different perspectives. Meanwhile, four types of RGD peptide-based non-viral gene delivery vectors for cancer therapy, including RGD-based cationic polymers, lipids, peptides and hybrid systems, are summarised. The aim is to particularly highlight the enhanced therapeutic effects and specific targeting ability exhibited by these vectors for cancer gene therapy both in vitro and in vivo.

Integrity signals

Registry

Crossref · 10.1080/1061186x.2018.1455841

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109 of 109 references verified0 citation errors · 0 not checkable

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  • Targeting αvβ3 enhances delivery of nanoparticles to angiogenic vessels, improving extravasation of nanodrugs in tumors.

    “Thus, targeting αvβ3 enhances the delivery of NPs to the angiogenic vessels, improving the extravasation of nanodrugs in tumors [46].”

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Authors
Fu, S., Xu, X., Ma, Y., Zhang, S., & Zhang, S.
Affiliations
  • Dalian University of Technology (CN)
  • Dalian Minzu University (CN)
Corresponding author
  • Zhang, Shubiao
  • Zhang, Shufen
Venue
Journal of drug targeting
Published
2018-04-06
Volume
27
Issue
1
Pages
1-11
ISSN
  • 1026-7158 (ISSN-L)
  • 1061-186X
  • 1029-2330
OpenAlex
W2791696217
Cited by
139
References
110
Citations by year
2026: 13 · 2025: 9 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 27 · 2020: 24 · 2019: 15 · 2018: 2
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of drug targeting (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National High-Tech Research and Development Program of China (2014AA020707)
  • National Natural Science Foundation of China (21503035, 21606041, 21176046)
  • Fundamental Research Funds for the Central Universities (DC201502020205, DC201501076)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
RGD peptide, integrin αvβ3, non-viral vectors, cancer gene therapy, anti-angiogenic therapy, cationic polymers, lipid nanoparticles, hybrid vectors, tumour metastasis
MeSH terms
Animals, Genetic Vectors, Humans, Neoplasms, Neovascularization, Pathologic, Oligopeptides, Genetic Therapy, Gene Transfer Techniques, Integrin alphaVbeta3

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