The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Fluorine‐Containing Drugs Approved by the FDA in 2018
Abstract
Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluorine‐containing drugs approved by the food and drug administration (FDA) in 2018. The newly approved pharmaceuticals feature several types of aromatic F and CF 3, as well as aliphatic (CF 2) substitution, offering advances in the treatment of various diseases, including cancer, HIV, malarial and smallpox infections.
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Wang, J., Sánchez-Roselló, M., Aceña, J. L., del Pozo, C., Sorochinsky, A. E., Fustero, S., Soloshonok, V. A., & Liu, H. (2014) · Chemical Reviews · doi:10.1021/cr4002879 · Cited by 4,847
Self-citationMulticomponent Reactions with Isocyanides
Dömling, A., & Ugi, I. (2000) · Angewandte Chemie · doi:10.1002/1521-3773(20000915)39:18<3168::aid-anie3168>3.0.co;2-u · Cited by 4,077
Zhou, Y., Wang, J., Gu, Z., Wang, S., Zhu, W., Aceña, J. L., Soloshonok, V. A., Izawa, K., & Liu, H. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00392 · Cited by 2,808
Self-citationFluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
Meanwell, N. A. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01788 · Cited by 2,655
Ilardi, E. A., Vitaku, E., & Njardarson, J. T. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401375q · Cited by 1,604
Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer
Smith, M. R., Saad, F., Chowdhury, S., Oudard, S., Hadaschik, B. A., Graff, J. N., Olmos, D., Mainwaring, P. N., Lee, J. Y., Uemura, H., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1715546 · Cited by 1,344
The Current State of Peptide Drug Discovery: Back to the Future?
Henninot, A., Collins, J. C., & Nuss, J. M. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00318 · Cited by 1,113
A Simple Catalytic Method for the Conversion of Aryl Bromides to Arylamines
Guram, A. S., Rennels, R. A., & Buchwald, S. L. (1995) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199513481 · Cited by 1,070
Solomon, B. J., Besse, B., Bauer, T. M., Felip, E., Soo, R. A., Camidge, D. R., Chiari, R., Bearz, A., Lin, C.-C., Gadgeel, S. M., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30649-1 · Cited by 791
Shaw, A. T., Felip, E., Bauer, T. M., Besse, B., Navarro, A., Postel-Vinay, S., Gainor, J. F., Johnson, M., Dietrich, J., James, L. P., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30680-0 · Cited by 659
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Contribution of Organofluorine Compounds to Pharmaceuticals
Inoue, M., Sumii, Y., & Shibata, N. (2020) · ACS Omega · doi:10.1021/acsomega.0c00830 · Cited by 1,944
Chemical Aspects of Human and Environmental Overload with Fluorine
Han, J., Kiss, L., Mei, H., Remete, A. M., Ponikvar-Svet, M., Sedgwick, D. M., Roman, R., Fustero, S., Moriwaki, H., & Soloshonok, V. A. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01263 · Cited by 537
Self-citationZhang, C., Yan, K., Fu, C., Peng, H., Hawker, C. J., & Whittaker, A. K. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00632 · Cited by 493
Next generation organofluorine containing blockbuster drugs
Han, J., Remete, A. M., Dobson, L. S., Kiss, L., Izawa, K., Moriwaki, H., Soloshonok, V. A., & O’Hagan, D. (2020) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2020.109639 · Cited by 313
Self-citationFluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity
Yu, Y., Liu, A., Dhawan, G., Mei, H., Zhang, W., Izawa, K., Soloshonok, V. A., & Han, J. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.05.042 · Cited by 182
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Metadata
- Authors
- Mei, H., Han, J., Fustero, S., Medio‐Simon, M., Sedgwick, D. M., Santi, C., Ruzziconi, R., & Soloshonok, V. A.
- Venue
- Chemistry – A European Journal
- Publisher
- Wiley
- Published
- 2019-07-08
- Volume
- 25
- Issue
- 51
- Pages
- 11797-11819
- ISSN
- 0947-6539 (ISSN-L)
- 1521-3765
- OpenAlex
- W2945137288
- Cited by
- 454
- References
- 87
- FWCI
- 26.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mei, H., Han, J., Fustero, S., Medio‐Simon, M., Sedgwick, D. M., Santi, C., Ruzziconi, R., & Soloshonok, V. A. (2019). Fluorine‐Containing Drugs Approved by the FDA in 2018. Chemistry – A European Journal. https://doi.org/10.1002/chem.201901840
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