Blood Transfusion and In-hospital Outcomes in Anemic Patients with Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Open accessAbstract
Studies have shown poor prognostic implications of anemia in patients with myocardial infarction (MI) and in patients undergoing percutaneous coronary intervention (PCI). The impact of blood transfusion in these populations remains controversial. The objective of this study was to examine the effect of transfusion on in-hospital mortality in anemic patients undergoing PCI for MI. Data from 67,051 PCIs (June 1, 1997 to January 31, 2004) were prospectively collected in a multicenter registry (Blue Cross Blue Shield of Michigan Cardiovascular Consortium). Of these, 4,623 patients who were classified as anemic according to the World Health Organization criteria underwent PCI within 7 days of presentation with acute MI. A propensity score for being transfused was estimated for each patient, and propensity matching and a prediction model for in-hospital death were developed. The average age was 67.8 years, 57.7% of patients were men, and 22.3% of patients received a transfusion during hospitalization. Transfused patients, compared to nontransfused patients, were more likely to be older, female, have lower preprocedure hemoglobin levels, more comorbidities, and a higher unadjusted in-hospital mortality rate (14.52% vs. 3.01%, p < 0.0001). After adjustment for comorbidities and propensity for transfusion, blood transfusion was associated with a higher risk of in-hospital mortality (adjusted odds ratio = 2.02, 95% confidence interval 1.47-2.79, p < 0.0001). In anemic patients undergoing PCI for MI, transfusion was associated with an increased crude and adjusted rate of in-hospital mortality. A randomized controlled trial is needed to determine the value of transfusion and the ideal transfusion criteria.
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Big cohort/epidemiological studies show associations between anemia and cardiovascular complications.
“Interestingly, there are big cohort/epidemiological studies showing associations between anemia and cardiovascular complications (48, 87, 91).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [87]
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Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
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- Authors
- Jani, S. M., Smith, D. E., Share, D., Kline-Rogers, E., Khanal, S., O'Donnell, M. J., Gardin, J., & Moscucci, M.
- Affiliations
- University of Michigan (US)
- Blue Cross Blue Shield of Michigan Foundation (US)
- Henry Ford Hospital (US)
- St. John Hospital & Medical Center (US)
- Corresponding author
- Moscucci, Mauro
- Venue
- Clinical Cardiology
- Publisher
- Wiley
- Published
- 2007
- Volume
- 30
- Issue
- S2
- Pages
- II49-II56
- ISSN
- 0160-9289 (ISSN-L)
- 1932-8737
- PMC
- PMC6653766
- OpenAlex
- W2146092403
- Cited by
- 54
- References
- 29
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 8 · 2012: 5
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Cardiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Keywords
- blood transfusion, anemia, myocardial infarction, percutaneous coronary intervention, in-hospital mortality, propensity score matching, hemoglobin, comorbidities, transfusion thresholds
- MeSH terms
- Aged, Aged, 80 and over, Anticoagulants, Blood Transfusion, Female, Hemorrhage, Hospitalization, Humans, Male, Michigan, Myocardial Infarction, Postoperative Complications, Prospective Studies, Angioplasty, Balloon, Coronary, Outcome Assessment, Health Care
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