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A review of responsive MRI contrast agents: 2005–2014
Open accessAbstract
This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency or superparamagnetism of the agent. These characteristics can be affected by changes in concentrations or activities of enzymes, proteins, nucleic acids, metabolites, or metal ions, or changes in redox state, pH, temperature, or light. A total of 117 examples are presented, including ones that employ nuclei other than 1 H, which attests to the creativity of multidisciplinary research efforts to develop responsive MRI contrast agents. Copyright © 2014 John Wiley & Sons, Ltd.
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Smith-Bindman, R., Miglioretti, D. L., Johnson, E., Lee, C., Feigelson, H. S., Flynn, M., Greenlee, R. T., Kruger, R. L., Hornbrook, M. C., Roblin, D., et al. (2012) · JAMA · doi:10.1001/jama.2012.5960 · Cited by 898
In vivo imaging of glucose uptake and metabolism in tumors
Walker-Samuel, S., Ramasawmy, R., Torrealdea, F., Rega, M., Rajkumar, V., Johnson, S. P., Richardson, S., Gonçalves, M., Parkes, H. G., Årstad, E., et al. (2013) · Nature Medicine · doi:10.1038/nm.3252 · Cited by 479
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Rivnay, J., Wang, H., Fenno, L., Deisseroth, K., & Malliaras, G. G. (2017) · Science Advances · doi:10.1126/sciadv.1601649 · Cited by 514
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Ni, D., Bu, W., Ehlerding, E. B., Cai, W., & Shi, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00316a · Cited by 484
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Jones, K. M., Pollard, A. C., & Pagel, M. D. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25838 · Cited by 287
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Metadata
- Authors
- Hingorani, D. V., Bernstein, A. S., & Pagel, M. D.
- Venue
- Contrast Media & Molecular Imaging
- Publisher
- Wiley
- Published
- 2014-10-29
- Volume
- 10
- Issue
- 4
- Pages
- 245-265
- ISSN
- 1555-4309 (ISSN-L)
- 1555-4317
- OpenAlex
- W1858389955
- Cited by
- 199
- References
- 2
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- green
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