The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Molecular pathogenesis of colorectal cancer: Implications for molecular diagnosis
Abstract
Colorectal cancer is the third leading cause of cancer‐related death in both men and woman in industrialized countries. Major advances have been made in our understanding of molecular events leading to formation of adenomatous polyps and cancer. Most colorectal cancers are sporadic, but a significant proportion (5–6%) has a clear genetic background. It is now widely accepted that colorectal carcinogenesis is a multistep process involving the inactivation of a variety of tumor‐suppressor and DNA‐repair genes and simultaneous activation of certain oncogenes. In addition, epigenetic alterations through aberrant promoter methylation and histone modification have been found to play a major role in the evolution and progression of a large proportion of sporadic colon cancers. Consequently, it is now apparent that individual colorectal cancers may evolve through diverse molecular pathways. In this article, the authors have summarized the current knowledge of molecular pathogenesis in common hereditary syndromes and sporadic forms of colorectal cancer. Novel molecular diagnostic tools for the early diagnosis and prevention of colorectal cancer that have emerged from these insights are discussed. Cancer 2005. © 2005 American Cancer Society.
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Cites
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · cited 2×
“Microsatellite instability Tumors that develop through inactivation of tumorsuppressor genes and multiple allelic losses are referred to as having “chromosomal instability” (CIN) and evolve through the “suppressor” pathway.(46) Although this model was the initial model for multistep tumor progression, we now know that…”
BackgroundThe Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927
Ribic, C. M., Sargent, D. J., Moore, M. J., Thibodeau, S. N., French, A. J., Goldberg, R. M., Hamilton, S. R., Laurent-Puig, P., Gryfe, R., Shepherd, L. E., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022289 · Cited by 2,160
Arnold, C. N., Goel, A., & Boland, C. R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11176 · Cited by 280
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Cited by
Duffy, M. J., van Dalen, A., Haglund, C., Hansson, L., Holinski-Feder, E., Klapdor, R., Lamerz, R., Peltomaki, P., Sturgeon, C., & Topolcan, O. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.03.021 · Cited by 506
Comparative Evaluation of Immunochemical Fecal Occult Blood Tests for Colorectal Adenoma Detection
Hundt, S., Haug, U., & Brenner, H. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-3-200902030-00005 · Cited by 330
Mouse Model of Colonic Adenoma-Carcinoma Progression Based on Somatic Apc Inactivation
Hinoi, T., Akyol, A., Theisen, B. K., Ferguson, D. O., Greenson, J. K., Williams, B. O., Cho, K. R., & Fearon, E. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2735 · Cited by 314
Interactive relationships between intestinal flora and bile acids
Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206
Challenging homeostasis to define biomarkers for nutrition related health
van Ommen, B., Keijer, J., Heil, S. G., & Kaput, J. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800390 · Cited by 167
Metadata
- Authors
- Arnold, C. N., Goel, A., Blum, H. E., & Richard Boland, C.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2005-10-04
- Volume
- 104
- Issue
- 10
- Pages
- 2035-2047
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2145339991
- Cited by
- 162
- References
- 5
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
