Cited by 167Nutrition, Genetics, and DiseaseNutrition and Health StudiesNutritional Studies and Diet

Challenging homeostasis to define biomarkers for nutrition related health

Open access
van Ommen, Ben, Keijer, Jaap, Heil, Sandra G., Kaput, Jim·2009·Molecular Nutrition & Food Research

Abstract

A primary goal of nutrition research is to optimize health and prevent or delay disease. Biomarkers to quantify health optimization are needed since many if not most biomarkers are developed for diseases. Quantifying "normal homeostasis" and developing validated biomarkers are formidable tasks because of the robustness of homeostasis and of inter-individual diversity. In this paper, we discuss the science, strategies, and technologies for measuring parameters that define individual health. The following concepts are central to define the physiology of the healthy individual: (i) responses to a challenge of homeostasis will be more informative than static homeostatic measures; (ii) processes involved in maintaining homeostasis usually are multi-factorial and require quantitative analyses of the many individual components involved; (iii) health includes a large variation in "normality" and the effects of nutritional interventions may remain hidden in this "diversity of robustness," if incompletely analyzed. Specifically, comprehensive multi-parameter ("omics") analysis may identify key parameters (biomarkers) and lead to a greater understanding of health supporting processes. Perturbation tests that accurately target aspects of the overarching drivers of health (metabolism, oxidation, inflammation, and psychological stress) may be instrumental in creating knowledge for maintaining health and preventing disease through nutrition.

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Crossref · 10.1002/mnfr.200800390

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Authors
van Ommen, B., Keijer, J., Heil, S. G., & Kaput, J.
Affiliations
  • Wageningen University & Research (NL)
  • National Center for Toxicological Research (US)
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2009-07
Volume
53
Issue
7
Pages
795-804
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2006163696
Cited by
167
References
102
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 11 · 2014: 13 · 2013: 21 · 2012: 15
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • TNO Repository (submittedVersion)
  • Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
homeostasis, biomarkers, omics, interindividual variability, health optimization, disease prevention, metabolism, oxidation, inflammation, psychological stress, dietary intervention
MeSH terms
Animals, Health, Homeostasis, Humans, Individuality, Nutritional Physiological Phenomena, Biomarkers

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