Challenging homeostasis to define biomarkers for nutrition related health
Open accessAbstract
A primary goal of nutrition research is to optimize health and prevent or delay disease. Biomarkers to quantify health optimization are needed since many if not most biomarkers are developed for diseases. Quantifying "normal homeostasis" and developing validated biomarkers are formidable tasks because of the robustness of homeostasis and of inter-individual diversity. In this paper, we discuss the science, strategies, and technologies for measuring parameters that define individual health. The following concepts are central to define the physiology of the healthy individual: (i) responses to a challenge of homeostasis will be more informative than static homeostatic measures; (ii) processes involved in maintaining homeostasis usually are multi-factorial and require quantitative analyses of the many individual components involved; (iii) health includes a large variation in "normality" and the effects of nutritional interventions may remain hidden in this "diversity of robustness," if incompletely analyzed. Specifically, comprehensive multi-parameter ("omics") analysis may identify key parameters (biomarkers) and lead to a greater understanding of health supporting processes. Perturbation tests that accurately target aspects of the overarching drivers of health (metabolism, oxidation, inflammation, and psychological stress) may be instrumental in creating knowledge for maintaining health and preventing disease through nutrition.
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Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works
Toxicology and risk assessment of coumarin: Focus on human data
Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900281 · Cited by 292 · see citing works
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Picó, C., Serra, F., Rodríguez, A. M., Keijer, J., & Palou, A. (2019) · Nutrients · doi:10.3390/nu11051092 · Cited by 287 · see citing works
Self-citationRizzardini, G., Eskesen, D., Calder, P. C., Capetti, A., Jespersen, L., & Clerici, M. (2012) · British Journal Of Nutrition · doi:10.1017/s000711451100420x · Cited by 217 · see citing works
Phenotypic flexibility as key factor in the human nutrition and health relationship
van Ommen, B., van der Greef, J., Ordovas, J. M., & Daniel, H. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0423-5 · Cited by 133 · see citing works
Self-citationShi, W., Hegeman, M. A., van Dartel, D. A. M., Tang, J., Suarez, M., Swarts, H., van der Hee, B., Arola, L., & Keijer, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600878 · Cited by 62 · see citing works
West, N. P., Pyne, D. B., Cripps, A., Christophersen, C. T., Conlon, M. A., & Fricker, P. A. (2012) · Gut Microbes · doi:10.4161/gmic.19579 · Cited by 48 · see citing works
- Authors
- van Ommen, B., Keijer, J., Heil, S. G., & Kaput, J.
- Affiliations
- Wageningen University & Research (NL)
- National Center for Toxicological Research (US)
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2009-07
- Volume
- 53
- Issue
- 7
- Pages
- 795-804
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2006163696
- Cited by
- 167
- References
- 102
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 11 · 2014: 13 · 2013: 21 · 2012: 15
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- homeostasis, biomarkers, omics, interindividual variability, health optimization, disease prevention, metabolism, oxidation, inflammation, psychological stress, dietary intervention
- MeSH terms
- Animals, Health, Homeostasis, Humans, Individuality, Nutritional Physiological Phenomena, Biomarkers
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