The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Risk factors for chemotherapy‐associated venous thromboembolism in a prospective observational study
Open accessAbstract
BACKGROUND: The incidence of venous thromboembolism (VTE) is increased in cancer, but little information is available about risk factors in cancer patients on chemotherapy. METHODS: We analyzed data from a prospective, multicenter observational study to determine the frequency and risk factors for VTE in ambulatory cancer patients initiating a new chemotherapy regimen. The association of VTE with clinical variables was characterized using univariate and multivariate analysis. RESULTS: Among 3003 patients treated with at least one cycle of chemotherapy, VTE occurred in 58 (1.93%) over a median follow‐up of 2.4 months (0.8%/mo). The incidence varied significantly by site of cancer (P = 0.01) with highest rates in upper gastrointestinal (2.3%/mo) and lung cancer (1.2%/mo), and lymphoma (1.1%/mo). An elevated prechemotherapy platelet count was significantly associated with an increased rate of VTE (P for trend = 0.005). The incidence of VTE was 3.98% (1.66%/mo) for patients with a prechemotherapy platelet count ≥ 350,000, compared with 1.25% (0.52%/mo) for patients with platelet counts of < 200,000 (P for trend=0.0003). In multivariate analysis, a prechemotherapy platelet count of ≥ 350,000/mm 3 (adjusted OR 2.81, 95% CI 1.63–4.93, P = 0.0002), site of cancer, hemoglobin < 10g/dL or use of erythropoietin, and use of white cell growth factors in high‐risk sites of cancer were significantly associated with VTE. CONCLUSIONS: Symptomatic VTE is a frequent complication of chemotherapy. The prechemotherapy platelet count is a unique risk factor and can help identify high‐risk patients for future trials of thromboprophylaxis. Cancer 2005. © 2005 American Cancer Society.
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Prevention of Venous Thromboembolism
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Prevention of Venous Thromboembolism
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Cited by
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Self-citationEpidemiology of cancer-associated venous thrombosis
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Self-citationPrediction of venous thromboembolism in cancer patients
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Metadata
- Authors
- Khorana, A. A., Francis, C. W., Culakova, E., & Lyman, G. H.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2005-11-13
- Volume
- 104
- Issue
- 12
- Pages
- 2822-2829
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W1573083214
- Cited by
- 565
- References
- 42
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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