The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration
Open accessAbstract
BACKGROUND: The literature on upper tract urothelial carcinoma (UTUC) has been limited to small, single center studies. A large series of patients treated with radical nephroureterectomy for UTUC were studied, and variables associated with poor prognosis were identified. METHODS: Data on 1363 patients treated with radical nephroureterectomy at 12 academic centers were collected. All pathologic slides were re‐reviewed by genitourinary pathologists according to strict criteria. RESULTS: Pathologic review revealed renal pelvis location (64%), necrosis (21.6%), lymphovascular invasion (LVI) (24.8%), concomitant carcinoma in situ (28.7%), and high‐grade disease (63.7%). A total of 590 patients (43.3%) underwent concurrent, lymphadenectomy and 135 (9.9%) were lymph node (LN) ‐positive. Over a mean follow‐up of 51 months, 379 (28%) patients experienced disease recurrence outside of the bladder and 313 (23%) died of UTUC. The 5‐year recurrence‐free and cancer‐specific survival probabilities (±SD) were 69% ± 1% and 73% ± 1%, respectively. On multivariate analysis, high tumor grade (hazards ratio [HR]: 2.0, P < .001), advancing pathologic T stage (P‐for‐trend <.001), LN metastases (HR: 1.8, P < .001), infiltrative growth pattern (HR: 1.5, P < .001), and LVI (HR: 1.2, P = .041) were associated with disease recurrence. Similarly, patient age (HR: 1.1, P = .001), high tumor grade (HR: 1.7, P = .001), increasing pathologic T stage (P‐for‐trend <.001), LN metastases (HR: 1.7, P < .001), sessile architecture (HR: 1.5, P = .002), and LVI (HR: 1.4, P = .02) were independently associated with cancer‐specific survival. CONCLUSIONS: Radical nephroureterectomy provided durable local control and cancer‐specific survival in patients with localized UTUC. Pathologic tumor grade, T stage, LN status, tumor architecture, and LVI were important prognostic variables associated with oncologic outcomes, which could potentially be used to select patients for adjuvant systemic therapy. Cancer 2009. © 2009 American Cancer Society.
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Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439
Proportional hazards tests and diagnostics based on weighted residuals
GRAMBSCH, P. M., & THERNEAU, T. M. (1994) · Biometrika · doi:10.1093/biomet/81.3.515 · Cited by 5,885 · cited 1×
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European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 Update
Rouprêt, M., Babjuk, M., Compérat, E., Zigeuner, R., Sylvester, R. J., Burger, M., Cowan, N. C., Gontero, P., Van Rhijn, B. W. G., Mostafid, A. H., et al. (2018) · European Urology · doi:10.1016/j.eururo.2017.07.036 · Cited by 1,514
Self-citationBladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Powles, T., Bellmunt, J., Comperat, E., De Santis, M., Huddart, R., Loriot, Y., Necchi, A., Valderrama, B. P., Ravaud, A., Shariat, S. F., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2021.11.012 · Cited by 555
Self-citationEuropean Guidelines on Upper Tract Urothelial Carcinomas: 2013 Update
Rouprêt, M., Babjuk, M., Compérat, E., Zigeuner, R., Sylvester, R., Burger, M., Cowan, N., Böhle, A., Van Rhijn, B. W. G., Kaasinen, E., et al. (2013) · European Urology · doi:10.1016/j.eururo.2013.03.032 · Cited by 451
Self-citationRouprêt, M., Zigeuner, R., Palou, J., Boehle, A., Kaasinen, E., Sylvester, R., Babjuk, M., & Oosterlinck, W. (2011) · European Urology · doi:10.1016/j.eururo.2010.12.042 · Cited by 398
Self-citationRaman, J. D., Messer, J., Sielatycki, J. A., & Hollenbeak, C. S. (2011) · BJU International · doi:10.1111/j.1464-410x.2010.09675.x · Cited by 364
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Metadata
- Authors
- Margulis, V., Shariat, S. F., Matin, S. F., Kamat, A. M., Zigeuner, R., Kikuchi, E., Lotan, Y., Weizer, A., Raman, J. D., Wood, C. G., & the Upper Tract Urothelial Carcinoma Collaboration
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2009-01-20
- Volume
- 115
- Issue
- 6
- Pages
- 1224-1233
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W1980525903
- Cited by
- 1,133
- References
- 2
- FWCI
- 46.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Margulis, V., Shariat, S. F., Matin, S. F., Kamat, A. M., Zigeuner, R., Kikuchi, E., Lotan, Y., Weizer, A., Raman, J. D., Wood, C. G., & the Upper Tract Urothelial Carcinoma Collaboration. (2009). Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer. https://doi.org/10.1002/cncr.24135
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