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Cited by 173Schizophrenia research and treatmentGlobal Cancer Incidence and ScreeningSuicide and Self-Harm Studies

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Cancer mortality in patients with schizophrenia: An 11‐year prospective cohort study

Tran, Eric, Rouillon, Frédéric, Loze, Jean‐Yves, Casadebaig, Françoise, Philippe, Alain, Vitry, Fabien, Limosin, Frédéric·2009·Cancer
DOI 10.1002/cncr.24383
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Abstract

BACKGROUND: Schizophrenia has been associated with a rate of premature mortality that is 2 to 3 times higher than that in the general population. Although the role of cancer in this excess mortality remains unclear, previous incidence or mortality studies found contradictory results. METHODS: In 1993, a large prospective study was initiated in a cohort of 3470 patients with schizophrenia to examine cancer‐related mortality and predictors. Standardized mortality ratios (SMRs) were calculated, adjusting for age and sex relative to a representative sample of the French general population. RESULTS: During the 11‐year follow‐up, 476 (14%) patients died; the mortality rate was thus nearly 4‐fold higher than in the general population. Cancer was the second most frequent cause of mortality (n = 74), with a global SMR of 1.5 (95% confidence interval [95% CI], 1.2‐1.9). For all cancers, the SMRs were 1.4 (not significant) for men and 1.9 (95% CI, 1.4‐2.8) for women. For men, lung cancer was the most frequent localization (n = 23; 50%), with an SMR of 2.2 (95% CI, 1.6‐3.3). For women, breast cancer was the most frequent localization (n = 11; 39%), with an SMR of 2.8 (95% CI, 1.6‐4.9). In comparison with patients who did not die of cancer, there were 2 significant baseline predictors of death by lung cancer in the final logistic regression model: duration of smoking and age >38 years. CONCLUSIONS: The results of the current study demonstrated an increased risk of mortality by cancer in patients with schizophrenia, especially for women from breast cancer and for men from lung cancer. Cancer 2009. © 2009 American Cancer Society.

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Research works printed but not linked: 2

  1. World Health Organization, 1994, The ICD‐10 classification of mental and behavioural disorders: diagnostic criteria for research
  2. Catts VS, 2007, No in vitro anti‐cancer effect of antipsychotic drugs at doses used in the psychiatric clinic, Schizophr Bull., 33, 230

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Metadata

Authors
Tran, E., Rouillon, F., Loze, J., Casadebaig, F., Philippe, A., Vitry, F., & Limosin, F.
Affiliations
  • Université de Reims Champagne-Ardenne (FR)
  • Université Paris Cité (FR)
  • Inserm (FR)
ORCID
Limosin, Frédéric
Venue
Cancer
Publisher
Wiley
Published
2009-06-22
Volume
115
Issue
15
Pages
3555-3562
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
DOI
10.1002/cncr.24383
OpenAlex
W2021564981
Cited by
173
References
33
Citations by year
2026: 6 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 6 · 2015: 10 · 2014: 9 · 2013: 20 · 2012: 15
FWCI
8.43
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Keywords
schizophrenia, cancer mortality, premature mortality, lung cancer, breast cancer, sex differences, smoking duration, standardized mortality ratio, mortality risk factors
MeSH terms
Adolescent, Adult, Breast Neoplasms, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neoplasms, Schizophrenia

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