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Percutaneous image‐guided cryoablation of painful metastases involving bone: Multicenter trial

Open access
Callstrom, Matthew R., Dupuy, Damian E., Solomon, Stephen B., Beres, Robert A., Littrup, Peter J., Davis, Kirkland W., Paz‐Fumagalli, Ricardo, Hoffman, Cheryl, Atwell, Thomas D., Charboneau, J. William, Schmit, Grant D., Goetz, Matthew P., Rubin, Joseph, Brown, Kathy J., Novotny, Paul J., Sloan, Jeff A.·2013·Cancer

Abstract

BACKGROUND: This study sought to describe the results of a single‐arm multicenter clinical trial using image‐guided percutaneous cryoablation for the palliation of painful metastatic tumors involving bone. METHODS: Over a 44‐month period, 61 adult patients with 1 or 2 painful bone metastases with a score of 4 or more on a scale of 0 to 10 (≥4/10) worst pain in a 24‐hour period who had failed or refused conventional treatment were treated with percutaneous image‐guided cryoablation. Patient pain and quality of life was measured using the Brief Pain Inventory prior to treatment, 1 and 4 days after the procedure, weekly for 4 weeks, and every 2 weeks thereafter for a total of 6 months. Patient analgesic use was also recorded at these same follow‐up intervals. Complications were monitored. Analysis of the primary endpoint was undertaken via paired comparison procedures. RESULTS: A total of 69 treated tumors ranged in size from 1 to 11 cm. Prior to cryoablation, the mean score for worst pain in a 24‐hour period was 7.1/10 with a range of 4/10 to 10/10. At 1, 4, 8, and 24 weeks after treatment, the mean score for worst pain in a 24‐hour period decreased to 5.1/10 (P < .0001), 4.0/10 (P < .0001), 3.6/10 (P < .0001), and 1.4/10 (P < .0001), respectively. One of 61 (2%) patients had a major complication with osteomyelitis at the site of ablation. CONCLUSIONS: Percutaneous cryoablation is a safe, effective, and durable method for palliation of pain due to metastatic disease involving bone. Cancer 2013. © 2012 American Cancer Society.

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Metadata

Authors
Callstrom, M. R., Dupuy, D. E., Solomon, S. B., Beres, R. A., Littrup, P. J., Davis, K. W., Paz‐Fumagalli, R., Hoffman, C., Atwell, T. D., Charboneau, J. W., Schmit, G. D., Goetz, M. P., Rubin, J., Brown, K. J., Novotny, P. J., & Sloan, J. A.
Venue
Cancer
Publisher
Wiley
Published
2012-10-12
Volume
119
Issue
5
Pages
1033-1041
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
OpenAlex
W1576244230
Cited by
298
References
22
FWCI
16.54
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Percutaneous image‐guided cryoablation of painful metastases involving bone: Multicenter trial. https://app.cochat.ai/papers/10.1002/cncr.27793
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Callstrom, M. R., Dupuy, D. E., Solomon, S. B., Beres, R. A., Littrup, P. J., Davis, K. W., Paz‐Fumagalli, R., Hoffman, C., Atwell, T. D., Charboneau, J. W., Schmit, G. D., Goetz, M. P., Rubin, J., Brown, K. J., Novotny, P. J., & Sloan, J. A. (2013). Percutaneous image‐guided cryoablation of painful metastases involving bone: Multicenter trial. Cancer. https://doi.org/10.1002/cncr.27793

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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