The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer
Open accessAbstract
BACKGROUND: RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and brain. METHODS: We performed a computerized search of the electronic medical record of our institution for mCRC cases genotyped for RAS or PIK3CA mutations from 2008 to 2012. Cases were reviewed for patient characteristics, survival, and site‐specific metastasis. RESULTS: Among the 918 patients identified, 477 cases were RAS wild type, and 441 cases had a RAS mutation (394 at KRAS exon 2, 29 at KRAS exon 3 or 4, and 18 in NRAS). RAS mutation was significantly associated with shorter median overall survival (OS) and on multivariate analysis independently predicted worse OS (HR, 1.6; P < .01). RAS mutant mCRC exhibited a significantly higher cumulative incidence of lung, bone, and brain metastasis and on multivariate analysis was an independent predictor of involvement of these sites (HR, 1.5, 1.6, and 3.7, respectively). PIK3CA mutations occurred in 10% of the 786 cases genotyped, did not predict for worse survival, and did not exhibit a site‐specific pattern of metastatic spread. CONCLUSIONS: The metastatic potential of CRC varies with the presence of RAS mutation. RAS mutation is associated with worse OS and increased incidence of lung, bone, and brain metastasis. An understanding of this site‐specific pattern of spread may help to inform physicians' assessment of symptoms in patients with mCRC. Cancer 2015;121:1195–1203. © 2014 American Cancer Society.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“although RAS mutations have been associated with increased tendency for lung involvement in colorectal cancer (33–35).”
From Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRAS G12C-Mutated Metastatic Colorectal Cancer (2024) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
De Roock, W., Claes, B., Bernasconi, D., De Schutter, J., Biesmans, B., Fountzilas, G., Kalogeras, K. T., Kotoula, V., Papamichael, D., Laurent-Puig, P., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70130-3 · Cited by 2,144
Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study
Andreyev, J. N., Norman, A. R., Cunningham, D., Oates, J. R., Dix, B. R., Iacopetta, B. J., Young, J. P., Walsh, T. P., Ward, R. L., Hawkins, N., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1964 · Cited by 880
Tran, B., Kopetz, S., Tie, J., Gibbs, P., Jiang, Z., Lieu, C. H., Agarwal, A., Maru, D. M., Sieber, O. M., & Desai, J. (2011) · Cancer · doi:10.1002/cncr.26086 · Cited by 812
Class I PI3K in oncogenic cellular transformation
Zhao, L., & Vogt, P. K. (2008) · Oncogene · doi:10.1038/onc.2008.244 · Cited by 612
Venook, A. P., Niedzwiecki, D., Lenz, H., Innocenti, F., Mahoney, M. R., O’Neil, B. H., Shaw, J. E., Polite, B. N., Höchster, H. S., Atkins, J. N., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.32.18_suppl.lba3 · Cited by 428
Vauthey, J., Zimmitti, G., Kopetz, S., Shindoh, J., Chen, S. S., Andreou, A., Curley, S. A., Aloia, T. A., & Maru, D. M. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a5025a · Cited by 379
Ogino, S., Nosho, K., Kirkner, G. J., Shima, K., Irahara, N., Kure, S., Chan, A. T., Engelman, J. A., Kraft, P. L., Cantley, L. C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.6544 · Cited by 331
Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer
Janakiraman, M., Vakiani, E., Zeng, Z., Pratilas, C. A., Taylor, B. S., Chitale, D., Halilovic, E., Wilson, M., Huberman, K., Ricarte Filho, J. C., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0192 · Cited by 290
Self-citationComparative Genomic Analysis of Primary Versus Metastatic Colorectal Carcinomas
Vakiani, E., Janakiraman, M., Shen, R., Sinha, R., Zeng, Z., Shia, J., Cercek, A., Kemeny, N. E., D'Angelica, M. I., Viale, A. J., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.2994 · Cited by 288
Self-citation
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–187 of 187
Narayan, R. R., Datta, J., Goldman, D. A., Aveson, V. G., Walch, H. S., Sánchez-Vega, F., Gönen, M., Balachandran, V. P., Drebin, J. A., Jarnagin, W. R., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12085-z · Cited by 11
Self-citationHistological growth patterns and molecular analysis of resected colorectal lung metastases
Pilozzi, E., Fedele, D., Montori, A., Lorenzon, L., Peritore, V., Mannocchi, G., Bagheri, N., Leone, C., Palumbo, A., Roberto, M., et al. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153414 · Cited by 11
Turner, K. M., Delman, A. M., Wima, K., Quillin, R. C., Shah, S. A., Ahmad, S. A., Patel, S. H., & Wilson, G. C. (2022) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2022.08.007 · Cited by 11
Chen, Q., Le, H., Li, Y., Zuo, C., Li, M., Wu, X., Pu, C., Xu, X. M., Tang, R., Xiong, Y., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.758681 · Cited by 10
Bonadio, R. C., de Freitas, G. F., Batista, D. N., Moreira, O. A., Dias, C. A. R., Castria, T. B. D., Sabbaga, J., & Hoff, P. M. (2019) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2021.04.002 · Cited by 10
Choi, J.-Y., Lee, Y. S., Shim, D. M., Lee, Y., & Seo, S. W. (2021) · Bone and Joint Research · doi:10.1302/2046-3758.105.bjr-2020-0262.r3 · Cited by 10
Factors Prognostic for Brain Metastases from Colorectal Cancer: A Single-Center Experience in China
Wang, D., Chen, C., Ge, X., Yang, Q., Huang, Y., Ling, T., Jin, T., Yu, S., Wang, J., & Sun, L. (2021) · Cancer Management and Research · doi:10.2147/cmar.s320179 · Cited by 9
Identification of a gene expression signature associated with brain metastasis in colorectal cancer
Michl, M., Taverna, F., Woischke, C., Li, P., Klauschen, F., Kirchner, T., Heinemann, V., von Bergwelt‐Baildon, M., Stahler, A., Herold, T., et al. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03408-5 · Cited by 10
Paix, A., Antoni, D., Adeduntan, R., & Noël, G. (2017) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2017.01.010 · Cited by 9
Precision Medical Approaches to the Diagnoses and Management of Brain Metastases
Chukwueke, U. N., & Brastianos, P. K. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0649-y · Cited by 9
Kim, J. K., Marco, M. R., Choi, S., Qu, X., Chen, C., Elkabets, M., Fairchild, L., Chow, O. S., Barriga, F. M., Dow, L. E., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12960 · Cited by 10
Analysis of KRAS, BRAF and NRAS in Patients with Colorectal Cancer: the First Report of Western Iran
Payandeh, M., Sadeghi, M., Sadeghi, E., & Gholami, F. (2015) · Journal of Cancer Prevention · doi:10.12691/ajcp-3-1-5 · Cited by 8
Incidence and predictors of brain metastasis in colorectal cancer patients
Thompson, E., Banerjee, S., Thompson, S., Silva, R., Muse, A., Arif‐Tiwari, H., Scott, A. J., & Nfonsam, V. N. (2021) · International Journal of Colorectal Disease · doi:10.1007/s00384-021-04041-2 · Cited by 8
Wilson, G. D., Johnson, M. D., Ahmed, S. I., Cardenas, P. Y., Grills, I. S., & Thibodeau, B. J. (2018) · Oncotarget · doi:10.18632/oncotarget.25409 · Cited by 8
New Frontiers of Biomarkers in Metastatic Colorectal Cancer: Potential and Critical Issues
Medici, B., Benatti, S., Dominici, M., & Gelsomino, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115268 · Cited by 7
Choi, Y. S., Lee, K.-Y., Park, Y. Y., Kim, H. J., & Lee, J. (2021) · Annals of Coloproctology · doi:10.3393/ac.2020.00185.0026 · Cited by 7
Coupez, D., Hulo, P., Touchefeu, Y., Denis, M. G., & Bennouna, J. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1967318 · Cited by 8
Tang, W., Liu, Y., Ji, M., Liu, T., Chen, Y., Zhuang, A., Mao, Y., Chang, W., Wei, Y., Ren, L., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-021-11302-5 · Cited by 8
Boeckx, N., Peeters, M., Camp, G. V., Pauwels, P., de Beeck, K. O., & Deschoolmeester, V. (2015) · Drugs · doi:10.1007/s40265-015-0459-x · Cited by 7
Hatoum, L., Murr, R. E., Assi, A., Mohanna, R., Sebaaly, A., & Kourié, H. R. (2025) · Journal of bone oncology · doi:10.1016/j.jbo.2025.100727 · Cited by 6
Significance of RAS mutations in pulmonary metastases of patients with colorectal cancer
Igarashi, T., Shimizu, K., Usui, K., Yokobori, T., Ohtaki, Y., Nakazawa, S., Obayashi, K., Yajima, T., Nobusawa, S., Takahiro, O., et al. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01582-z · Cited by 6
Ge, P., Wan, N., Han, X. W., Wang, X., Zhang, J., Long, X., Wang, X., & Bian, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.914683 · Cited by 6
Duan, H., He, Z., Guo, C., Li, J.-H., Wang, J., Zhu, Z., Sai, K., Chen, Z.-P., Jiang, X., & Mou, Y. (2018) · Cancer Management and Research · doi:10.2147/cmar.s169563 · Cited by 6
Treatment of colorectal peritoneal metastases requires multidisciplinary efforts
Goèré, D., & Gelli, M. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30490-9 · Cited by 5
Jensen, G. L., Tang, C. Z., Hess, K. R., Liao, Z. X., & Gomez, D. R. (2017) · Clinical & Experimental Metastasis · doi:10.1007/s10585-017-9850-1 · Cited by 5
Sander, C., Frydrychowicz, C., Prasse, G., Taubenheim, S., Arlt, F., Meixensberger, J., & Fehrenbach, M. K. (2022) · BMC Cancer · doi:10.1186/s12885-022-09435-1 · Cited by 5
The Role of Targeted Therapy in the Multi-Disciplinary Approach to Colorectal Liver Metastasis
Ruff, S. M., Shannon, A. H., & Pawlik, T. M. (2023) · Cancers · doi:10.3390/cancers15133513 · Cited by 5
Lang, H., Baumgart, J., Roth, W., Moehler, M. H., & Kloth, M. T. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-292 · Cited by 5
Gao, G., & Deng, L. (2018) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2018.07.06 · Cited by 5
McGovern, K., Smith, M. H., Maloney, A., Jose, J., & Saif, M. W. (2021) · PubMed · Cited by 5
Collignon, C., Hansen, T. H., Hercus, C., Ruzinova, M. B., Guépin, G. R., Bonmati, C., Rubio, M., Feugier, P., Gaudfrin, M., Sartelet, H., et al. (2025) · Blood Cancer Journal · doi:10.1038/s41408-025-01345-2 · Cited by 4
The Choice of Local Treatment Modalities for Patients with Brain Metastases from Digestive Cancers
Dong, J., Wu, L., Wang, F., Huang, J., Hu, P., Zhang, B., & Xia, L. (2019) · Journal of Oncology · doi:10.1155/2019/1568465 · Cited by 4
Shoji, Y., Furuhashi, S., Kelly, D. F., Bilchik, A. J., Hoon, D. S. �., & Bustos, M. A. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10094-y · Cited by 4
Hálková, T., Ptáčková, R., Semyakina, A., Suchánek, Š., Traboulsi, E., Ngo, O., Hejcmanová, K., Májek, O., Bureš, J., Zavoral, M., et al. (2022) · Cancers · doi:10.3390/cancers14122823 · Cited by 3
Sun, P., Gu, C., Wang, H., Zhang, Y., Cao, J., Ji, J., & Zhang, M. (2025) · Discover Oncology · doi:10.1007/s12672-025-04159-7 · Cited by 3
Agy, F. E., Bardai, S. E., Boukansa, S., Bouguenouch, L., Benbrahim, Z., Mazaz, K., Benjelloun, E. B., Ousadden, A., Ouldim, K., Ibrahimi, S. A., et al. (2024) · Cancer Control · doi:10.1177/10732748241229290 · Cited by 3
Almilaji, O., Sharples, L. D., Aggarwal, A. K., Cromwell, D. A., Horgan, K. J., Braun, M., Arnott, R., Nossiter, J., Kuryba, A., Lewin, A., et al. (2025) · BMC Cancer · doi:10.1186/s12885-025-13777-x · Cited by 3
Gui, C., Walch, H. S., Mueller, K., Boe, L. A., Ilıca, A. T., Strong, J. S., Eichholz, J., Yu, K. K. H., Wilcox, J. A., Manca, P., et al. (2024) · Journal of neurosurgery · doi:10.3171/2024.5.jns24534 · Cited by 3
Self-citationBrain metastasis in colorectal cancer presenting as refractory hypertension
Hassan, S. M., Mubarik, A., Muddassir, S. M., & Haq, F. U. (2018) · Journal of Community Hospital Internal Medicine Perspectives · doi:10.1080/20009666.2018.1490138 · Cited by 4
Broström, E., Isaksson, J., Xanthoulis, P., Börjesson, R., Willén, L., Hansen, T., Holgersson, G., Ekman, S., Botling, J., Lundström, K. L., et al. (2025) · Translational Lung Cancer Research · doi:10.21037/tlcr-24-840 · Cited by 2
Genomics correlates of brain metastasis and progression in colorectal cancer
Gui, C., Walch, H. S., Mueller, K., Boe, L. A., Skakodub, A., Miao, E., Khatri, I. S., Kumar, R., Mazzeo, M. P., Shen, J., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf198 · Cited by 2
Self-citationMankuzhy, N. P., Santo, V., Shin, J. Y., Chaunzwa, T. L., Gelblum, D. Y., Wu, A. J.-C., McMillan, M. T., Ma, J., Billing, D. L., Iyengar, P., et al. (2026) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2026.103565 · Cited by 2
Brandão, G. R., Trindade, B. O., Flores, L. H. F., Motter, S. B., Alves, C. B., Remonti, T. A. P., Lucchese, A. M., Junior, A. D. P., & Kalil, A. N. (2023) · The American Surgeon · doi:10.1177/00031348231156763 · Cited by 2
Worse Survival in Co-Altered RAS-TP53 Patients With Resected Colorectal Liver Metastases
Li, J., Waller, G., Qin, Y., Yu, A. T., Li, T., Li, D., Srouji, R. M., Correa‐Gallego, C., Hiotis, S. P., Gunasekaran, G., et al. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-025-18533-w · Cited by 2
Shen, G., Li, J., Jin, Y.-H., Sun, H., Hao, Y., Jin, M., Liu, R., Li, W.-L., Zhang, Y., Yu, J., et al. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9209 · Cited by 2
Morató, O., Villamonte, M., Sánchez‐Velázquez, P., Pueyo-Périz, E. M., Grande, L., Ielpo, B., Rosso, E., Anselmo, A., & Burdı́o, F. (2022) · Healthcare · doi:10.3390/healthcare10030472 · Cited by 2
Abrudan, R., Abrudan, L., Pop, O. L., & Zaha, D. C. (2023) · Cureus · doi:10.7759/cureus.47824 · Cited by 2
Epidemiology and Socioeconomic Impact of CNS Metastases
Wilcox, J. A., & DeAngelis, L. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-42958-4_1 · Cited by 2
Li, M., Li, Z., Wu, X., Pan, Y., Wang, L., Xue, J., & Li, T. (2024) · BMC Cancer · doi:10.1186/s12885-024-13154-0 · Cited by 1
Predicting NRAS gene status in colorectal cancer using computed tomography (CT)-based radiomics
Yang, Y., Zhang, C., Chen, J., Fu, D., Zhang, X., Zhang, P., Wang, G., & Li, Z. (2025) · Clinical Radiology · doi:10.1016/j.crad.2025.107116 · Cited by 1
Current understanding and management of brain metastasis from colorectal cancer. A review
Leclerc, A., Charles, M., Lesueur, P., Dupont, B., Emery, É., & Alvès, A. (2026) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2026.01.001 · Cited by 1
Epidemiology and risk factors for metastatic colorectal disease
Ward, E. P., & Clarke, C. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91706-3.00014-x · Cited by 1
Kim, S. H., Lee, Y. S., Sung, Y. E., Sung, Y. E., Lee, A., Kang, J. K., Park, J., Lee, Y. S., & Lee, Y. S. (2023) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2023.06.10 · Cited by 1
Imai, T., Shoji, H., Hirano, H., Matsuguma, K., Awatsu, T., Hirose, T., Okita, N. T., Takashima, A., & Kato, K. (2024) · CNS Oncology · doi:10.1080/20450907.2024.2347824 · Cited by 2
Zancana, G., Armocida, D., Capobianco, M., Corvino, S., Cofano, F., Garbossa, D., Santoro, A., & Frati, A. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.07.073 · Cited by 1
Colorectal Cancer Brain Metastasis With Concomitant KRAS and BRAF Mutations: A Case Report
Vesa, A., Maghiar, O. A., Molnar, O., Pop, O. L., & Maghiar, A. M. (2024) · Cureus · doi:10.7759/cureus.68975 · Cited by 1
Evans, S. J., Moelijker, N., Brandsma, I., Burgum, M. J., Elespuru, R. K., Hendriks, G., & Doak, S. H. (2025) · Mutagenesis · doi:10.1093/mutage/geaf013 · Cited by 1
Mustafa, D. A. M., Pedrosa, R. M. S. M., & Kros, J. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-23417-1_2 · Cited by 1
Parikh, K. M., & Magge, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-42958-4_17 · Cited by 1
Management and complete resection of peritoneal and bone metastases from mucinous rectal carcinoma
Milito, P., Battaglia, L., Cosimelli, M., Antista, M., Guagliò, M., D, M. D. M., & Baratti, D. (2020) · Tumori Journal · doi:10.1177/0300891620977695 · Cited by 1
KRAS Inhibitors Are Potential Prophylaxis for Colorectal Cancer Metachronous MetastasisPreprint
Guo, Y., Hu, C., Long, G., Cai, D., Yu, Z., Huang, X., Cai, Z., Hu, P., Chen, Y., Gao, F., et al. (2024) · Preprints.org · doi:10.20944/preprints202403.1095.v1 · Cited by 1
Surgical Management of the Colorectal Cancer Patient with Simultaneous Liver and Lung Metastases
Reddy, S. K., & Al‐Sukhni, E. (2016) · Current Colorectal Cancer Reports · doi:10.1007/s11888-016-0325-6
Arackal, J. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5667
Sinha, J., Zhang, R., Patil, V., Guzmán, M. A., & Poddar, N. (2017) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-016-9911-8
Albeck, J. G., Gillies, T. E., Blizard, H., & Pargett, M. (2017)
Managing Non-Hepatic Metastatic Sites: Lung and CNS
Subbiah, I. M., Eng, C., & Lou, E. (2019) · Springer eBooks · doi:10.1007/978-3-319-98902-0_25
Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases
Squires, M. H., Cloyd, J. M., & Pawlik, T. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-25486-5_3
Shahramian, I., Parooie, F., & Salarzaei, M. (2020) · doi:10.21203/rs.2.20466/v1
Toper, M. H., Talu, C. K., Pehlivanoğlu, B., Sahin, Y., Ünlü, Ş. M., Gürel, D., Ulukuş, E. Ç., Özer, E., Koyuncuoğlu, M., Tuna, B., et al. (2022) · Springer eBooks · doi:10.1007/978-3-030-84432-5_13
Blair, A. B., Tenner, L. L., & Reames, B. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91706-3.00002-3
Patients with brain metastasis from colorectal cancerPreprint
Yu, Y., Yang, Y., Wang, N., Wu, X., & Zhang, M. (2023) · Research Square · doi:10.21203/rs.3.rs-2791775/v1
Mechanisms of Metastasis: Analysis on Abdominal Organs and the Effect of Treatment Options
Keshav, S., & Kethar, J. (2022) · Journal of Student Research · doi:10.47611/jsrhs.v11i4.3704
Ghaffar, S. A., Pfau, D., Madhuripan, N., Harmon, R. C., Neto, A. G., & Gleisner, A. (2024) · Radiology Case Reports · doi:10.1016/j.radcr.2024.01.068
Afrăsânie, V.-A. (2024) · The Medical-Surgical Journal · doi:10.22551/msj.2024.01.02
Prognostic and Predictive Factors in Metastatic Colorectal Cancer
Österlund, E. (2024) · doi:10.33063/diva-522642
A Patient With Rectal Cancer With Cranial Metastasis Resulting in Epidural Hematoma
Li, D.-R., Ji, X., Du, X., Zhang, Y., & Wang, Z. (2024) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000010943
Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations
Abdelgadir, O., Kuo, Y., Khan, M. F., Okorodudu, A. O., Cheng, Y., & Dong, J. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i3.107954
A rare case of metastatic carcinoma at the colostomy site after abdominoperineal resection
Manne, D., Tirougnanassambandamourty, T. A., & Smile, R. (2025) · International Surgery Journal · doi:10.18203/2349-2902.isj20253045
Regulatory Functions of TDP‐43 and FMRP in Non‐Neuronal Diseases: Are Co‐Targeted mRNAs the Keys?
Ahsan, A., Kar, O., Akter, K., Ta, H. D. K., Shen, C.-K. J., Datta, K., Chatterjee, B., Huang, C.-C. S., & Majumder, P. (2025) · The FASEB Journal · doi:10.1096/fj.202502281r
Sander, C., Frydrychowicz, C., Prasse, G., Taubenheim, S., Arlt, F., Meixensberger, J., & Fehrenbach, M. K. (2022) · Figshare · doi:10.6084/m9.figshare.19445804
Sander, C., Frydrychowicz, C., Prasse, G., Taubenheim, S., Arlt, F., Meixensberger, J., & Fehrenbach, M. K. (2022) · Figshare · doi:10.6084/m9.figshare.19445798
Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes
Hutchinson, H. J., Gonzalez, M., Feier, D., Welch, C. E., & Lucke-Wold, B. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i4.110961
Leclerc, A., Charles, M., Lesueur, P., Dupont, B., Emery, É., & Alvès, A. (2026) · Journal de Chirurgie Viscérale · doi:10.1016/j.jchirv.2025.12.001
Hálková, T., Pauerova, L. H., Blechová, K., Benešová, T., Grega, T., Brodyuk, N., Traboulsi, E., Hejcmanová, K., Ngo, O., Bureš, J., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156547
Manca, P., Walch, H., Xu, J., Small, N., Kris, A., Seffar, E., Richards, A. L., Xue, T., Price, A., Donoghue, M. T. A., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.08.004
Self-citationRAS–Pathway Mutation Profiles and Clinical Outcomes Among Patients With Colorectal Cancer
Kazemian, E., Liu, L., Waissengrin, B., Matejcic, M., Sobieski, D., Tsai, Y.-Y., Lorona, N. C., Nguyen, N. T., Torres, J. A. O., Cress, W. D., et al. (2026) · Cancer Medicine · doi:10.1002/cam4.72411
The molecular-genetic profile of brain metastases from colorectal cancer
Халафян, Д. А., Bekyashev, A. К., Строганова, А. М., Рогожин, Д. В., Козлов, Н. А., Насхлеташвили, Д. Р., Mitrofanov, A. A., Алешин, В. А., Sufianov, R. A., Abdulaeva, R. S., et al. (2026) · Malignant tumours · doi:10.18027/2224-5057-2026-096
Metadata
- Authors
- Yaeger, R., Cowell, E., Chou, J. F., Gewirtz, A. N., Borsu, L., Vakiani, E., Solit, D. B., Rosen, N., Capanu, M., Ladanyi, M., & Kemeny, N.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Kemeny, Nancy
- ORCID
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2014-12-09
- Volume
- 121
- Issue
- 8
- Pages
- 1195-1203
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- PMC
- PMC4523078
- OpenAlex
- W1492286179
- Cited by
- 187
- References
- 30
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 15 · 2023: 9 · 2022: 20 · 2021: 20 · 2020: 19 · 2019: 22 · 2018: 17 · 2017: 21 · 2016: 11 · 2015: 10
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA008748, R25CA020449)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- RAS mutations, PIK3CA mutation, metastatic colorectal cancer, brain metastases, lung metastasis, bone metastasis, liver metastasis, overall survival, KRAS, NRAS, metastatic potential
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bone Neoplasms, Brain Neoplasms, Female, Humans, Liver Neoplasms, Male, Membrane Proteins, Middle Aged, Mutation, Prognosis, Proto-Oncogene Proteins, Colorectal Neoplasms, Survival Analysis, Proto-Oncogene Proteins p21(ras), ras Proteins, Phosphatidylinositol 3-Kinases, GTP Phosphohydrolases, Young Adult, Class I Phosphatidylinositol 3-Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
