Association between KRAS mutation and lung metastasis in advanced colorectal cancer
Open accessAbstract
BACKGROUND: KRAS mutations have been associated with lung metastases at diagnosis of metastatic colorectal cancer (mCRC), but the impact of this mutation on subsequent development of lung metastasis is unknown. We investigated KRAS mutation as a predictor of lung metastasis development. METHODS: We retrospectively evaluated data from patients with mCRC whose tumour was tested for KRAS mutation from 2008 to 2010. The relationships of KRAS mutational status with time-to-lung metastasis (TTLM) and overall survival (OS) were analysed. RESULTS: Of the 494 patients identified, 202 (41%) had tumours with KRAS mutation. KRAS mutations were associated with a shorter TTLM (median 15.2 vs 22.4 months; hazard ratio=1.40; P=0.002) and a two-fold greater odds of developing lung metastases during the disease course in patients with liver-limited mCRC at diagnosis (72 vs 56%, P=0.007). Overall survival did not differ by KRAS status. CONCLUSIONS: Lung metastasis was more likely to develop during the disease course in patients whose tumour had a KRAS mutation than in those whose tumour did not have a KRAS mutation. This finding may have an impact on decision making for surgical resection of metastatic disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RAS mutations have been associated with an increased tendency for lung involvement in colorectal cancer.
“although RAS mutations have been associated with increased tendency for lung involvement in colorectal cancer (33–35).”
From Efficacy and Safety of Adagrasib plus Cetuximab in Patients with <i>KRAS</i> G12C-Mutated Metastatic Colorectal Cancer (2024) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Siegel, R., Naishadham, D., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21166 · Cited by 11,825 · see citing works
Panitumumab–FOLFOX4 Treatment and <i>RAS</i> Mutations in Colorectal Cancer
Douillard, J.-Y., Oliner, K. S., Siena, S., Tabernero, J., Burkes, R., Barugel, M., Humblet, Y., Bodoky, G., Cunningham, D., Jassem, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1305275 · Cited by 2,263 · see citing works
<i>KRAS</i> Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer
Lièvre, A., Bachet, J.-B., Le Corre, D., Boige, V., Landi, B., Emile, J.-F., Côté, J.-F., Tomasic, G., Penna, C., Ducreux, M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0191 · Cited by 2,229 · see citing works
Roth, A. D., Tejpar, S., Delorenzi, M., Yan, P., Fiocca, R., Klingbiel, D., Dietrich, D., Biesmans, B., Bodoky, G., Barone, C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.3452 · Cited by 1,178 · see citing works
Wood, K. W., Sarnecki, C., Roberts, T. M., & Blenis, J. (1992) · Cell · doi:10.1016/0092-8674(92)90076-o · Cited by 903 · see citing works
Hutchins, G. G. A., Southward, K., Handley, K., Magill, L., Beaumont, C., Stahlschmidt, J., Richman, S. D., Chambers, P. A., Seymour, M., Kerr, D. J., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.1366 · Cited by 681 · see citing works
Siena, S., Bianchi, A. S., Nicolantonio, F. D., Balfour, J., & Bardelli, A. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp280 · Cited by 526 · see citing works
Activation of extracellular signal‐regulated kinase, ERK2, by p21ras oncoprotein.
Leevers, S. J., & Marshall, C. J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05088.x · Cited by 496 · see citing works
Vauthey, J., Zimmitti, G., Kopetz, S., Shindoh, J., Chen, S. S., Andreou, A., Curley, S. A., Aloia, T. A., & Maru, D. M. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a5025a · Cited by 379 · see citing works
Self-citationMitry, E., Guiu, B., Cosconea, S., Jooste, V., Faivre, J., & Bouvier, A. (2010) · Gut · doi:10.1136/gut.2010.211557 · Cited by 379 · see citing works
Manfrédi, S., Bouvier, A., Lepage, C., Hatem, C., Dancourt, V., & Faivre, J. (2006) · British journal of surgery · doi:10.1002/bjs.5349 · Cited by 316 · see citing works
Santini, D., Loupakis, F., Vincenzi, B., Floriani, I., Stasi, I., Canestrari, E., Rulli, E., Maltese, P. E., Andreoni, F., Masi, G., et al. (2008) · The Oncologist · doi:10.1634/theoncologist.2008-0181 · Cited by 234 · see citing works
Tie, J., Lipton, L., Desai, J., Gibbs, P., Jorissen, R. N., Christie, M., Drummond, K. J., Thomson, B. N. J., Usatoff, V., Evans, P. M., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1720 · Cited by 217 · see citing works
Mutations of KRAS and BRAF in Primary and Matched Metastatic Sites of Colorectal Cancer
Artale, S. A., Bianchi, A. S., Veronese, S. M., Gambi, V., Sarnataro, C., Gambacorta, M., Lauricella, C., & Siena, S. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7286 · Cited by 216 · see citing works
Jimeno, A., Messersmith, W. A., Hirsch, F. R., Franklin, W. A., & Eckhardt, S. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.8168 · Cited by 216 · see citing works
Cejas, P., López-Gómez, M., Aguayo, C., Madero, R., de Castro, J., Belda-Iniesta, C., Barriuso, J., Moreno, V., Larrauri, J., López, R., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008199 · Cited by 154 · see citing works
Étienne-Grimaldi, M.-C., Formento, J., Francoual, M., François, É., Formento, P., Renée, N., Laurent‐Puig, P., Chazal, M., Benchimol, D., Delpéro, J., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4906 · Cited by 151 · see citing works
Kim, M. J., Lee, H. S., Kim, J. H., Kim, Y. J., Kwon, J. H., Lee, J., Bang, S., Park, K. U., Kim, D., Kang, S., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-347 · Cited by 141 · see citing works
KRAS Mutation Testing in Colorectal Cancer
Plesec, T. P., & Hunt, J. L. (2009) · Advances in Anatomic Pathology · doi:10.1097/pap.0b013e3181a9d4ed · Cited by 107 · see citing works
Stintzing, S., Jung, A., Rossius, L., Modest, D. P., von Weikersthal, L. F., Decker, T. W., Kiani, A., Al‐Batran, S., Vehling‐Kaiser, U., Heintges, T., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.32.3_suppl.445 · Cited by 97 · see citing works
Nash, G. M., Gimbel, M. I., Cohen, A. M., Zeng, Z., Ndubuisi, M. I., Nathanson, D. R., Ott, J., Barany, F., & Paty, P. B. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0713-0 · Cited by 92 · see citing works
Buø, L., Meling, G. I., Karlsrud, T. S., Johansen, H. T., & Aasen, A. O. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90276-7 · Cited by 66 · see citing works
Schweiger, T., Hegedűs, B., Nikolowsky, C., Hegedűs, Z., Szirtes, I., Mair, R., Birner, P., Döme, B., Láng, G., Klepetko, W., et al. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3386-7 · Cited by 57 · see citing works
Yamamoto, H., Itoh, F., Senota, A., Adachi, Y., Yoshimoto, M., Endoh, T., Hinoda, Y., Yachi, A., & Imai, K. (1995) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860090504 · Cited by 50 · see citing works
Clinical characterization of patients with metastatic colorectal cancer depending on the KRAS status
Modest, D. P., Stintzing, S., Laubender, R. P., Neumann, J. H. L., Jung, A., Giessen, C. A., Haas, M., Aubele, P., Schulz, C. U., Boeck, S. H., et al. (2011) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e3283493160 · Cited by 49 · see citing works
Jankun, J., Maher, V. M., & McCormick, J. J. (1991) · PubMed · Cited by 45 · see citing works
Incidence and Predictive Factors for Pulmonary Metastases After Curative Resection of Colon Cancer
Watanabe, K., Saito, N., Sugito, M., Ito, M., Kobayashi, A., & Nishizawa, Y. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2747-y · Cited by 37 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
From tumour heterogeneity to advances in precision treatment of colorectal cancer
Punt, C. J. A., Koopman, M., & Vermeulen, L. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.171 · Cited by 654 · see citing works
Nguyen, B., Fong, C. J., Luthra, A., Smith, S. A., DiNatale, R. G., Nandakumar, S., Walch, H. S., Chatila, W. K., Madupuri, R., Kundra, R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.003 · Cited by 616 · see citing works
KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer
Liao, W., Overman, M. J., Boutin, A. T., Shang, X., Zhao, D., Dey, P., Li, J., Wang, G., Lan, Z., Li, J., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.02.008 · Cited by 617 · see citing works
Self-citationOncogenic <i>Kras</i> drives invasion and maintains metastases in colorectal cancer
Boutin, A. T., Liao, W.-T., Wang, M., Hwang, S. S., Karpinets, T. V., Cheung, H., Chu, G. C., Jiang, S., Hu, J., Chang, K., et al. (2017) · Genes & Development · doi:10.1101/gad.293449.116 · Cited by 195 · see citing works
Self-citationThe current understanding on the impact of KRAS on colorectal cancer
Meng, M., Zhong, K., Jiang, T., Liu, Z., Kwan, H. Y., & Su, T. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111717 · Cited by 171 · see citing works
The Colorectal Cancer Tumor Microenvironment and Its Impact on Liver and Lung Metastasis
Chandra, R., Karalis, J. D., Liu, C., Murimwa, G. Z., Park, J. V., Heid, C. A., Reznik, S. I., Huang, E. H., Minna, J. D., & Brekken, R. A. (2021) · Cancers · doi:10.3390/cancers13246206 · Cited by 165 · see citing works
Genetic insights into the morass of metastatic heterogeneity
Hunter, K. W., Amin, R., Deasy, S. K., Ha, N., & Wakefield, L. M. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2017.126 · Cited by 161 · see citing works
Yaeger, R., Uboha, N. V., Pelster, M. S., Bekaii-Saab, T. S., Barve, M., Saltzman, J., Sabari, J. K., Peguero, J. A., Paulson, A. S., Jänne, P. A., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0217 · Cited by 139 · see citing works
Self-citationSakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3303 · Cited by 133 · see citing works
Bylsma, L. C., Gillezeau, C. N., Garawin, T., Kelsh, M. A., Fryzek, J. P., Sangaré, L. R., & Lowe, K. A. (2019) · Cancer Medicine · doi:10.1002/cam4.2747 · Cited by 133 · see citing works
Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer
Liu, H., Liang, Z., Zhou, C., Zeng, Z., Wang, F., Hu, T., He, X., Wu, X., Wu, X., & Lan, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00534-2 · Cited by 100 · see citing works
Stage IV colorectal cancer primary site and patterns of distant metastasis
Robinson, J. R. M., Newcomb, P. A., Hardikar, S. S., Cohen, S. A., & Phipps, A. I. (2017) · Cancer Epidemiology · doi:10.1016/j.canep.2017.04.003 · Cited by 96 · see citing works
Back to the Colorectal Cancer Consensus Molecular Subtype Future
Menter, D. G., Davis, J. S., Broom, B. M., Overman, M. J., Morris, J. S., & Kopetz, S. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0674-9 · Cited by 81 · see citing works
Self-citationRecent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
László, L., Kurilla, A., Takács, T., Kudlik, G., Koprivanacz, K., Buday, L., & Vas, V. (2021) · Cells · doi:10.3390/cells10030667 · Cited by 58 · see citing works
Lipid metabolism reprogramming in colorectal cancer
Chen, D., Zhou, X., Yan, P., Yang, C., Li, Y., Han, L., & Ren, X. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30347 · Cited by 57 · see citing works
Management of resectable colorectal lung metastases
Moorcraft, S. Y., Ladas, G., Bowcock, A. M., & Chau, I. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9774-6 · Cited by 50 · see citing works
Chen, L., Jiang, X., Li, Y., Zhang, Q., Li, Q., Zhang, X., Zhang, M., Yu, Q., & Gao, D. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.108962 · Cited by 45 · see citing works
Myeloid-Derived Suppressor Cells: A New and Pivotal Player in Colorectal Cancer Progression
Yin, K., Xia, X., Rui, K., Wang, T., & Wang, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.610104 · Cited by 42 · see citing works
Denbo, J. W., Yamashita, S., Passot, G., Egger, M. E., Chun, Y. S., Kopetz, S., Maru, D. M., Brudvik, K. W., Wei, S. H., Conrad, C. H., et al. (2016) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-016-3189-9 · Cited by 39 · see citing works
Self-citationHepatic metastasis from colorectal cancer
Aloia, T. A., & Vauthey, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34062-5.00092-3 · Cited by 38 · see citing works
Self-citationRecent Advances in Chemotherapy and Surgery for Colorectal Liver Metastases
Passot, G., Soubrane, O., Giuliante, F., Zimmitti, G., Goèré, D., Yamashita, S., & Vauthey, J. (2016) · Liver Cancer · doi:10.1159/000449349 · Cited by 37 · see citing works
Self-citationNRAS destines tumor cells to the lungs
Giannou, A. D., Marazioti, A., Kanellakis, N. I., Giopanou, I., Lilis, I., Zazara, D. E., Ntaliarda, G., Kati, D., Armenis, V., Giotopoulou, G. A., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606978 · Cited by 35 · see citing works
KRAS mutation in lung metastases from colorectal cancer: prognostic implications
Ghidini, M., Personeni, N., Bozzarelli, S., Baretti, M., Basso, G., Bianchi, P. P., Tronconi, M. C., Pressiani, T., Grizzi, F., Giordano, L., et al. (2015) · Cancer Medicine · doi:10.1002/cam4.592 · Cited by 35 · see citing works
Christensen, T. D., Palshof, J. A., Larsen, F. O., Poulsen, T. S., Høgdall, E. V. S., Pfeiffer, P., Jensen, B. V., Yilmaz, M., & Nielsen, D. L. (2018) · Acta Oncologica · doi:10.1080/0284186x.2018.1433322 · Cited by 34 · see citing works
Corsini, E. M., Mitchell, K. G., Mehran, R. J., Rice, D. C., Sepesi, B., Walsh, G. L., Swisher, S. G., Roth, J. A., Hofstetter, W. L., Vaporciyan, A. A., et al. (2019) · Journal of Surgical Oncology · doi:10.1002/jso.25630 · Cited by 33 · see citing works
Self-citationBenefit of Adjuvant Chemotherapy After Curative Resection of Lung Metastasis in Colorectal Cancer
Park, H. S., Jung, M., Shin, S. J., Heo, S. J., Kim, C. G., Lee, M. G., Beom, S., Lee, C. Y., Lee, J. G., Kim, D. J., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4951-z · Cited by 33 · see citing works
Self-citationon behalf of the BIG-RENAPE Working Group, Passot, G., Kim, B. J., Gléhen, O., Mehran, R. J., Kopetz, S., Goèré, D., Overman, M. J., Pocard, M. D., Marchal, F., et al. (2017) · Annals of Surgical Oncology · doi:10.1245/s10434-017-6141-7 · Cited by 33 · see citing works
Self-citationmiR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression
Ye, Y., Wu, P., Gu, C.-C., Deng, D., Jiao, H., Li, T., Wang, S., Wang, Y., Xiao, Z., Wei, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11016 · Cited by 32 · see citing works
Amikura, K., Akagi, K., Ogura, T., Takahashi, A., & Sakamoto, H. (2017) · Journal of Surgical Oncology · doi:10.1002/jso.24910 · Cited by 32 · see citing works
Characterizing MRI features of rectal cancers with different KRAS status
Xu, Y., Xu, Q., Ma, Y., Duan, J., Zhang, H., Liu, T., Li, L., Sun, H., Shi, K., Xie, S., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-6341-6 · Cited by 31 · see citing works
Lillemoe, H. A., Kawaguchi, Y., Passot, G., Karagkounis, G., Simoneau, È., You, Y. N., Mehran, R. J., Chun, Y. S., Tzeng, C.-W. D., Aloia, T. A., et al. (2018) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-018-3890-y · Cited by 30 · see citing works
Self-citationClinical features and KRAS mutation in colorectal cancer with bone metastasis
Park, H. S., Chun, Y. J., Kim, H. S., Kim, J. H., Lee, C., Beom, S., Shin, S. J., & Ahn, J. B. (2020) · Scientific Reports · doi:10.1038/s41598-020-78253-x · Cited by 28 · see citing works
Gao, W., Xu, Y., Chen, T., Du, Z., Liu, X., Hu, Z., Wei, D., Gao, C., Zhang, W., & Li, Q. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000425 · Cited by 26 · see citing works
The genomic landscape of metastasis in treatment-naïve breast cancer models
Ross, C. R., Szczepanek, K., Lee, M. Y., Yang, H. H., Qiu, T., Sanford, J. D., & Hunter, K. W. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008743 · Cited by 25 · see citing works
Self-citationSchweiger, T., Liebmann‐Reindl, S., Glueck, O., Starlinger, P. P., Laengle, J., Birner, P., Klepetko, W., Pils, D., Streubel, B., & Höetzenecker, K. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.10.72 · Cited by 25 · see citing works
Andreatos, N., Ronnekleiv‐Kelly, S. M., Margonis, G. A., Sasaki, K., Gani, F., Amini, N., Wilson, A., & Pawlik, T. M. (2016) · Surgical Oncology · doi:10.1016/j.suronc.2016.07.002 · Cited by 23 · see citing works
Renaud, S., Guerrera, F., Seitlinger, J., Costardi, L., Schaeffer, M., Romain, B., Mossetti, C., Claire-Voegeli, A., Filosso, P. L., Legrain, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13697 · Cited by 23 · see citing works
Metastatic Profile of Colorectal Cancer: Interplay Between Primary Tumor Location and KRAS Status
Yong, Z. Z., Ching, G. T. H., & Ching, M. T. C. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2018.11.025 · Cited by 20 · see citing works
Optimization of melting analysis with TaqMan probes for detection of KRAS, NRAS, and BRAF mutations
Botezatu, I. V., Nechaeva, I. O., Строганова, А. М., Senderovich, A. I., Kondratova, V. N., Shelepov, V. P., & Lichtenstein, A. V. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.09.005 · Cited by 19 · see citing works
Lu, J., Raghuram, D., Fong, P.-S. A., & Gong, Z. (2018) · Neoplasia · doi:10.1016/j.neo.2018.10.002 · Cited by 20 · see citing works
KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer
Choi, S., Kim, J. K., Chen, C., Wu, C., Marco, M. R., Barriga, F. M., O’Rourke, K. P., Pelossof, R. A., Qu, X., Chang, Q., et al. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0994 · Cited by 17 · see citing works
Dang, Y., Yu, J., Zhao, S., Cao, X., & Wang, Q. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02519-9 · Cited by 18 · see citing works
Berg, K. C. G., Brunsell, T. H., Sveen, A., Alagaratnam, S., Bjørnslett, M., Hektoen, M., Brudvik, K. W., Røsok, B. I., Bjørnbeth, B. A., Nesbakken, A., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12885 · Cited by 18 · see citing works
Kawasaki, H., Saotome, T., Usui, T., Ohama, T., & Sato, K. (2017) · Oncology Reports · doi:10.3892/or.2017.5520 · Cited by 16 · see citing works
Cho, M. T. (2016) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v8.i1.128 · Cited by 15 · see citing works
Can molecular biomarkers replace a clinical risk score for resectable colorectal liver metastasis?
Veen, T., & Søreide, K. (2017) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v9.i3.98 · Cited by 15 · see citing works
RAS GTPase signalling to alternative effector pathways
Singh, S., & Smith, M. J. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200506 · Cited by 15 · see citing works
He, W., Wang, L., Yin, C., Yi, J., Jin, Y., Jiang, C., Guo, G., & Xia, L. (2022) · Cancer Medicine · doi:10.1002/cam4.5417 · Cited by 13 · see citing works
van Dorp, M., González, M., Daddi, N., Batırel, H. F., Brunelli, A., & Schreurs, W. H. (2023) · Interdisciplinary CardioVascular and Thoracic Surgery · doi:10.1093/icvts/ivad002 · Cited by 12 · see citing works
Lung Metastasis Predicts Better Prognosis in Metastatic Colorectal Cancer With Mutated KRAS
Margalit, O., Shacham‐Shmueli, E., Lawrence, Y. R., Yang, Y., Reiss, K. A., Golan, T., Mamtani, R., Halpern, N., Aderka, D., Giantonio, B. J., et al. (2019) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2019.06.001 · Cited by 12 · see citing works
Guo, Y., Hu, C., Cai, K., Long, G., Cai, D., Yu, Z., Huang, X., Cai, Z., Hu, P., Chen, Y., et al. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13389 · Cited by 11 · see citing works
Biomarker alterations associated with distinct patterns of metastatic spread in colorectal cancer
Michl, M., Taverna, F., Kumbrink, J., Schiergens, T. S., Heinemann, V., Engel, J., Kirchner, T., & Neumann, J. H. L. (2020) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02983-6 · Cited by 11 · see citing works
Narayan, R. R., Datta, J., Goldman, D. A., Aveson, V. G., Walch, H. S., Sánchez-Vega, F., Gönen, M., Balachandran, V. P., Drebin, J. A., Jarnagin, W. R., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12085-z · Cited by 11 · see citing works
Histological growth patterns and molecular analysis of resected colorectal lung metastases
Pilozzi, E., Fedele, D., Montori, A., Lorenzon, L., Peritore, V., Mannocchi, G., Bagheri, N., Leone, C., Palumbo, A., Roberto, M., et al. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153414 · Cited by 11 · see citing works
Peristalsis-Associated Mechanotransduction Drives Malignant Progression of Colorectal Cancer
Clevenger, A. J., McFarlin, M. K., Collier, C. A., Sheshadri, V. S., Madyastha, A. K., Gorley, J. P. M., Solberg, S. C., Stratman, A. N., & Raghavan, S. A. (2023) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-023-00776-w · Cited by 10 · see citing works
Wang, H., Shan, X., Zhang, M., Qian, K., Shen, Z., & Zhou, W. (2022) · BMC Gastroenterology · doi:10.1186/s12876-022-02270-5 · Cited by 10 · see citing works
Oncological benefit of complete metastasectomy for simultaneous colorectal liver and lung metastases
Matsumura, M., Yamashita, S., Ishizawa, T., Akamatsu, N., Kaneko, J., Arita, J., Nakajima, J., Kokudo, N., & Hasegawa, K. (2019) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2019.06.007 · Cited by 9 · see citing works
Yanai, Y., Hayashi, T., Akazawa, Y., Yatagai, N., Tsuyama, S., Yao, T., & Saito, T. (2020) · Oncology Letters · doi:10.3892/ol.2020.11627 · Cited by 7 · see citing works
CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series
Wang, F.-M., Luo, R., Tian, J.-M., Liu, H., & Yang, J. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338231201508 · Cited by 6 · see citing works
Clevenger, A. J., Collier, C. A., Gorley, J. P. M., Colijn, S., McFarlin, M. K., Solberg, S. C., Kopetz, S., Stratman, A. N., & Raghavan, S. A. (2024) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-24-0624 · Cited by 6 · see citing works
Self-citationChen, S., Huang, W., Liu, Z., Jin, M., Li, J., Meng, L., Li, T., Diao, Y., Gao, H., Hong, C., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.5233 · Cited by 5 · see citing works
Wang, S., Chen, L., Feng, Y., Swinnen, J. V., Jonscher, C., Ongeval, C. V., & Ni, Y. (2022) · Cancers · doi:10.3390/cancers14071608 · Cited by 5 · see citing works
Genetic Characteristics of Resectable Colorectal Cancer with Pulmonary Metastasis
Qiu, Y.-Y., Peng, D., Wei, Z., Li, J.-D., Huang, Y.-J., Yang, J., Song, Z., & Cheng, Y. (2022) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2022/2033876 · Cited by 5 · see citing works
Defining Resectability of Colorectal Cancer Liver Metastases: Technical and Oncologic Perspectives
Marcus, R. K., & Aloia, T. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-25486-5_11 · Cited by 4 · see citing works
Management of patients with colorectal liver metastasis in eleven questions and answers
Andrès, A., Majno, P. E., Terraz, S., Morel, P., Roth, A. D., Rubbia‐Brandt, L., Schiffer, E. R. C., Ris, F., & Toso, C. (2016) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2016.1249855 · Cited by 4 · see citing works
Agy, F. E., Bardai, S. E., Boukansa, S., Bouguenouch, L., Benbrahim, Z., Mazaz, K., Benjelloun, E. B., Ousadden, A., Ouldim, K., Ibrahimi, S. A., et al. (2024) · Cancer Control · doi:10.1177/10732748241229290 · Cited by 3 · see citing works
Knijn, N., van de Water, C., van Vliet, S., Meijer, J. W. R., Riemersma, S. A., Tebar, M., Punt, C. J. A., Mekenkamp, L. J., Simmer, F., & Nagtegaal, I. D. (2019) · Applied cancer research/Applied Cancer Research · doi:10.1186/s41241-019-0079-y · Cited by 3 · see citing works
Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells
Wong, H. L., Ng, L. P. W., Koh, S. P., Chan, L., Wong, E. Y. K., Xue, V. W., Tsang, H. F., Chan, A. K. C., Chiu, K. Y., Cheuk, W., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24921 · Cited by 3 · see citing works
Colorectal cancer biomarkers and their impact on the clinical practice
Crespo, J., Victorino, A. P., Araujo, K., Araujo, L. H., & Vieira, F. M. D. A. C. (2021) · Brazilian Journal of Oncology · doi:10.5935/2526-8732.20210025 · Cited by 3 · see citing works
Zhou, Y., Wang, D., Tan, F., Zhou, Z., Zhao, L., Güngör, C., Pei, Q., Li, Y., & Liu, W. (2022) · Journal of Cancer · doi:10.7150/jca.70894 · Cited by 2 · see citing works
Sakellaropoulos, T., Hur, J., Melas, I. N., Guo, E. Y., Alexopoulos, L. G., Bohlooly, M., & Bai, J. P. F. (2015) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.09.005 · Cited by 2 · see citing works
Scanning for KRAS, NRAS, BRAF, and PIK3CA mutations by DNA melting analysis with TaqMan probes
Botezatu, I. V., Panchuk, I., Строганова, А. М., Senderovich, A. I., Kondratova, V. N., Shelepov, V. P., & Lichtenstein, A. V. (2017) · Molecular Biology · doi:10.1134/s002689331701006x · Cited by 2 · see citing works
Qu, W., Sun, Y., Zhang, W., Jiang, Z., Han, Y., Jin, J., Xue, Q., & Zhou, A. (2023) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13918 · Cited by 1 · see citing works
Self-citationAoki, Y., Miki, A., Sakuma, Y., Watanabe, J., Kagaya, T., Tahara, M., Teratani, T., Endo, K., Sasanuma, H., Nishimura, W., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0324719 · Cited by 1 · see citing works
Clinical and prognostic implications of RAS mutations in metastatic colorectal cancer
Ataca, E., Keskinkılıç, M., Sarıoğlu, S., Başbınar, Y., & Yavuzşen, T. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-04180-w · Cited by 1 · see citing works
Tumor mutational burden as a determinant of metastatic dissemination patterns
Candeal, E., Moreno‐Manuel, A., Salvadó‐Pertierra, M., Vivas, C. S., & Pamplona, R. S. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70200 · Cited by 1 · see citing works
Emerging biomarkers in pulmonary metastasectomy
Lang, C., Höetzenecker, K., & Schweiger, T. (2019) · Journal of Visualized Surgery · doi:10.21037/jovs.2019.03.20 · Cited by 1 · see citing works
Epidemiology and risk factors for metastatic colorectal disease
Ward, E. P., & Clarke, C. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91706-3.00014-x · Cited by 1 · see citing works
High-density pulmonary lesions: Review in chest imaging
Jaramillo, C., Ferguson, E., Odisio, E. G., & Ocazionez, D. (2024) · Current Problems in Diagnostic Radiology · doi:10.1067/j.cpradiol.2024.07.004 · Cited by 1 · see citing works
Arvide, E. M., & Velasco, J. D. (2016) · Journal of the Advanced Practitioner in Oncology · doi:10.6004/jadpro.2016.7.7.10 · Cited by 1 · see citing works
Malfeasance of KRAS mutations in carcinogenesis
Tripathi, R., Nathany, S., Mehta, A., Batra, U., Mattoo, S., & Sharma, M. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-021-00694-z · Cited by 1 · see citing works
Surgical Management of the Colorectal Cancer Patient with Simultaneous Liver and Lung Metastases
Reddy, S. K., & Al‐Sukhni, E. (2016) · Current Colorectal Cancer Reports · doi:10.1007/s11888-016-0325-6
Shahramian, I., Parooie, F., & Salarzaei, M. (2020) · doi:10.21203/rs.2.20466/v1
Operation or systemic therapy in case of resectable metastases?
Levchenko, E. (2021) · Practical oncology · doi:10.31917/2204255
Variability in surgical treatment of metastatic colorectal cancer (literature review)
Dobrodeev, А. Y., Костромицкий, Д. Н., Afanasyev, S. G., Тарасова, А. С., Николаевна, Б. Н., & Ponomareva, A. A. (2023) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2023-22-2-160-167
Clinicopathological correlations between colorectal cancer and genetic mutations
Vesa, A., Maghiar, O. A., Pop, O. L., Boros, M., Paşcalău, A. V., & Maghiar, A. M. (2023) · Romanian Journal of Medical Practice · doi:10.37897/rjmp.2023.3.7
Liu, Y., Dou, J., Tan, Q., Chen, S., Li, Y., Wang, R., Sun, N., & Qi, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-95513-w
Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations
Abdelgadir, O., Kuo, Y., Khan, M. F., Okorodudu, A. O., Cheng, Y., & Dong, J. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i3.107954
Dang, Y., Yu, J., Zhao, S., Cao, X., & Wang, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19204242
Wang, H., Shan, X., Zhang, M., Qian, K., Shen, Z., & Zhou, W. (2022) · Figshare · doi:10.6084/m9.figshare.19613971
Sayed, M. E., Harati, M. E., Shealy, M. W., & Youssef, S. (2026) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-026-01439-5
Lin, K., Wang, C., Qiao, B., Zhang, N., Yang, D., Jin, D., Li, C., Lv, J., He, M., Lin, Z., et al. (2026) · JCO Precision Oncology · doi:10.1200/po-25-00858
Treatment of patients with R AS-mutated colorectal cancer with lung metastases
Murzakhanova, K. I., Кузнецова, О. А., Makiev, G. G., Олегович, Л. Д., Eroshin, Y. V., Khudoerov, D. K., & Tryakin, A. A. (2026) · Malignant tumours · doi:10.18027/2224-5057-2026-068
Heterogeneity in cancer: molecular mechanisms and therapeutic strategies
He, Y., Niu, L., Ren, Y.-M., Yuan, G.-Q., Pan, Y.-W., & Jin, W. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-03064-x
- Authors
- Pereira, A. A. L., Rego, J. F. M., Morris, V, Overman, M. J., Eng, C., Garrett, C. R., Boutin, A. T., Ferrarotto, R., Lee, M., Jiang, Z.-Q., Hoff, P. M., Vauthey, J.-N., Vilar, E., Maru, D., & Kopetz, S.
- Affiliations
- Universidade de São Paulo (BR)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Pereira, A A L
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2014-12-23
- Volume
- 112
- Issue
- 3
- Pages
- 424-428
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC4453646
- OpenAlex
- W2015952772
- Cited by
- 94
- References
- 27
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 5
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA016672)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- KRAS mutation, lung metastasis, metastatic colorectal cancer, overall survival, prognostic factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Lung Neoplasms, Male, Middle Aged, Mutation, Proto-Oncogene Proteins, Retrospective Studies, Colorectal Neoplasms, Proto-Oncogene Proteins p21(ras), Disease Progression, ras Proteins, Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
