Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation
Open accessAbstract
BACKGROUND: During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS: We conducted a prospective longitudinal study of patients hospitalized for HCT. They assessed QOL using the Functional Assessment of Cancer Therapy‐Bone Marrow Transplantation (FACT‐BMT) and depression and anxiety symptoms were assessed using the Patient Health Questionnaire‐9 (PHQ‐9) at the time of admission for HCT, during hospitalization, and 6 months after HCT. We also used the Hospital Anxiety and Depression Scale (HADS) to measure patients' anxiety and depression symptoms at baseline and during HCT hospitalization. The PTSD Checklist was used to assess for PTSD symptoms. Multivariable linear regression models were used to identify predictors of QOL and PTSD symptoms at 6 months. RESULTS: We enrolled 90 of 93 consecutively eligible patients (97%) undergoing autologous and allogeneic HCT. Data at 6 months were available for 67 participants. At 6 months, 28.4% of participants met the criteria for PTSD and 43.3% had clinically significant depression. On multivariable regression analyses adjusting for significant covariates, changes in QOL and depression scores from week 2 of HCT hospitalization to baseline predicted worse QOL (changes in scores between week 2 and baseline [Δ] QOL: β, 0.94 [ P <.0001] and Δ PHQ‐9: β, −2.59 [ P = 0.001]) and PTSD symptoms (Δ QOL: β, −0.40 [ P <.0001] and Δ PHQ‐9: β, 1.26 [ P <.0001]) at 6 months after HCT. CONCLUSIONS: Six months after HCT, a significant percentage of patients met the criteria for PTSD and depression. A decline in QOL and an increase in depressive symptoms during hospitalization for HCT were found to be the most important predictors of 6‐month QOL impairment and PTSD symptoms. Therefore, managing symptoms of depression and QOL deterioration during HCT hospitalization may be critical to improving QOL at 6 months and reducing the risk of PTSD. Cancer 2016;122:806–812. © 2015 American Cancer Society .
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The HSCT patient population experiences a particularly high level of psychological distress and related sequelae.
“it is not surprising that this patient population experiences a particularly high level of psychological distress and related sequelae [11, 12]”
From Mindfulness, Experiential Avoidance, and Recovery From Hematopoietic Stem Cell Transplantation. (2019) · cites this paper as [11]
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Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
The National Comprehensive Cancer Network
McGivney, W. T. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980515)82:10+ · Cited by 16,760 · see citing works
Depression and quality of life in older persons: A review
Sivertsen, H., Bjørkløf, G. H., Engedal, K., Selbæk, G., & Helvik, A.-S. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000437299 · Cited by 14,152 · see citing works
Sorror, M. L., Maris, M. B., Storb, R., Baron, F., Sandmaier, B. M., Maloney, D. G., & Storer, B. (2005) · Blood · doi:10.1182/blood-2005-05-2004 · Cited by 2,969 · see citing works
Majhail, N. S., Rizzo, J. D., Lee, S. J., Aljurf, M. D., Atsuta, Y., sup, C. B. S., sup, L. J. B. S., sup, N. C. S., sup, S. D. S., sup, S. O. S., et al. (2012) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.5581/1516-8484.20120032 · Cited by 533 · see citing works
McQuellon, R., Russell, G., Cella, D., Craven, B., Brady, M., Bonomi, A., & Hurd, D. (1997) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1700672 · Cited by 466 · see citing works
Andrykowski, M. A., Cordova, M. J., Studts, J. L., & Miller, T. W. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.66.3.586 · Cited by 454 · see citing works
Andrykowski, M. A., Cordova, M. J., Studts, J. L., & Miller, T. W. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.3.586 · Cited by 454 · see citing works
Majhail, N. S., Rizzo, J. D., Lee, S. J., et al. (2011) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2011.12.519 · Cited by 365 · see citing works
Recovery and Long-term Function After Hematopoietic Cell Transplantation for Leukemia or Lymphoma
Syrjala, K. L. (2004) · JAMA · doi:10.1001/jama.291.19.2335 · Cited by 350 · see citing works
Quality of life after allogeneic hematopoietic cell transplantation
Pidala, J., Anasetti, C., & Jim, H. (2009) · Blood · doi:10.1182/blood-2008-10-182592 · Cited by 316 · see citing works
Mosher, C. E., Redd, W. H., Rini, C. M., Burkhalter, J. E., & DuHamel, K. N. (2009) · Psycho-Oncology · doi:10.1002/pon.1399 · Cited by 315 · see citing works
Syrjala, K. L., Chapko, M. K., VITALIANO, P. P., Cummings, C. C., & Sullivan, K. M. (1993) · PubMed · Cited by 254 · see citing works
El‐Jawahri, A. R., Traeger, L. N., Kuzmuk, K., Eusebio, J. R., Vandusen, H. B., Shin, J. A., Keenan, T., Gallagher, E. R., Greer, J. A., Pirl, W. F., et al. (2015) · Cancer · doi:10.1002/cncr.29149 · Cited by 218 · see citing works
Self-citationValidation of the PTSD checklist–civilian version in survivors of bone marrow transplantation
Smith, M. Y., Redd, W. H., DuHamel, K. N., Vickberg, S. M. J., & Ricketts, P. (1999) · Journal of Traumatic Stress · doi:10.1023/a:1024719104351 · Cited by 213 · see citing works
Andrykowski, M. A., & Cordova, M. (1998) · Journal of Traumatic Stress · doi:10.1023/a:1024490718043 · Cited by 201 · see citing works
Widows, M. R., Jacobsen, P. B., & Fields, K. K. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200011000-00018 · Cited by 153 · see citing works
Kiss, T. L., Abdolell, M., Jamal, N., Minden, M. D., Lipton, J. H., & Messner, H. A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.06.077 · Cited by 147 · see citing works
Recovery After Stem-Cell Transplantation for Hematologic Diseases
Lee, S. J., Fairclough, D. L., Parsons, S. K., Soiffer, R. J., Fisher, D. C., Schlossman, R. L., Antin, J. H., & Weeks, J. C. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.1.242 · Cited by 145 · see citing works
Jacobsen, P. B., Sadler, I. J., Booth‐Jones, M., Soety, E. M., Weitzner, M. A., & Fields, K. K. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.70.1.235 · Cited by 144 · see citing works
Routine screening for psychosocial distress following hematopoietic stem cell transplantation
Lee, S. J., Loberiza, F. R., Antin, J. H., Kirkpatrick, T., Prokop, L. J., Alyea, E. P., Cutler, C. S., Ho, V. T., Richardson, P. G. G., Schlossman, R. L., et al. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704709 · Cited by 142 · see citing works
Posttraumatic distress symptoms in operable breast cancer III:
Tjemsland, L., Søreide, J. A., & Malt, U. F. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1005957302990 · Cited by 128 · see citing works
Jacobsen, P. B., Sadler, I. J., Booth‐Jones, M., et al. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.1.235 · Cited by 118 · see citing works
Symptoms and Quality of Life in Diverse Patients Undergoing Hematopoietic Stem Cell Transplantation
Cohen, M. Z., Rozmus, C., Mendoza, T. R., Padhye, N. S., Neumann, J. L., Gning, I., Aleman, A., Giralt, S. A., & Cleeland, C. S. (2012) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.08.011 · Cited by 116 · see citing works
Braamse, A. M. J., Gerrits, M. M. J. G., van Meijel, B., Visser, O., van Oppen, P., Boenink, A. D., Cuijpers, P., Huijgens, P. C., Beekman, A. T. F., & Dekker, J. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.130 · Cited by 101 · see citing works
Prieto, J. M., Atala, J., Blanch, J., Carreras, E., Rovira, M., Cirera, E., & Gastó, C. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704788 · Cited by 98 · see citing works
WOMEN'S EXPERIENCE OF TRAUMATIC STRESS IN CANCER TREATMENT
Hampton, M. (2000) · Health Care For Women International · doi:10.1080/073993300245410 · Cited by 84 · see citing works
Physicians' attitudes about quality-of-life issues in hematopoietic stem cell transplantation
Lee, S. J. (2004) · Blood · doi:10.1182/blood-2003-07-2430 · Cited by 73 · see citing works
Hefner, J., Kapp, M., Drebinger, K., Dannenmann, A., Einsele, H., Grigoleit, G.-U., Faller, H., Csef, H., & Mielke, S. (2014) · Bone Marrow Transplantation · doi:10.1038/bmt.2013.228 · Cited by 50 · see citing works
Díez‐Campelo, M., Pérez‐Simón, J. A., González‐Porras, J. R., García-Cecilia, J. M., Salinero, M., Caballero, M. D., Cañizo, M., Ocio, E. M., & Miguel, J. F. S. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704646 · Cited by 46 · see citing works
Survivorship: Fatigue, Version 1.2014
Denlinger, C. S., Ligibel, J. A., Are, M., Baker, K. S., Demark‐Wahnefried, W., Friedman, D. L., Goldman, M. E., Jones, L. W., King, A. A., Ku, G., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0082 · Cited by 29 · see citing works
Pillay, B., Lee, S. J., Katona, L., Burney, S., & Avery, S. (2013) · Psycho-Oncology · doi:10.1002/pon.3462 · Cited by 25 · see citing works
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Prevalence of post-traumatic stress disorder in the United States: a systematic literature review
Schein, J., Houle, C., Urganus, A., Cloutier, M., Patterson-Lomba, O., Wang, Y., King, S., Levinson, W., Guérin, A., Lefebvre, P., et al. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.1978417 · Cited by 288 · see citing works
Bevans, M., El-Jawahri, A., Tierney, D. K., Wiener, L., Wood, W. A., Hoodin, F., Kent, E. E., Jacobsen, P. B., Lee, S. J., Hsieh, M. M., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2016.09.011 · Cited by 166 · see citing works
“Post-Traumatic Stress—Few studies have examined prevalence and risk factors for posttraumatic stress disorder (PTSD) further than one year after HCT (61, 64).”
BackgroundSelf-citationMindfulness, Experiential Avoidance, and Recovery From Hematopoietic Stem Cell Transplantation.
Larson, A. G., Morris, K. J., Juckett, M. B., Coe, C. L., Broman, A. T., & Costanzo, E. S. (2019) · Annals of Behavioral Medicine · doi:10.1093/abm/kay097 · Cited by 27 · see citing works
Smith, S. K., Somers, T. J., Kuhn, E., Laber, E., Sung, A. D., Syrjala, K. L., Feger, B., Kelleher, S. A., Majestic, C., Gebert, R., et al. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106569 · Cited by 14 · see citing works
- Authors
- El‐Jawahri, A. R., Vandusen, H. B., Traeger, L. N., Fishbein, J. N., Keenan, T., Gallagher, E. R., Greer, J. A., Pirl, W. F., Jackson, V. A., Spitzer, T. R., Chen, Y. A., & Temel, J. S.
- Affiliations
- Bone Marrow Transplant Program Massachusetts General Hospital Boston Massachusetts
- Massachusetts General Hospital (US)
- ORCID
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2015-12-09
- Volume
- 122
- Issue
- 5
- Pages
- 806-812
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- PMC
- PMC4788001
- OpenAlex
- W2193100439
- Semantic Scholar
- 0aaf2adbdb07d44eb39437c6d3fe52343b370804
- Cited by
- 137
- References
- 33
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 6 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 5
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K24CA181253)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- post-traumatic stress disorder, hematopoietic stem cell transplantation, quality of life, depression, anxiety, mood, hospitalization, predictors of PTSD, autologous transplantation, allogeneic transplantation, FACT-BMT, PHQ-9, Hospital Anxiety and Depression Scale, PTSD Checklist, psychological distress in cancer patients, post-transplant mental health
- MeSH terms
- Adult, Affect, Aged, Anxiety, Depression, Female, Hospitalization, Humans, Leukemia, Longitudinal Studies, Lymphoma, Male, Middle Aged, Multiple Myeloma, Myelodysplastic Syndromes, Prospective Studies, Quality of Life, Stress Disorders, Post-Traumatic, Transplantation, Autologous, Transplantation, Homologous, Hematopoietic Stem Cell Transplantation, Hematologic Neoplasms, Primary Myelofibrosis
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