The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Targeting autophagy in cancer
Open accessAbstract
Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular homeostasis during stress conditions. Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. Early results from clinical trials that repurposed hydroxychloroquine for cancer have suggested that autophagy inhibition may be a promising approach for advanced cancers. In this review of the literature, the authors present fundamental advances in the biology of autophagy, approaches to targeting autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role of autophagy in tumor immunity, and recent developments in next‐generation autophagy inhibitors that have clinical potential. Autophagy is a promising target for drug development in cancer. Cancer 2018. © 2018 American Cancer Society .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y.-J., Jiang, Q., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,304
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,539
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311
The machinery of macroautophagy
Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gélinas, C., Fan, Y., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.001 · Cited by 2,011
Deconvoluting the context-dependent role for autophagy in cancer
White, E. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3262 · Cited by 1,704
Network organization of the human autophagy system
Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature · doi:10.1038/nature09204 · Cited by 1,554
Immunological effects of conventional chemotherapy and targeted anticancer agents
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.10.012 · Cited by 1,530
Pancreatic cancers require autophagy for tumor growth
Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J. M., Dell'Antonio, G., et al. (2011) · Genes & Development · doi:10.1101/gad.2016111 · Cited by 1,498
Research works printed but not linked: 5
- Borowa‐Mazgaj B, 2016, Antitumor DNA‐damaging C‐1748 is a new inhibitor of autophagy that triggers apoptosis in human pancreatic cancer cell lines, FASEB J, 30, 1062, 10.1096/fasebj.30.1_supplement.1062.5 · doi:10.1096/fasebj.30.1_supplement.1062.5
- 10.1080/15548627.2017.1280222 · doi:10.1080/15548627.2017.1280222
- 10.1200/JCO.2017.35.15_suppl.3545 · doi:10.1200/jco.2017.35.15_suppl.3545
- Miller‐Ocuin JL, 2017, Inhibition of autophagy improves pathologic and biomarker response to preoperative gemcitabine/nab‐paclitaxel in potentially resectable pancreatic cancer: A phase II randomized controlled trial [abstract], Society of Surgical Oncology Annual Cancer Symposium, 3
- Gangahdar T, 2017, High response rates with combined BRAF and autophagy inhibition: results of 2 phase I trials, Pigment Cell Melanoma Res
Cited by
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Bahar, M. E., Kim, H. J., & Kim, D. R. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01705-z · Cited by 888
Drug Resistance in Colorectal Cancer: From Mechanism to Clinic
Wang, Q., Shen, X., Chen, G., & Du, J. (2022) · Cancers · doi:10.3390/cancers14122928 · Cited by 160
Panda, P. K., Fahrner, A., Vats, S., Seranova, E., Sharma, V., Chipara, M., Desai, P., Torresi, J., Rosenstock, T., Kumar, D., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00038 · Cited by 50
Shen, P.-W., Chou, Y.-M., Li, C.-L., Liao, E.-C., Huang, H.-S., Yin, C.-H., Chen, C.-L., & Yu, S.-J. (2021) · Oncology Letters · doi:10.3892/ol.2021.13029 · Cited by 23
Langer, R., Neppl, C., Keller, M. D., Schmid, R. A., Tschan, M. P., & Berezowska, S. (2018) · Cancers · doi:10.3390/cancers10090281 · Cited by 17
Metadata
- Authors
- Onorati, A. V., Dyczynski, M., Ojha, R., & Amaravadi, R. K.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2018-04-19
- Volume
- 124
- Issue
- 16
- Pages
- 3307-3318
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2800819803
- Cited by
- 837
- References
- 101
- FWCI
- 53.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- Funders
- National Institutes of Health (R01CA169134)
- National Cancer Institute (R01CA198015)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Targeting autophagy in cancer. https://app.cochat.ai/papers/10.1002/cncr.31335
- The paper
- Onorati, A. V., Dyczynski, M., Ojha, R., & Amaravadi, R. K. (2018). Targeting autophagy in cancer. Cancer. https://doi.org/10.1002/cncr.31335
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
