The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A randomized, double‐blind, placebo‐controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma
Abstract
Background: The objective of this study was to evaluate the effect of a probiotic combination on the severity of oral mucositis (OM), which is a common, unpreventable complication induced by radiochemotherapy in patients with nasopharyngeal carcinoma who undergo concurrent radiochemotherapy (CCRT). Methods: Eligible patients (n = 99) with locally advanced nasopharyngeal carcinoma who were undergoing CCRT were randomly assigned (2:1) to receive a probiotic combination or placebo during radiochemotherapy, and the incidence of severe OM (grade 3 or higher) was the primary endpoint. Results: Patients taking the probiotic combination showed a significant reduction in the severity of OM. The incidences of grade 0, 1, 2, and 3 OM in the placebo group and the probiotic combination group were 0% and 12.07%, 0% and 55.17%, 54.29% and 17.24%, and 45.71% and 15.52%, respectively. Furthermore, CCRT greatly lowered the number of immune cells, whereas the probiotic combination markedly lowered the reduction rates of CD4 + T cells (76.59% vs 52.85%; P < .05), CD8 + T cells (62.94% vs 29.76%; P < .05), and CD3 + T cells (69.72% vs 45.49%; P < .05) in an A‐CCRT‐P (after treatment with radiotherapy plus chemotherapy plus the probiotic combination) group. High‐throughput sequencing results indicated that CCRT had obviously disturbed the intestinal diversity of patients in an A‐CCRT (after treatment with radiotherapy plus chemotherapy plus a placebo) group, whereas the probiotic combination distinctly restored the microbial diversity in the A‐CCRT‐P group toward that of healthy people and a B‐CCRT‐P (before the treatment of radiotherapy plus chemotherapy plus the probiotic combination) group. Conclusions: A probiotic combination significantly enhances the immune response of patients and reduces the severity of OM through modification of gut microbiota.
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Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
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Reciprocal interactions of the intestinal microbiota and immune system
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“There is evidence that Bacteroidales and Bifidobacterium greatly increase the number and activity of immune cells, which then promote the efficacy of anti–cytotoxic T lymphocyte–associated protein 4 and anti–programmed death ligand 1 therapy.(9,13) For”
BackgroundDevelopment of immuno-oncology drugs — from CTLA4 to PD1 to the next generations
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Antibiotics for cancer treatment: A double-edged sword
Gao, Y., Shang, Q., Li, W., Guo, W., Stojadinovic, A., Mannion, C., Man, Y.-G., & Chen, T. (2020) · Journal of Cancer · doi:10.7150/jca.47470 · Cited by 253
Self-citationThe impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies
Guo, C., Kong, L., Xiao, L., Liu, K., Cui, H., Xin, Q., Gu, X., Jiang, C., & Wu, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01135-y · Cited by 48
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Metadata
- Authors
- Jiang, C., Wang, H., Xia, C., Dong, Q., Chen, E., Qiu, Y., Su, Y., Xie, H., Zeng, L., Kuang, J., Ao, F., Gong, X., Li, J., & Chen, T.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2018-12-06
- Volume
- 125
- Issue
- 7
- Pages
- 1081-1090
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2904414943
- Cited by
- 188
- References
- 6
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jiang, C., Wang, H., Xia, C., Dong, Q., Chen, E., Qiu, Y., Su, Y., Xie, H., Zeng, L., Kuang, J., Ao, F., Gong, X., Li, J., & Chen, T. (2019). A randomized, double‐blind, placebo‐controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma. Cancer. https://doi.org/10.1002/cncr.31907
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