Cytopathology of pediatric malignancies: Where are we today with fine‐needle aspiration biopsies in pediatric oncology?
Open accessAbstract
Pediatric malignancies are uncommon and many have overlapping morphologic features, which together present diagnostic challenges. Cytopathology is recognized as an accurate and cost‐effective modality for the diagnosis of pediatric malignancies in resource‐limited countries, but is underused for this purpose in the United States. This review focuses on the cytopathology of pediatric malignancies with the goal of demystifying cytologic diagnoses of these entities. Differences between malignancies in young patients and adults are discussed, and key epidemiological features of childhood malignancies are highlighted. In addition, the use of cytopathology in different geographical settings is contrasted to illustrate the impact of variable usage on the incidence of malignancy and the types of tumors observed in cytologic specimens. A review of the pattern‐based approach to differential diagnosis is also incorporated, including the cytomorphologic features and ancillary studies that help to distinguish between various malignancies within each pattern. Cancer (Cancer Cytopathol) 2014;122:322–336. © 2014 American Cancer Society.
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FNAC is a safe, accurate, prompt and inexpensive procedure for diagnosis of both neoplastic and infectious diseases in adult and pediatric populations.
“Fine needle aspiration cytology (FNAC) has been widely accepted to be a safe, accurate, prompt and inexpensive procedure for diagnosis of both neoplastic and infectious diseases in adult and pediatric populations.”
From Utilization of fine needle aspiration cytology at Kamuzu central hospital (2018) · cites this paper as [12]
The Introduction and Conclusions (page unavailable) describe FNAB as accurate, less costly, and less invasive for diagnosing pediatric malignancies. The section on pediatric cytopathology in different practice settings says cytology can quickly diagnose infectious diseases in resource-limited areas. The paper does not establish these qualities for adults, and it says FNAB remains underused for pediatric malignancies in the United States, rather than being widely accepted across settings. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFNAC provides a definitive tissue diagnosis to fill in the gap for many diagnostic dilemmas especially when used in conjunction with cell block and IHC studies.
“FNAC provides a definitive tissue diagnosis to fill in the gap for many diagnostic dilemmas[8–12] especially when used in conjunction with cell block and IHC studies.”
From Utilization of fine needle aspiration cytology at Kamuzu central hospital (2018) · cites this paper as [12]
The Clear Cell Pattern section (page unavailable) says a specific cytologic diagnosis is often possible with ancillary studies including IHC, supporting the central point. But the paper addresses pediatric malignancies, does not present cell blocks as a general solution, and cautions in Pitfalls and Limitations (page unavailable) that FNAB cannot always provide a definitive classification. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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Cites
International Classification of Childhood Cancer, third edition
Steliarova‐Foucher, E., Stiller, C. A., Lacour, B., & Kaatsch, P. (2005) · Cancer · doi:10.1002/cncr.20910 · Cited by 1,554 · see citing works
Steliarova‐Foucher, E., Stiller, C. A., Kaatsch, P., Berrino, F., Coebergh, J. W. W., Lacour, B., & Perkin, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17550-8 · Cited by 562 · see citing works
Paediatric cancer in low-income and middle-income countries
Magrath, I., Steliarova-Foucher, E., Epelman, S., Ribeiro, R. C., Harif, M., Li, C.-K., Kebudi, R., Macfarlane, S. D., & Howard, S. C. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70008-1 · Cited by 422 · see citing works
O’Leary, M., Krailo, M., Anderson, J. R., & Reaman, G. H. (2008) · Seminars in Oncology · doi:10.1053/j.seminoncol.2008.07.008 · Cited by 294 · see citing works
Langerhans cell histiocytosis: Current concepts and treatments
Abla, O., Egeler, R. M., & Weitzman, S. S. (2010) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2010.02.012 · Cited by 274 · see citing works
Kanagal‐Shamanna, R., Portier, B. P., Singh, R. R., Routbort, M. J., Aldape, K., Handal, B. A., Rahimi, H., Reddy, N. G., Barkoh, B. A., Mishra, B. M., et al. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.122 · Cited by 215 · see citing works
Uncommon and recently described renal carcinomas
Srigley, J. R., & Delahunt, B. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.70 · Cited by 210 · see citing works
Cancer in children and adolescents in Europe: Developments over 20 years and future challenges
Pritchard‐Jones, K., Kaatsch, P., Steliarova‐Foucher, E., Stiller, C. A., & Coebergh, J. W. W. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.06.006 · Cited by 195 · see citing works
Current management of Wilms’ tumor in children
Ko, E., & Ritchey, M. L. (2008) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2008.08.007 · Cited by 142 · see citing works
Multiple endocrine neoplasia type 2
Nelson Wohllk, G., Schweizer, H., Erlic, Z., Schmid, K. W., Walz, M. K., Raue, F., & Neumann, H. P. H. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.02.001 · Cited by 137 · see citing works
New policies to address the global burden of childhood cancers
Sullivan, R., Kowalczyk, J. R., Agarwal, B., Ladenstein, R., Fitzgerald, E., Barr, R., Steliarova-Foucher, E., Magrath, I., Howard, S. C., Kruger, M., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70007-x · Cited by 121 · see citing works
Renal Cell Carcinoma Associated With Transcription Factor E3 Expression and Xp11.2 Translocation
Klatte, T., Streubel, B., Wrba, F., Mesut Remzi, A., Krammer, B. E., de Martino, M., Waldert, M., Marberger, M., Susani, M., & Haitel, A. (2012) · American Journal of Clinical Pathology · doi:10.1309/ajcpq6llfmc4oxgc · Cited by 90 · see citing works
Fine needle aspiration biopsy: Role in diagnosis of pediatric head and neck masses
Anne, S., Teot, L. A., & Mandell, D. L. (2008) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2008.07.009 · Cited by 71 · see citing works
Self-citationPediatric Fine-Needle Aspiration Biopsy
Silverman, J. F., Gurley, A. M., Holbrook, C. T., & Joshi, V. V. (1991) · American Journal of Clinical Pathology · doi:10.1093/ajcp/95.5.653 · Cited by 53 · see citing works
Lymphadenopathy in children and adolescents: role of fine-needle aspiration in management.
Ponder, T. B., Smith, D., & Ramzy, I. (2000) · PubMed · Cited by 44 · see citing works
The use of fine-needle aspiration biopsy in children
Cohen, M. B., Bottles, K., Ablin, A. R., & Miller, T. R. (1990) · American Journal of Otolaryngology · doi:10.1016/0196-0709(90)90181-t · Cited by 44 · see citing works
Fine Needle Aspiration Cytology of Hepatoblastoma
Iyer, V. K., Kapila, K., Agarwala, S., & Verma, K. (2005) · Acta Cytologica · doi:10.1159/000326166 · Cited by 38 · see citing works
Up-to-date survival curves of children with cancer by period analysis
Brenner, H. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600947 · Cited by 32 · see citing works
Fine-Needle Aspiration Biopsy in Pediatric Oncology Patients
Drut, R., Drut, R. M., Pollono, D. G., Tomarchio, S., Ibáñez, O., Urrutia, A., & Ripoll, M. (2005) · Journal of Pediatric Hematology/Oncology · doi:10.1097/01.mph.0000173177.40894.8d · Cited by 25 · see citing works
Razack, R., Michelow, P., Leiman, G., Harnekar, A., Poole, J., Wessels, G., Hesseling, P., Stefan, C., Louw, M., Schubert, P. T., et al. (2012) · Diagnostic Cytopathology · doi:10.1002/dc.21624 · Cited by 25 · see citing works
In situ telomerase activity in pleural effusions: A promising marker for malignancy
Dejmek, A., Yahata, N., Ohyashiki, K., Ebihara, Y., Kakihana, M., Hirano, T., Kawate, N., & Kato, H. (2000) · Diagnostic Cytopathology · doi:10.1002/1097-0339(200101)24:1 · Cited by 24 · see citing works
Fine‐needle aspiration biopsy in children: Experience in 70 cases
Verdeguer, A., Castel, V., Torres, V., Olagüe, R., Ferrís, J., Esquembre, C., Vallcanera, A., & Muro, M. D. (1988) · Medical and Pediatric Oncology · doi:10.1002/mpo.2950160206 · Cited by 24 · see citing works
Fine needle aspiration biopsy cytology of hepatoblastoma.
Wakely, P. E., Silverman, J. F., Kr, G., & Wj, F. (1990) · PubMed · Cited by 23 · see citing works
Boonyaarunnate, T., Olson, M. T., Bishop, J. A., Yang, G. C. H., & Ali, S. Z. (2013) · Acta Cytologica · doi:10.1159/000345879 · Cited by 22 · see citing works
The cytology of pediatric masses: A differential diagnostic approach
Howell, L. P., Russell, L. A., Howard, P. H., & Teplitz, R. L. (1992) · Diagnostic Cytopathology · doi:10.1002/dc.2840080204 · Cited by 17 · see citing works
Viswanathan, S., George, S. M., Ramadwar, M. R., Medhi, S. S., Arora, B., & Kurkure, P. A. (2009) · Diagnostic Cytopathology · doi:10.1002/dc.21143 · Cited by 15 · see citing works
Hepatoblastoma—An attempt of histological subtyping on fine‐needle aspiration material
Barwad, A. W., Gupta, N., Gupta, K., Rajwanshi, A., Marwaha, R. K., Rao, K. L. N., Dey, P., Srinivasan, R., & Nijhawan, R. (2012) · Diagnostic Cytopathology · doi:10.1002/dc.21772 · Cited by 13 · see citing works
Pediatric cancer in low-income and middle-income countries
MAGRATH, I. T., Steliarova‐Foucher, E., Epelman, S., Ribeiro, R. C., Harif, M., Li, C. K., Kebudi, R., Macfarlane, S., & Howard, S. C. (2013) · Cited by 12 · see citing works
Fine-needle aspiration cytopathology in the diagnosis of Wilms tumor
Fernández-Pineda, I., Cabello, R., García-Cantón, J. A., Pérez‐Bertólez, S., Limousín, I. T., Ramirez, G. L., Márquez-Vega, C., & de Agustín, J. C. (2011) · Clinical & Translational Oncology · doi:10.1007/s12094-011-0738-2 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [15]15. Howell LP. Changing role of fine-needle aspiration on the evalua- tion of pediatric masses. Diagn Cytopathol. 2001;24:65-70.
Cited by
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Ronchi, A., Caputo, A., Pagliuca, F., Montella, M., Marino, F. Z., Zeppa, P., Franco, R., & Cozzolino, I. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153294 · Cited by 19 · see citing works
Intraductal papilloma of the breast in an 11-year-old male patient: a case report
Tsilimigras, D. I., Ntanasis‐Stathopoulos, I., Bakopoulos, A., Schizas, D., Kalfa, M., Karyda, I., Papaioannou, D., Klapsinou, E., Salla, C., Sergentanis, T. Ν., et al. (2017) · Pediatric Surgery International · doi:10.1007/s00383-017-4081-8 · Cited by 8 · see citing works
Utilization of Flow Cytometry in Pediatric Fine-Needle Aspiration Biopsy Specimens
Silowash, R., Pantanowitz, L., Craig, F. E., Simons, J. P., & Monaco, S. E. (2016) · Acta Cytologica · doi:10.1159/000448510 · Cited by 7 · see citing works
Self-citationUtilization of fine needle aspiration cytology at Kamuzu central hospital
Khan, S., Liomba, G., Rosenberg, N. E., Stanley, C., Kampani, C., Dhungel, B. M., & Hosseinipour, M. C. (2018) · PLOS ONE · doi:10.1371/journal.pone.0196561 · Cited by 4 · see citing works
Laboratory Techniques Used in the Diagnosis of Pediatric Tumors
Hoehn, D., & Loghavi, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1729-7_1
Small Cell Variant of Renal Oncocytoma – a Case Report of Unusual Histopathologic Entity
Bartoš, V. (2017) · Galician Medical Journal · doi:10.21802/gmj.2017.3.3
Molecular Cytology Applications in Soft Tissue
Dantey, K. E., & Monaco, S. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-74942-6_12
Self-citationMolecular Diagnostics in Pediatric Cytopathology
Fuller, M. Y., & Monaco, S. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-97397-5_19
Self-citationMonaco, S. E., & Teot, L. A. (2017) · Springer eBooks · doi:10.1007/978-3-662-53441-0_1
Self-citationMonaco, S. E. (2017) · Springer eBooks · doi:10.1007/978-3-662-53441-0_3
Self-citationInternational perspective on pediatric cytology
Fuller, M. Y., Shrestha, S., & Baskota, S. U. (2024) · Cancer Cytopathology · doi:10.1002/cncy.22911
Special Issue: Cytopathology in Pediatrics
Xavier‐Júnior, J. C. C., & Saieg, M. A. (2025) · Acta Cytologica · doi:10.1159/000549665
- Authors
- Monaco, S. E., & Teot, L. A.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Teot, Lisa A.
- ORCID
- Monaco, Sara E.
- Venue
- Cancer Cytopathology
- Publisher
- Wiley
- Published
- 2014-03-06
- Volume
- 122
- Issue
- 5
- Pages
- 322-336
- ISSN
- 1934-662X (ISSN-L)
- 1934-6638
- OpenAlex
- W2132304562
- Cited by
- 12
- References
- 29
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2018: 3 · 2017: 4 · 2016: 1 · 2014: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Cytopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Keywords
- pediatric malignancies, fine needle aspiration cytology, cytopathology, differential diagnosis, cytomorphologic features, childhood cancer epidemiology, resource-limited settings, ancillary studies
- MeSH terms
- Adult, Child, Cytodiagnosis, Humans, Neoplasms, Biopsy, Fine-Needle
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