The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Axonal projections of pulmonary slowly adapting receptor relay neurons in the rat.
Abstract
We elucidated efferent projections of second‐order relay neurons (P‐cells) activated by afferents originating from slowly adapting pulmonary receptors (SARs) to determine the central pathway of the SAR‐evoked reflexes. Special attention was paid to visualizing the P‐cell projections within the nucleus tractus solitarii (NTS), which may correspond to the inhibitory pathway from P‐cells to second‐order relay neurons (RAR‐cells) of rapidly adapting pulmonary receptors. P‐cells were recorded from the NTS in Nembutal‐anesthetized, paralyzed, and artificially ventilated rats. First, we used electrophysiological methods of antidromic mapping and showed that the majority of the P‐cells examined projected their axons to the caudal NTS and to the dorsolateral pons corresponding to the parabrachial complex. Second, a mixture of HRP and Neurobiotin was injected intracellularly or juxtramembranously into P‐cells. (1) Stained P‐cells (n = 7) were located laterally to the solitary tract and had dendrites extending characteristically along the lateral border of the solitary tract. (2) All P‐cells had stem axons projecting to the ipsilateral medulla. Of these, the axons from five P‐cells projected to the nucleus ambiguus and its vicinity with distributing boutons. Some of these axons further ascended in the ventrolateral medulla, and distributed boutons in the areas ventral or ventrolateral to the nucleus ambiguus. (3) All the P‐cells had axonal branches with boutons in the NTS area. In particular, axons from three P‐cells projected bilaterally to the medial NTS caudal to the obex, i.e., to the area of RAR‐cells. These results show anatomic substrates for the connections implicated in the P‐cell inhibition of RAR‐cells as well as the SAR‐induced respiratory reflexes. J. Comp. Neurol. 446:81–94, 2002. © 2002 Wiley‐Liss, Inc.
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“These afferents project to discrete areas in the brainstem within the nucleus of the solitary tract (NTS) and initiate inhibitory actions on downstream targets.”
From Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation (2019) · cites this paper as Ezure et al., 2002
In the citing paper
“In contrast, SARs act on second-order ventrolateral NTS neurons to directly or indirectly inhibit cardioinhibitory neurons of the nucleus ambiguus (Stuesse and Fish, 1984; Neff et al., 1998; Ezure et al., 2002).”
From Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation (2019) · cites this paper as Ezure et al., 2002
Citations
Cites
Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in Mammals
Smith, J. C., Ellenberger, H. H., Ballanyi, K., Richter, D. W., & Feldman, J. L. (1991) · Science · doi:10.1126/science.1683005 · Cited by 2,179
Bianchi, A. L., Denavit‐Saubié, M., & Champagnat, J. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.1 · Cited by 922
Pinault, D. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00144-1 · Cited by 720
Bieger, D., & Hopkins, D. A. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902620408 · Cited by 547
Neurogenesis of respiratory rhythm in the mammal
Cohen, M. I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.1105 · Cited by 538
Berger, A. J. (1977) · Brain Research · doi:10.1016/0006-8993(77)91028-9 · Cited by 227
Iscoe, S. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00046-x · Cited by 218
Pacemaker behavior of respiratory neurons in medullary slices from neonatal rat
Johnson, S. M., Smith, J. C., Funk, G. D., & Feldman, J. L. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.6.2598 · Cited by 194
Bonham, A. C., & McCrimmon, D. R. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018171 · Cited by 172
Distribution of medullary respiratory neurons in the rat
Ezure, K., Manabe, M., & Yamada, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)90085-6 · Cited by 164
Self-citation
Research works printed but not linked: 4
- Anders K, 1987, Morphology of medullary pump‐neurones of cats, Pflugers Arch, 408, R54
- Duffin J, 1995, Respiratory rhythm generation: focus on the rostral ventrolateral medulla, News Physiol Sci, 10, 133
- Hayashi F, 1998, Axonal projection patterns of pump cells within the medulla, Jpn J Physiol, 48, S80
- Kubin L, 1980, Properties of the rostral NRA expiratory neurones projecting to the contralateral NTS group, Neurosci Lett, 5, S141
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Vagal Afferent Innervation of the Airways in Health and Disease
Mazzone, S. B., & Undem, B. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00039.2015 · Cited by 562
Central pathways of pulmonary and lower airway vagal afferents.
Kubin, L., Alheid, G. F., Zuperku, E. J., & McCrimmon, D. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00252.2006 · Cited by 477
Saper, C. B., & Stornetta, R. L. (2004) · Elsevier eBooks · doi:10.1016/b978-0-12-374245-2.00023-1 · Cited by 325
The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities
Zoccal, D. B., Furuya, W. I., Bassi, M., Colombari, D. S. A., & Colombari, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00238 · Cited by 265
The chemical neuroanatomy of breathing
Alheid, G. F., & McCrimmon, D. R. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.07.014 · Cited by 207
Metadata
- Authors
- Ezure, K., Tanaka, I., Saito, Y., & Otake, K.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Ezure, Kazuhisa
- ORCID
- Saito, Yoshiaki
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2002-03-19
- Volume
- 446
- Issue
- 1
- Pages
- 81-94
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2086248309
- Cited by
- 76
- References
- 40
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2020: 2 · 2019: 5 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- P cells, nucleus tractus solitarius, axonal projections, parabrachial complex, nucleus ambiguus, ventrolateral medulla, respiratory reflexes, central pathways, rats
- MeSH terms
- Action Potentials, Animals, Axons, Bronchi, Dendrites, Mechanoreceptors, Nerve Net, Neural Conduction, Neural Inhibition, Pons, Reaction Time, Respiratory Center, Vagus Nerve, Rats, Wistar, Solitary Nucleus, Presynaptic Terminals, Visceral Afferents, Cell Size, Rats
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