Comprehensive classification of the auditory sensory projections in the brain of the fruit fly Drosophila melanogaster
Abstract
We established a comprehensive projection map of the auditory receptor cells (Johnston's organ neurons: JONs) from the antennae to the primary auditory center of the Drosophila brain. We found 477 ± 24 cell bodies of JONs, which are arranged like a “bottomless bowl” within the auditory organ. The target of the JONs in the brain comprises five spatially segregated zones, each of which is contributed by bundles of JON axons that gradually branch out from the antennal nerve. Four zones are confined in the antennal mechanosensory and motor center, whereas one zone further extends over parts of the ventrolateral protocerebrum and the subesophageal ganglion. Single‐cell labeling with the FLP‐out technique revealed that most JONs innervate only a single zone, indicating that JONs can be categorized into five groups according to their target zones. Within each zone, JONs innervate various combinations of subareas. We classified these five zones into 19 subareas according to the branching patterns and terminal distributions of single JON axons. The groups of JONs that innervate particular zones or subareas of the primary auditory center have their cell bodies in characteristic locations of the Johnston's organ in the antenna, e.g., in concentric rings or in paired clusters. Such structural organization suggests that each JON group, and hence each zone of the primary auditory center, might sense different aspects of sensory signals. J. Comp. Neurol. 499:317–356, 2006. © 2006 Wiley‐Liss, Inc.
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The precise target zones in the antennal mechanosensory and motor center of some auditory receptor neurons (Johnston's organ neurons) were not determined because of insufficient information in the hemibrain image volume.
“Some of the auditory receptor neurons (Johnston’s organ neurons) were also identified, but their precise target zones in the antennal mechanosensory and motor center (Kamikouchi et al., 2006) were not determined because of the insufficient information in the hemibrain image volume.”
From A connectome and analysis of the adult Drosophila central brain (2020) · cites this paper as Kamikouchi et al., 2006
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- Authors
- Kamikouchi, A., Shimada, T., & Ito, K.
- Affiliations
- Japan Science and Technology Agency (JP)
- Corresponding author
- Kamikouchi, Azusa
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2006-09-22
- Volume
- 499
- Issue
- 3
- Pages
- 317-356
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2050115159
- Cited by
- 220
- References
- 3
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 21 · 2022: 8 · 2021: 10 · 2020: 14 · 2019: 4 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 10 · 2014: 15 · 2013: 21 · 2012: 12
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- Johnston's organ, Drosophila melanogaster, projection map, suboesophageal ganglion, antennal nerve
- MeSH terms
- Animals, Auditory Pathways, Axons, Brain, Brain Mapping, Drosophila melanogaster, Female, Hearing, Mechanoreceptors, Neurons, Afferent, Sensory Receptor Cells, Species Specificity, Staining and Labeling, Presynaptic Terminals, Ganglia, Invertebrate, Gravity Sensing, Mechanotransduction, Cellular
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