Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

Eichler, Katharina; Hampel, Stefanie; Alejandro-García, Adrián; Calle-Schuler, Steven A.; Santana-Cruz, Alexis; Kmecova, Lucia; Blagburn, Jonathan M.; Hoopfer, Eric D.; Seeds, Andrew M.

doi:10.7554/elife.87602.1

PreprintCited by 1Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchTactile and Sensory Interactions

Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

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Eichler, Katharina, Hampel, Stefanie, Alejandro-García, Adrián, Calle-Schuler, Steven A., Santana-Cruz, Alexis, Kmecova, Lucia, Blagburn, Jonathan M., Hoopfer, Eric D. +1 more·2023·eLife

DOI 10.7554/elife.87602.1

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Abstract

Abstract Mechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behaviors remains unclear. We previously discovered that Drosophila perform a body location-prioritized grooming sequence when mechanosensory neurons at different locations on the head and body are simultaneously stimulated by dust (Hampel et al., 2017; Seeds et al., 2014). Here, we identify nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations, while collectively eliciting a whole head grooming sequence. Different tracing methods were used to reconstruct the projections of these neurons from different locations on the head to their distinct arborizations in the brain. This provides the first synaptic resolution somatotopic map of a head, and defines the parallel-projecting mechanosensory pathways that elicit head grooming.

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Previous studies have identified almost all head mechanosensory bristle and taste peg mechanosensory neurons in the left hemisphere.
“Previous studies have identified almost all head mechanosensory bristle and taste peg mechanosensory neurons102 in the left hemisphere (at the time of publication: right hemisphere).”
From Whole-brain annotation and multi-connectome cell typing of Drosophila (2024) · cites this paper as [102]

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Convergence of distinct subpopulations of mechanosensory neurons onto a neural circuit that elicits groomingPreprint
Hampel, S., Eichler, K., Yamada, D., Kim, H., Horigome, M., Franconville, R., Bock, D. D., Kamikouchi, A., & Seeds, A. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.08.141341 · Cited by 11 · see citing works
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Whole-brain annotation and multi-connectome cell typing of Drosophila
Schlegel, P., Yin, Y., Bates, A. S., Dorkenwald, S., Eichler, K., Brooks, P., Han, D. S., Gkantia, M., dos Santos, M., Munnelly, E. J., et al. (2024) · Nature · doi:10.1038/s41586-024-07686-5 · Cited by 413 · see citing works
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A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head
Calle-Schuler, S. A., Santana-Cruz, A., Kmecová, L., Hampel, S., & Seeds, A. M. (2026) · eLife · doi:10.7554/elife.108044.3 · Cited by 4 · see citing works
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Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila
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Mechanosensory and command contributions to the Drosophila grooming sequence
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Sensory inputs to Drosophila sequential grooming
Zhang, N. (2021) · eScholarship (California Digital Library)
A central somatotopic map of the fly leg supports spatially targeted grooming
Elabbady, L., Chou, G. M., Sustar, A., Cook, A., Collman, F., & Tuthill, J. C. (2026) · Current Biology · doi:10.1016/j.cub.2026.03.045 · Cited by 1 · see citing works

Authors: Eichler, K., Hampel, S., Alejandro-García, A., Calle-Schuler, S. A., Santana-Cruz, A., Kmecova, L., Blagburn, J. M., Hoopfer, E. D., & Seeds, A. M.
Affiliations: University of Puerto Rico, Medical Sciences Campus (PR)
ORCID: Eichler, Katharina
Hampel, Stefanie
Calle-Schuler, Steven A.
Santana-Cruz, Alexis
Blagburn, Jonathan M.
Hoopfer, Eric D.
Seeds, Andrew M.
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2023-05-31
ISSN: 2050-084X (ISSN-L)
DOI: 10.7554/elife.87602.1
OpenAlex: W4378837415
Cited by: 1
References: 107
Citations by year: 2024: 1
Type: posted content
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: eLife (acceptedVersion, cc-by)
Funders: BRAIN Initiative (1RF1NS121911-01)
Puerto Rico Science, Technology and Research Trust (2020-00195)
Whitehall Foundation (2017-12-69)
National Institute on Minority Health and Health Disparities (MD007600)
National Institute of General Medical Sciences (R25GM061838, 5R25GM061151, GM103642)
National Science Foundation (HRD-1736019)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: somatotopic map, mechanosensory neurons, grooming, Drosophila, parallel sensory pathways, arborization, tactile stimuli, body location

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Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

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