The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase‐1 transgenic mice: Mechanisms of mitochondriopathy and cell death
Abstract
The mechanisms of human mutant superoxide dismutase‐1 (mSOD1) toxicity to motor neurons (MNs) are unresolved. We show that MNs in G93A‐mSOD1 transgenic mice undergo slow degeneration lacking similarity to apoptosis structurally and biochemically. It is characterized by somal and mitochondrial swelling and formation of DNA single‐strand breaks prior to double‐strand breaks occurring in nuclear and mitochondrial DNA. p53 and p73 are activated in degenerating MNs, but without nuclear import. The MN death is independent of activation of caspases‐1, ‐3, and ‐8 or apoptosis‐inducing factor within MNs, with a blockade of apoptosis possibly mediated by Aven up‐regulation. MN swelling is associated with compromised Na,K‐ATPase activity and aggregation. mSOD1 mouse MNs accumulate mitochondria from the axon terminals and generate higher levels of superoxide, nitric oxide, and peroxynitrite than MNs in control mice. Nitrated and aggregated cytochrome c oxidase subunit‐I and α‐synuclein as well as nitrated SOD2 accumulate in mSOD1 mouse spinal cord. Mitochondria in mSOD1 mouse MNs accumulate NADPH diaphorase and inducible nitric oxide synthase (iNOS)‐like immunoreactivity, and iNOS gene deletion extends significantly the life span of G93A‐mSOD1 mice. Prior to MN loss, spinal interneurons degenerate. These results identify novel mechanisms for mitochondriopathy and MN degeneration in amyotrophic lateral sclerosis (ALS) mice involving blockade of apoptosis, accumulation of MN mitochondria with enhanced toxic potential from distal terminals, NOS localization in MN mitochondria and peroxynitrite damage, and early degeneration of α‐synuclein+ interneurons. The data support roles for oxidative stress, protein nitration and aggregation, and excitotoxicity as participants in the process of MN degeneration caused by mSOD1. J. Comp. Neurol. 500:20–46, 2007. © 2006 Wiley‐Liss, Inc.
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Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
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Cited by
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
Philips, T., & Robberecht, W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70015-1 · Cited by 646
Lithium delays progression of amyotrophic lateral sclerosis
Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M. L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708022105 · Cited by 550
Nitric oxide and neuronal death
Brown, G. C. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.06.001 · Cited by 393
Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation
Chestnut, B. A., Chang, Q., Price, A., Lesuisse, C., Wong, M., & Martin, L. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1639-11.2011 · Cited by 362
Self-citation
Metadata
- Authors
- Martin, L. J., Liu, Z., Chen, K., Price, A. C., Pan, Y., Swaby, J. A., & Golden, W. C.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2006-11-10
- Volume
- 500
- Issue
- 1
- Pages
- 20-46
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1972260106
- Cited by
- 269
- References
- 116
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Martin, L. J., Liu, Z., Chen, K., Price, A. C., Pan, Y., Swaby, J. A., & Golden, W. C. (2007). Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase‐1 transgenic mice: Mechanisms of mitochondriopathy and cell death. Journal of Comparative Neurology. https://doi.org/10.1002/cne.21160
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