Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

Philips, Thomas; Robberecht, Wim

doi:10.1016/s1474-4422(11)70015-1

Cited by 652Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury Research

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Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

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Philips, Thomas, Robberecht, Wim·2011·The Lancet Neurology

DOI 10.1016/s1474-4422(11)70015-1

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Abstract

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. In transgenic mouse models of mutant SOD1-associated familial ALS, reactive microglial cells and astrocytes actively contribute to the death of motor neurons. The biological processes that drive this glial reaction are complex and have both beneficial and deleterious effects on motor neurons. Therapeutic interventions targeting these cells are being explored. An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction.

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Activation of microglia through genetic, infectious, inflammatory, or physical stimuli leads to stereotypical changes in their morphology, accompanied by proliferation, migration, and the release of proinflammatory cytokines and chemokines.
“Activation of microglia through genetic, infectious, inflammatory, or physical stimuli, leads to stereotypical changes in their morphology, accompanied by proliferation, migration, and the release of proinflammatory cytokines and chemokines [417–419].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [419]

The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,676
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
Rothstein, J. D., Van Kammen, M., Levey, A. I., Martin, L. J., & Kuncl, R. W. (1995) · Annals of Neurology · doi:10.1002/ana.410380114 · Cited by 1,471
ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions
Bruijn, L. I., Becher, M. W., Lee, M. K., Anderson, K. L., Jenkins, N. A., Copeland, N. G., Sisodia, S. S., Rothstein, J. D., Borchelt, D. R., Price, D. L., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80272-x · Cited by 1,341
Astrocytes are active players in cerebral innate immunity
Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304
Mutations of optineurin in amyotrophic lateral sclerosis
Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., Kinoshita, Y., Kamada, M., Nodera, H., Suzuki, H., et al. (2010) · Nature · doi:10.1038/nature08971 · Cited by 1,265
Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Johnson, J. O., Mandrioli, J., Benatar, M., Abramzon, Y., Van Deerlin, V. M., Trojanowski, J. Q., Gibbs, J. R., Brunetti, M., Gronka, S., Wuu, J., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.036 · Cited by 1,235
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220
Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis
Rothstein, J. D., Martin, L. J., & Kuncl, R. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262204 · Cited by 1,197
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillée, S., Rule, M., McMahon, A. P., Doucette, W. T., Siwek, D. F., Ferrante, R. J., et al. (2003) · Science · doi:10.1126/science.1086071 · Cited by 1,131
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,069
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
Howland, D., Liu, J., She, Y., Goad, B., Maragakis, N. J., Kim, B. B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032539299 · Cited by 890
Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells
Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880
Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain
Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C., & Kriz, J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5360-06.2007 · Cited by 874
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model
Kaspar, B. K., Lladó, J., Sherkat, N., Rothstein, J. D., & Gage, F. H. (2003) · Science · doi:10.1126/science.1086137 · Cited by 872
Prevalence and patterns of cognitive impairment in sporadic ALS
Ringholz, G. M., Appel, S. H., Bradshaw, M. R., Cooke, N., Mosnik, D. M., & Schulz, P. E. (2005) · Neurology · doi:10.1212/01.wnl.0000172911.39167.b6 · Cited by 843
NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815
Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model
Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T., & Eggan, K. (2007) · Nature Neuroscience · doi:10.1038/nn1885 · Cited by 799
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
Turner, M. R., Cagnin, A., Turkheimer, F. E., Miller, C. C. J., Shaw, C. E., Brooks, D. J., Leigh, P. N., & Banati, R. B. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.012 · Cited by 737
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
Beers, D. R., Henkel, J. S., Xiao, Q., Zhao, W., Wang, J., Yen, A. A., Siklos, L., McKercher, S. R., & Appel, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607423103 · Cited by 733
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
Li, M., Ona, V. O., Guégan, C., Chen, M., Jackson-Lewis, V. R., Andrews, L. J., Olszewski, A. J., Stieg, P. E., Lee, J.-P., Przedborski, S., et al. (2000) · Science · doi:10.1126/science.288.5464.335 · Cited by 717
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
Wegorzewska, I., Bell, S., Cairns, N. J., Miller, T. M., & Baloh, R. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908767106 · Cited by 706
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Meletis, K., Barnabé‐Heider, F., Carlén, M., Evergren, E., Tomilin, N. V., Shupliakov, O., & Frisén, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060182 · Cited by 685
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
Bosco, D. A., Morfini, G. A., Karabacak, M., Song, Y., Gros‐Louis, F., Pasinelli, P., Goolsby, H., Fontaine, B. A., Lemay, N., McKenna-Yasek, D. M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2660 · Cited by 685
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
Neumann, M., Kwong, L. K., Lee, E. B., Kremmer, E., Flatley, A., Xu, Y., Forman, M. S., Troost, D., Kretzschmar, H. A., Trojanowski, J. Q., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-008-0477-9 · Cited by 608
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
Azzouz, M., Ralph, G. S., Storkebaum, E., Walmsley, L. E., Mitrophanous, K. A., Kingsman, S. M., Carmeliet, P., & Mazarakis, N. D. (2004) · Nature · doi:10.1038/nature02544 · Cited by 588
Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
Henkel-Tigges, J., Engelhardt, J., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R., & Appel, S. H. (2003) · Annals of Neurology · doi:10.1002/ana.10805 · Cited by 576
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.
Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
Ralph, G. S., Radcliffe, P. A., Day, D. M., Carthy, J. M., Leroux, M. A., Lee, D. C. P., Wong, L., Bilsland, L. G., Greensmith, L., Kingsman, S. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1205 · Cited by 507
Design, power, and interpretation of studies in the standard murine model of ALS
Scott, S., Kranz, J. E., Cole, J., Lincecum, J. M., Thompson, K., Kelly, N., Bostrom, A., Theodoss, J., Al‐Nakhala, B. M., Vieira, F. G., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701856300 · Cited by 504
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
Storkebaum, E., Lambrechts, D., Dewerchin, M. A., Moreno-Murciano, P., Appelmans, S., Oh, H., Damme, P. V., Rutten, B. P. F., Man, W. Y., Mol, M. D., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1360 · Cited by 499
Self-citation
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
Bosch, L. V. D., Damme, P. V., Bogaert, E., & Robberecht, W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.05.002 · Cited by 491
Self-citation
CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
Beers, D. R., Henkel-Tigges, J., Zhao, W., Wang, J., & Appel, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807419105 · Cited by 485
Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment
Pramatarova, A., Laganière, J., Roussel, J., Brisebois, K., & Rouleau, G. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03369.2001 · Cited by 482
Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis
Vargas, M. R., Johnson, D. A., Sirkis, D. W., Messing, A., & Johnson, J. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-08.2008 · Cited by 479
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlén, M., Meletis, K., Göritz, C., Darsalia, V., Evergren, E., Tanigaki, K., Amendola, M., Barnabé‐Heider, F., Yeung, M. S. Y., Naldini, L., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2268 · Cited by 463
Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease
Lepore, A. C., Rauck, B., Dejea, C., Pardo, A. C., Rao, M. S., Rothstein, J. D., & Maragakis, N. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2210 · Cited by 441
Immune reactivity in a mouse model of familial ALS correlates with disease progression
Alexianu, M. E., Kozovska, M., & Appel, S. H. (2001) · Neurology · doi:10.1212/wnl.57.7.1282 · Cited by 438
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
Raoul, C., Estévez, Á. G., Nishimune, H., Cleveland, D. W., deLapeyrière, O., Henderson, C. E., Haase, G., & Pettmann, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00905-4 · Cited by 432
Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease
Lino, M. M., Schneider, C., & Caroni, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04825.2002 · Cited by 424
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Damme, P. V., Hoecke, A. V., Lambrechts, D., Vanacker, P., Bogaert, E., Swieten, J. C. V., Carmeliet, P., Bosch, L. V. D., & Robberecht, W. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712039 · Cited by 421
Self-citation
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
Urushitani, M., Sik, A., Sakurai, T., Nukina, N., Takahashi, R., & Julien, J.-P. (2006) · Nature Neuroscience · doi:10.1038/nn1603 · Cited by 419
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.003 · Cited by 411
Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
Križ, J., Nguyen, M. D., & Julien, J. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0487 · Cited by 411
Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration
Gong, Y. H., Parsadanian, A. S., Andreeva, A., Snider, W. D., & Elliott, J. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00660.2000 · Cited by 387
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
Chiu, I. M., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S. A., Vartanian, T. K., Brown, R. H., & Carroll, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804610105 · Cited by 380
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
Harraz, M. M., Marden, J. J., Zhou, W., Zhang, Y., Williams, A. J., Sharov, V. S., Nelson, K., Luo, M., Paulson, H. L., Schöneich, C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34060 · Cited by 375
Microglia in ALS: The Good, The Bad, and The Resting
Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 332
Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease
Nagai, M., Aoki, M., Miyoshi, I., Kato, M., Pasinelli, P., Kasai, N., Brown, R. H., & Itoyama, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09246.2001 · Cited by 318
Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis
Engelhardt, J. I., Tajti, J., & Appel, S. H. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540010026013 · Cited by 318
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
Yamanaka, K., Boillee, S., Roberts, E. A., Garcia, M. L., McAlonis-Downes, M., Mikse, O. R., Cleveland, D. W., & Goldstein, L. S. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802556105 · Cited by 309
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
Drachman, D. B., Frank, K., Dykes‐Hoberg, M., Teismann, P., Almer, G., Przedborski, S., & Rothstein, J. D. (2002) · Annals of Neurology · doi:10.1002/ana.10374 · Cited by 307
Trial of celecoxib in amyotrophic lateral sclerosis
Cudkowicz, M., Shefner, J. M., Schoenfeld, D., Zhang, H., Andreasson, K. I., Rothstein, J. D., & Drachman, D. B. (2006) · Annals of Neurology · doi:10.1002/ana.20903 · Cited by 302
Minocycline delays disease onset and mortality in a transgenic model of ALS
Bosch, L. V. D., Tilkin, P., Lemmens, G., & Robberecht, W. (2002) · Neuroreport · doi:10.1097/00001756-200206120-00018 · Cited by 297
Self-citation
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
Guo, H. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg267 · Cited by 297
A clinical trial of creatine in ALS
Shefner, J. M., Cudkowicz, M., Schoenfeld, D., Conrad, T. M., Taft, J., Chilton, M., Urbinelli, L., Qureshi, M., Zhang, H., Pestronk, A., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000142992.81995.f0 · Cited by 293
Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury
Zhao, W., Beers, D. R., Henkel, J. S., Zhang, W., Urushitani, M., Julien, J., & Appel, S. H. (2010) · Glia · doi:10.1002/glia.20919 · Cited by 288
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase‐1 transgenic mice: Mechanisms of mitochondriopathy and cell death
Martin, L. J., Liu, Z., Chen, K. Y., Price, A. C., Pan, Y. H., Swaby, J. A., & Golden, W. C. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21160 · Cited by 270
Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice
Jaarsma, D., Teuling, E., Haasdijk, E. D., Zeeuw, C. I. D., & Hoogenraad, C. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5258-07.2008 · Cited by 260
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
Wu, D., Ré, D. B., Nagai, M., Ischiropoulos, H., & Przedborski, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603670103 · Cited by 258
T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
Appel, S. H., Beers, D. R., & Henkel, J. S. (2010) · Trends in Immunology · doi:10.1016/j.it.2009.09.003 · Cited by 256
Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis
Schiffer, D., Cordera, S., Cavalla, P., & Migheli, A. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00073-1 · Cited by 255
Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1
Yang, Y., Gozen, O., Watkins, A., Lorenzini, I., Lepore, A., Gao, Y., Vidensky, S., Brennan, J., Poulsen, D., Won Park, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.010 · Cited by 237
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
Damme, P. V., Bogaert, E., Dewil, M., Hersmus, N., Kiraly, D., Scheveneels, W., Bockx, I., Braeken, D., Verpoorten, N., Verhoeven, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705046104 · Cited by 236
Self-citation
Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III
Kaufmann, P., Thompson, J. L. P., Levy, G., Buchsbaum, R., Shefner, J. M., Krivickas, L. S., Katz, J., Rollins, Y. D., Barohn, R. J., Jackson, C. E., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21743 · Cited by 236
IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis
Engelhardt, J. I., & Appel, S. H. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110068019 · Cited by 221
Powerful beneficial effects of macrophage colony-stimulating factor on -amyloid deposition and cognitive impairment in Alzheimer's disease
Boissonneault, V., Filali, M., Lessard, M., Relton, J., Wong, G., & Rivest, S. (2008) · Brain · doi:10.1093/brain/awn331 · Cited by 221
Transgenic-Mouse Model of Amyotrophic Lateral Sclerosis
Gurney, M. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412223312516 · Cited by 217
Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice
Wang, L., Gutmann, D. H., & Roos, R. P. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq463 · Cited by 214
Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene
Zhou, H., Huang, C., Chen, H., Wang, D., Landel, C. P., Xia, P. Y., Bowser, R. P., Liu, Y.-J., & Xia, X. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000887 · Cited by 209
Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis
Hensley, K., Floyd, R. A., Gordon, B., Mou, S., Pye, Q. N., Stewart, C. A., West, M. S., & Williamson, K. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00968.x · Cited by 205
Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
Banerjee, R., Mosley, R. L., Reynolds, A. D., Dhar, A., Jackson-Lewis, V. R., Gordon, P. H., Przedborski, S., & Gendelman, H. E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002740 · Cited by 204
Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis
Poloni, M., Facchetti, D., Mai, R., Micheli, A., Agnoletti, L., Francolini, G., Mora, G., Camana, C., Mazzini, L., & Bachetti, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01177-0 · Cited by 197
Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues
Corti, S. P., Locatelli, F., Donadoni, C., Guglieri, M., Papadimitriou, D. A., Strazzer, S., Bo, R. D., & Comi, G. P. (2004) · Brain · doi:10.1093/brain/awh273 · Cited by 195
Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
Chiu, I. M., Phatnani, H. P., Kuligowski, M., Tapia, J. C., Carrasco, M. A., Zhang, M., Maniatis, T., & Carroll, M. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911405106 · Cited by 194
Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Kiaei, M., Petri, S., Kipiani, K., Gardian, G., Choi, D., Chen, J., Calingasan, N. Y., Schafer, P. H., Muller, G. W., Stewart, C. A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5253-05.2006 · Cited by 183
The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
Henkel-Tigges, J., Beers, D. R., Siklós, L., & Appel, S. H. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.016 · Cited by 181
Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis
Elliott, J. L. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00242-x · Cited by 181
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
Zhong, Z., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38476 · Cited by 176
Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia
Xiao, Q., Zhao, W., Beers, D. R., Yen, A. A., Xie, W., Henkel, J. S., & Appel, S. H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04677.x · Cited by 174
NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord.
Zhu, X., Hill, R., & Nishiyama, A. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09000015 · Cited by 168
Reactive Astrogliosis is Widespread in the Subcortical White Matter of Amyotrophic Lateral Sclerosis Brain
Kushner, P. D., Stephenson, D. T., & Wright, S. (1991) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199105000-00008 · Cited by 166
Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity
Dodge, J. C., Haidet, A. M., Yang, W., Passini, M. A., Hester, M. E., Clarke, J., Roskelley, E. M., Treleaven, C. M., Rizo, L., Martin, H. L., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.60 · Cited by 160
Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase
Gowing, G., Philips, T., Wijmeersch, B. V., Audet, J., Dewil, M., Bosch, L. V. D., Billiau, A., Robberecht, W., & Julien, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3494-08.2008 · Cited by 159
Self-citation
Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
Zhang, R., Gascon, R., Miller, R. G., Gelinas, D. F., Mass, J., Hadlock, K. G., Jin, X., Reis, J., Narvaez, A., & McGrath, M. S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.009 · Cited by 158
Increased cytotoxic potential of microglia from ALS‐transgenic mice
Weydt, P., Yuen, E., Ransom, B. R., & Möller, T. (2004) · Glia · doi:10.1002/glia.20062 · Cited by 147
Redox modifier genes in amyotrophic lateral sclerosis in mice
Marden, J. J., Harraz, M. M., Williams, A. J., Nelson, K., Luo, M., Paulson, H., & Engelhardt, J. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31265 · Cited by 145
A therapeutic role for cyclooxygenase‐2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
Pompl, P. N., Ho, L., Bianchi, M., McManus, T. E., Qin, W., & Pasinetti, G. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-0876fje · Cited by 144
Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
Appel, S. H., Engelhardt, J. I., Henkel-Tigges, J., Siklós, L., Beers, D. R., Yen, A. A., Simpson, E. P., Luo, Y., Carrum, G., Heslop, H., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000327668.43541.22 · Cited by 140
Motor Neuron Degeneration Promotes Neural Progenitor Cell Proliferation, Migration, and Neurogenesis in the Spinal Cords of Amyotrophic Lateral Sclerosis Mice
Chi, L.-Y., Ke, Y., Luo, C., Li, B.-L., Gozal, D., Kalyanaraman, B., & Liu, R.-G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0076 · Cited by 134
Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis
Nagy, D., Kato, T., & Kushner, P. D. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380312 · Cited by 131
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: No requirement for proapoptotic interleukin‐1β in neurodegeneration
Nguyen, M. D., Julien, J., & Rivest, S. (2001) · Annals of Neurology · doi:10.1002/ana.1256 · Cited by 129
The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice
West, M. S., Mhatre, M., Ceballos, A., Floyd, R. A., Grammas, P., Gabbita, S. P., Hamdheydari, L., Mai, T., Mou, S., Pye, Q. N., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02700.x · Cited by 121
The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis
Wang, L., Sharma, K., Grisotti, G., & Roos, R. P. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.002 · Cited by 121
Frontotemporal Lobar Degeneration
(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-44781-2.50191-1 · Cited by 120
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
Wilkinson, B. L., Cramer, P. E., Varvel, N. H., Reed-Geaghan, E. G., Jiang, Q., Szabo, A., Herrup, K., Lamb, B. T., & Landreth, G. E. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.014 · Cited by 118
Visualization of mitotic radial glial lineage cells in the developing rat brain by Cdc2 kinase-phosphorylated vimentin
Kamei, Y., Inagaki, N., Nishizawa, M., Tsutsumi, O., Taketani, Y., & Inagaki, M. (1998) · Glia · doi:10.1002/(sici)1098-1136(199807)23:3 · Cited by 114
Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
Solomon, J. N., Lewis, C. B., Ajami, B., Corbel, S. Y., Rossi, F. M. V., & Krieger, C. (2006) · Glia · doi:10.1002/glia.20331 · Cited by 105
Absence of Tumor Necrosis Factor-α Does Not Affect Motor Neuron Disease Caused by Superoxide Dismutase 1 Mutations
Gowing, G., Dequen, F., Soucy, G., & Julien, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0602-06.2006 · Cited by 105
Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology
Wang, L., Sharma, K., Deng, H., Siddique, T., Grisotti, G., Liu, E., & Roos, R. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.10.004 · Cited by 101
Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial
Meininger, V., Drory, V. E., Leigh, P. N., Ludolph, A. C., Robberecht, W., & Silani, V. (2009) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960902803432 · Cited by 97
Self-citation
Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
Lepore, A. C., Dejea, C. M., Carmen, J., Rauck, B. M., Kerr, D. A., Sofroniew, M. V., & Maragakis, N. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.02.020 · Cited by 92
Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice
Park, S., Kim, H.-T., Yun, S., Kim, I., Lee, J., Lee, I.-S., & Park, K. I. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.7.054 · Cited by 90
Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration
Philips, T., Muynck, L. D., Thu, H. N. T., Weynants, B., Vanacker, P., Dhondt, J., Sleegers, K., Schelhaas, H. J., Verbeek, M. M., Vandenberghe, R. R., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181fc9aea · Cited by 83
Self-citation
Lenalidomide (Revlimid®) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis
Neymotin, A., Petri, S., Calingasan, N. Y., Wille, E. J., Schafer, P. H., Stewart, C. A., Hensley, K., Beal, M. F., & Kiaei, M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.028 · Cited by 80
Recent advances in motor neuron disease
Damme, P. V., & Robberecht, W. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832ffbe3 · Cited by 76
Self-citation
Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis
Gros‐Louis, F., Andersen, P. M., Dupré, N., Urushitani, M., Dion, P. A., Souchon, F., D'Amour, M. L., Camu, W., Meininger, V., Bouchard, J.-P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902174106 · Cited by 58
Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase
Gowing, G., Lalancette-Hébert, M., Audet, J.-N., Dequen, F., & Julien, J.-P. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.021 · Cited by 53
Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
Ohnishi, S., Ito, H., Suzuki, Y., Adachi, Y., Wate, R., Zhang, J., Nakano, S., Kusaka, H., & Ikehara, S. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.012 · Cited by 50
Inducible Nitric Oxide Synthase (iNOS) and Nitrotyrosine Immunoreactivity in the Spinal Cords of Transgenic Mice with a G93A MutantSOD1Gene
Sasaki, S., Warita, H., Abe, K., & Iwata, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.839 · Cited by 46
Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study
Galbussera, A. A., Tremolizzo, L., Brighina, L., Testa, D., Lovati, R., Ferrarese, C., Cavaletti, G., & Filippini, G. (2006) · Neurological Sciences · doi:10.1007/s10072-006-0668-x · Cited by 44
Leech giant glial cell: functional role in a simple nervous system
Deitmer, J. W., Rose, C. R., Munsch, T., Schmidt, J., Nett, W., Schneider, H.-P., & Lohr, C. (1999) · Glia · doi:10.1002/(sici)1098-1136(199912)28:3 · Cited by 43
Bone marrow‐derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX3CR1
Lewis, C. B., Solomon, J. N., Rossi, F. M. V., & Krieger, C. (2009) · Glia · doi:10.1002/glia.20859 · Cited by 40
Neuronal over‐expression of chromogranin A accelerates disease onset in a mouse model of ALS
Ezzi, S. A., Larivière, R., Urushitani, M., & Julien, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06979.x · Cited by 34
Survival in a transgenic model of fals is independent of inos expression
Son, M., Fathallah‐Shaykh, H. M., & Elliott, J. L. (2001) · Annals of Neurology · doi:10.1002/ana.1104 · Cited by 30
Altered immune response to CNS viral infection in mice with a conditional knock‐down of macrophage‐lineage cells
Carmen, J., Gowing, G., Julien, J., & Kerr, D. A. (2006) · Glia · doi:10.1002/glia.20359 · Cited by 15
P413L CHGB is not associated with ALS susceptibility or age at onset in a Dutch population
van Vught, P. W. J., Veldink, J. H., & van den Berg, L. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002512107 · Cited by 13
Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.
van Geel (2001) · Open Repository and Bibliography (University of Luxembourg) · doi:10.1002/1531-8249(20010201)49:2 · Cited by 7

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Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190
Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
The changing scene of amyotrophic lateral sclerosis
Robberecht, W., & Philips, T. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3430 · Cited by 957
Self-citation
Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity
Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease
Lian, H., Litvinchuk, A., Chiang, A. C.-A., Aithmitti, N., Jankowsky, J. L., & Zheng, H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2117-15.2016 · Cited by 597
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Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 609
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Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 477
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Ben Haim, L., Carrillo-de Sauvage, M.-A., CeyzÃ©riat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453
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Matta, S. M., Hill‐Yardin, E. L., & Crack, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.037 · Cited by 431
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Beers, D. R., & Appel, S. H. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30394-6 · Cited by 396
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Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1039-8 · Cited by 354
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Grad, L. I., Rouleau, G. A., Ravits, J., & Cashman, N. R. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a024117 · Cited by 344
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Self-citation
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Self-citation
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Self-citation
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Zufiría, M., Gil-Bea, F. J., Fernández‐Torrón, R., Poza, J. J., Muñoz-Blanco, J. L., Rojas‐García, R., Riancho, J., & de Munaín, A. L. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.05.004 · Cited by 203
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189
Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy
Zhang, Z., Pinto, A. M., Wan, L., Wang, W., Berg, M. G., Oliva, I. B., Singh, L. N., Dengler, C. G., Wei, Z., & Dreyfuss, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319280110 · Cited by 193
Inflammation and neurovascular changes in amyotrophic lateral sclerosis
Evans, M. C., Couch, Y., Sibson, N. R., & Turner, M. R. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.10.008 · Cited by 174
Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Zhao, W., Beers, D. R., Hooten, K. G., Sieglaff, D. H., Zhang, A., Sundaram, S. K., Traini, C., Halsey, W. S., Hughes, A. M., Sathe, G. M., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0357 · Cited by 176
Mechanisms, models and biomarkers in amyotrophic lateral sclerosis
Turner, M. R., Bowser, R. P., Bruijn, L. I., Dupuis, L., Ludolph, A. C., McGrath, M. S., Manfredi, G., Maragakis, N. J., Miller, R. G., Pullman, S. L., et al. (2013) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2013.778554 · Cited by 168
Molecular diagnostics of neurodegenerative disorders
Agrawal, M., & Biswas, A. (2015) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2015.00054 · Cited by 164
Overturning the Paradigm of Spinal Muscular Atrophy as Just a Motor Neuron Disease
Yeo, C. J. J., & Darras, B. T. (2020) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2020.01.003 · Cited by 171
The fecal microbiome of ALS patients
Brenner, D., Hiergeist, A., Adis, C. I., Mayer, B., Gessner, A., Ludolph, A. C., & Weishaupt, J. H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.023 · Cited by 155
Rodent models of amyotrophic lateral sclerosis
McGoldrick, P., Joyce, P. I., Fisher, E., & Greensmith, L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.012 · Cited by 162
Microglial activation in the pathogenesis of Huntington's disease
Yang, H.-M., Yang, S., Huang, S.-S., Tang, B.-S., & Guo, J.-F. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00193 · Cited by 151
Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics
Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152
A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis
Dupuis, L., Dengler, R., Heneka, M. T., Meyer, T., Zierz, S., Kassubek, J., Fischer, W., Steiner, F., Lindauer, E., Otto, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037885 · Cited by 159
Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response
Bendotti, C., Marino, M., Cheroni, C., Fontana, E., Crippa, V., Poletti, A., & Biasi, S. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.10.001 · Cited by 159
Therapeutic Potential of Targeting the Ghrelin Pathway
Colldén, G., Tschöp, M. H., & Müller, T. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040798 · Cited by 158
Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
Staff, N. P., Jones, D. T., & Singer, W. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.001 · Cited by 150
Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
Vahsen, B. F., Gray, E., Thompson, A. G., Ansorge, O., Anthony, D. C., Cowley, S. A., Talbot, K., & Turner, M. R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00487-8 · Cited by 147
Neuroimaging in Amyotrophic Lateral Sclerosis
Turner, M. R., Agosta, F., Bede, P., Govind, V., Lulé, D. E., & Verstraete, E. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.26 · Cited by 152
Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis?
Turner, M. R., & Kiernan, M. C. (2012) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482968.2011.636050 · Cited by 144
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Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 155
Oxidative and Nitrosative Stress and Immune-inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
Morris, G., & Maes, M. H. J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120224653 · Cited by 142
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Guerrero, E. N., Wang, H., Mitra, J., Hegde, P. M., Stowell, S. E., Liachko, N. F., Kraemer, B. C., Garruto, R. M., Rao, K. S. J., & Hegde, M. L. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.09.004 · Cited by 146
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The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey
Turner, M. R., & Swash, M. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-308946 · Cited by 127
Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression
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Apolloni, S., Parisi, C., Pesaresi, M. G., Rossi, S., Carrı̀, M. T., Cozzolino, M., Volonté, C., & D’Ambrosi, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203262 · Cited by 132
Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation
Giunti, D., Marini, C., Parodi, B., Usai, C., Milanese, M., Bonanno, G., de Rosbo, N. K., & Uccelli, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-81039-4 · Cited by 129
Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation
Kasatkina, L. A., Rittchen, S., & Sturm, E. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115431 · Cited by 133
Role of Pyroptosis in Traumatic Brain and Spinal Cord Injuries
Hu, X., Chen, H. A., Xu, H., Wu, Y., Wu, C., Jia, C., Li, Y., Sheng, S., Xu, C., Xu, H., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45467 · Cited by 126
Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses
Béland, L.-C., Markovinovic, A., Jakovac, H., De Marchi, F., Bilic, E., Mazzini, L., Kriz, J., & Munitic, I. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa124 · Cited by 125
The human gut microbiota in people with amyotrophic lateral sclerosis
Nicholson, K., Bjornevik, K., Abu-Ali, G., Chan, J., Cortese, M., Dedi, B., Jeon, M., Xavier, R., Huttenhower, C., Ascherio, A., et al. (2021) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1828475 · Cited by 123
Regulated cell death: discovery, features and implications for neurodegenerative diseases
Cui, J., Zhao, S., Li, Y., Zhang, D., Wang, B., Xie, J., & Wang, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00799-8 · Cited by 130
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis
Tönges, L., Günther, R., Suhr, M., Jansen, J., Balck, A., Saal, K., Barski, E., Nientied, T., Götz, A. A., Koch, J., et al. (2014) · Glia · doi:10.1002/glia.22601 · Cited by 121
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Spinal cord pathology is ameliorated by P2X7 antagonism in SOD1-G93A mouse model of amyotrophic lateral sclerosis
Apolloni, S., Amadio, S., Parisi, C., Matteucci, A., Potenza, R. L., Armida, M., Popoli, P., D’Ambrosi, N., & Volonté, C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.017038 · Cited by 119
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Marchi, E. D., Orioli, E., Ben, D. D., & Adinolfi, E. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2015.11.004 · Cited by 117
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Apolloni, S., Amadio, S., Montilli, C., Volonte, C., & D'Ambrosi, N. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt259 · Cited by 109
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Medinas, D., Rozas, P., Traub, F. M., Woehlbier, U., Brown, R. H., Bosco, D. A., & Hetz, C. (2018) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1801109115 · Cited by 87
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Biomarkers in amyotrophic lateral sclerosis: opportunities and limitations
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Saba, L., Viscomi, M. T., Caioli, S., Pignataro, A., Bisicchia, E., Pieri, M., Molinari, M., Ammassari‐Teule, M., & Zona, C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu317 · Cited by 110
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Moser, J., Bigini, P., & Schmitt‐John, T. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0741-0 · Cited by 108
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Authors: Philips, T., & Robberecht, W.
Affiliations: KU Leuven (BE)
Corresponding author: Robberecht, Wim
ORCID: Philips, Thomas
Venue: The Lancet Neurology
Publisher: Elsevier BV
Published: 2011-03
Volume: 10
Issue: 3
Pages: 253-263
ISSN: 1474-4422 (ISSN-L)
DOI: 10.1016/s1474-4422(11)70015-1
OpenAlex: W2144507462
Cited by: 646
References: 133
Citations by year: 2026: 25 · 2025: 24 · 2024: 39 · 2023: 45 · 2022: 38 · 2021: 44 · 2020: 45 · 2019: 41 · 2018: 43 · 2017: 58 · 2016: 44 · 2015: 41 · 2014: 52 · 2013: 53 · 2012: 40
FWCI: 6.36
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Neurology (publishedVersion)
PubMed (publishedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: amyotrophic lateral sclerosis, neuroinflammation, glial activation, microglia, astrocytes, motor neuron degeneration, neurodegeneration
MeSH terms: Amyotrophic Lateral Sclerosis, Animals, Humans, Inflammation, Neuroglia, T-Lymphocytes, Signal Transduction, Motor Neuron Disease

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Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

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