The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain
Abstract
Steroid hormones play an influential role in neural development. In addition to androgens and estrogens of fetal and neonatal origin, the developing brain may also be exposed to progesterone. In this regard, identifying forebrain nuclei that are sensitive to progesterone during neural development may elucidate the impact of progesterone on the developing brain. Using immunocytochemistry, the present study documented the distribution of progesterone receptor (PR) expression in the rat forebrain from embryonic day (E) 17 through postnatal day (P) 28. The results indicate that PR expression in the developing brain is extensive, present in numerous forebrain nuclei, but transient, in that PR expression was absent in most nuclei by P28. Regions displaying the highest levels of PR‐immunoreactivity (PRir) were found in preoptic and hypothalamic nuclei including the medial preoptic, anteroventral periventricular, arcuate, and ventromedial nuclei. PRir was moderately abundant in the limbic region, particularly in subdivisions of the amygdala, the bed nucleus of the stria terminalis, and hippocampus. The choroid plexus and neocortex were additional structures that demonstrated relatively abundant levels of PRir. The presence PR expression in the developing forebrain implicates the involvement of progesterone and PR in fundamental mechanisms of neural development. J. Comp. Neurol. 504:42–56, 2007. © 2007 Wiley‐Liss, Inc.
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“Males express PRs as early as embryonic day 20 in many brain areas [7]”
From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [7]
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- Quadros PS, 1999, Fetal progesterone is of maternal origin, Soc Neurosci Abstr, 25, 228
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Dang, J., & Beyer, C. (2012) · RWTH Publications (RWTH Aachen)
(2021) · Elsevier eBooks · doi:10.1016/b978-0-323-68013-4.00080-8
Sex-specific effects of neonatal progestin receptor antagonism on juvenile social behavior in rats.Preprint
Forbes‐Lorman, R. M. (2021) · Research Square · doi:10.21203/rs.3.rs-649875/v1
Effect of estrogen on manganese-induced toxicity on embryonic astrocytes
Huynh, T. T., Baker, K. J., & Komiskey, H. L. (2013) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2013.410a1002
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Gonzales, K. L. (2010) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/kgr7-heec
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Neuroendocrine disruption of reproduction
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Lateral hypothalamic area: A central node for maternal behavior modulation
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Metadata
- Authors
- Quadros, P. S., Pfau, J. L., & Wagner, C. K.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Wagner, Christine K.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2007-07-05
- Volume
- 504
- Issue
- 1
- Pages
- 42-56
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2028117758
- Cited by
- 112
- References
- 81
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 13 · 2015: 7 · 2014: 1 · 2013: 8 · 2012: 9
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National d’Etudes Spatiales
- National Institutes of Health (5r01hd037244-05)
- National Institute of Mental Health (MH-65874, F31MH065874)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37244)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- progesterone receptor, progesterone, forebrain development, fetal brain, neonatal brain, rats, hypothalamic nuclei, amygdala, bed nucleus of the stria terminalis, hippocampus, choroid plexus, neocortex, steroid hormones, neural development
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Female, Immunohistochemistry, Pregnancy, Receptors, Progesterone, Tissue Distribution, Prosencephalon, Rats, Sprague-Dawley, Organogenesis, Rats
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